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Traditional Chinese medicine bone peptide composition with function of improving bone joint health and preparation method of traditional Chinese medicine bone peptide composition

A composition, bone and joint technology, applied in drug combinations, medical preparations containing active ingredients, pharmaceutical formulas, etc., can solve problems such as harmful effects, drug dependence effects, and unclear curative effects

Active Publication Date: 2021-05-18
NINGBO YUFANGTANG BIOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, "medicine is three-point poisonous", excessive intake of western medicine has a series of side effects, which will increase the burden of liver and kidney metabolism, produce serious gastrointestinal adverse reactions, and also produce drug dependence effects, which have a great impact on our health. The hidden dangers of safety also limit its applicable population to a certain extent; joint replacement is a large-scale operation, which is expensive and irreversible; restorative treatment treats the symptoms but not the root cause, and is prone to recurrence; the curative effects of basic treatment, physical therapy, and exercise support are not clear. And improper operation can have harmful effects

Method used

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  • Traditional Chinese medicine bone peptide composition with function of improving bone joint health and preparation method of traditional Chinese medicine bone peptide composition
  • Traditional Chinese medicine bone peptide composition with function of improving bone joint health and preparation method of traditional Chinese medicine bone peptide composition
  • Traditional Chinese medicine bone peptide composition with function of improving bone joint health and preparation method of traditional Chinese medicine bone peptide composition

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0075] (1) The required marine fish bone collagen oligopeptide is obtained by pulverizing the marine fish bone, enzymatic hydrolysis, centrifugal filtration, concentration under reduced pressure and spray drying. The specific process is as follows:

[0076] (a) Grinding and mixing: crush the marine fish bone and pass through an 80-mesh sieve, add 12 times of pure water, mix the marine fish bone meal evenly, and disperse it in the aqueous solution to prepare a marine fish bone meal dispersion liquid to adjust the dispersion of the marine fish bone meal Solution pH to 8.0;

[0077] (b) Enzymolysis: heat and keep the temperature at 37°C, add trypsin and neutral protease into the marine fish bone powder dispersion, stir evenly for 1.5 hours, raise the temperature to 56°C, continue to stir for 2 hours, and trypsin The added amount of protease is 0.3wt% of the substrate content, and the added amount of neutral protease is 0.4wt% of the substrate content. After the enzymolysis is com...

Embodiment 2

[0102] (1) Crush marine fish bones and pass through a 100-mesh sieve, add pure water 20 times the weight of the material to prepare a dispersion, adjust the pH to 8.5, heat and keep at 37°C, add trypsin and neutral protease, and stir for 2.5 hours to enzymatically hydrolyze. Heat up to 52°C, continue enzymolysis for 2 hours to obtain an enzymolysis liquid, the amount of trypsin added is 0.35wt% of the substrate amount, the amount of neutral protease added is 0.25wt% of the substrate amount, and the enzyme is deactivated after the enzymolysis; enzymolysis The liquid was centrifuged at 12000rpm, the clear liquid was collected, and filtered through a microporous membrane with a thickness of 60μm, a pore size of 3μm, and a pressure of 0.1MPa to remove the filter residue; the filtrate was desalted and decolorized by ion exchange columns and activated carbon columns, and free Amino acids; the filtrate is concentrated under reduced pressure at a concentration temperature of 65°C and a...

Embodiment 3

[0107] (1) Crush marine fish bones and pass through a 60-mesh sieve, add pure water 10 times the weight of the material to prepare a dispersion, adjust the pH to 6.5, heat and keep it at 38°C, add trypsin and neutral protease, and stir for 1.5 hours to enzymatically hydrolyze. Heat up to 58°C, continue enzymolysis for 2.5 hours to obtain enzymolysis solution, the amount of trypsin added is 0.35wt% of the substrate amount, the amount of neutral protease added is 0.3wt% of the substrate amount, and the enzyme is extinguished after the end of the enzymolysis; The solution was centrifuged at 14000rpm, the clear liquid was collected, and filtered through a microporous membrane with a thickness of 90μm, a pore size of 5μm, and a pressure of 0.1MPa to remove the filter residue; the filtrate was desalted and decolorized by an ion exchange column and an activated carbon column, and removed Free amino acids; the filtrate was concentrated under reduced pressure at a concentration temperat...

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Abstract

The invention discloses a traditional Chinese medicine bone peptide composition with a function of improving bone joint health. The traditional Chinese medicine bone peptide composition comprises the following components in parts by mass of 26-42 parts of marine fishbone collagen oligopeptide, 4-11 parts of alfalfa extract, 2.5-7.5 parts of plantago depressa extract, 3-8 parts of acacia farnesiana extract, 2-5 parts of basella alba extract, 3-7 parts of rabdosia rubescens extract, 3-7 parts of patrinia extract, 0.5-1.5 parts of sodium hyaluronate, 3-7 parts of salmon nasal cartilage extract, 8-16 parts of shark cartilage extract, 2-5 parts of curcumin and 8-18 parts of chitosan oligosaccharide. The invention further discloses a preparation method of the traditional Chinese medicine bone peptide composition. Compared with the prior art, the traditional Chinese medicine bone peptide composition not only achieves the effect of improving bone joint health, but also does not damage visceral organs, mildly diminishes inflammation and relieves pain, repairs cartilage and other bone tissues, promotes synovial fluid secretion, reduces swelling and expels pus, and reduces or avoids adverse reactions and side effects to the maximum extent.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicine compositions, in particular to a traditional Chinese medicine osteopeptide composition capable of improving bone and joint health and a preparation method thereof. Background technique [0002] Osteoarthritis occurs when the joints of the human body age to a certain extent. Osteoarthritis refers to the degenerative changes in the articular cartilage of the human body, so that the articular cartilage of the human body is destroyed and lost, and it is accompanied by bone hyperplasia around the joints. Reacting to the disease not only brings pain to the patient, but also brings heavy financial, human and material burdens to the patient's family. The protective layer of bone joints is articular cartilage. Its degeneration and wear are the main causes of osteoarthritis. Hypertrophic bony spurs, or hyperosteogeny, are osteophytes formed at the attachments of diseased joints and liga...

Claims

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Application Information

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IPC IPC(8): A61K38/01A61P19/02A61P29/00A61P19/08A61K31/12A61K31/702A61K31/722A61K31/728A61K35/60
CPCA61K38/014A61K36/48A61K36/68A61K36/185A61K36/53A61K36/84A61K35/60A61K31/12A61K31/728A61K31/722A61K31/702A61P19/02A61P29/00A61P19/08A61K2236/37A61K2300/00Y02P20/54
Inventor 陶刚熊菲菲王俊涂宏建雷蕾王彩霞袁媛宴永球贾福怀
Owner NINGBO YUFANGTANG BIOTECH
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