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Preparation method of sulfaquinoxaline electrochemical aptamer sensor based on internal circulation amplification strategy

A sulfaquinoxaline and aptamer sensor technology, which is applied to scientific instruments, instruments, and material analysis through electromagnetic means, to achieve the effects of good repeatability, high accuracy, and high sensitivity

Active Publication Date: 2021-04-30
HENAN UNIVERSITY OF TECHNOLOGY
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Problems solved by technology

At present, the design and synthesis of aminated biconical metal materials@bimetallic / ultrathin ribbon nanomaterials, and the above-mentioned composite nanomaterials as signal amplification materials to construct electrochemical aptasensors with internal loop amplification strategies for sulfaquinoxaline detection has not yet been reported

Method used

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Embodiment 1

[0029] Specific steps are as follows:

[0030] (1) Preparation of aminated biconical cobalt metal material@platinum-palladium bimetallic material: firstly, the aminated biconical cobalt metal material was synthesized by hydrothermal synthesis, and 60 mg of cobalt dichloride hexahydrate and 31 mg of dichloride dichloride were weighed. Aminoterephthalic acid was added to 10 mL of dimethylformamide, transferred to an autoclave at room temperature, then 28 μL of water was added, sealed and placed in an oven, heated at a constant temperature of 120 °C for 20 h, left for 3 h, at 8000 rpm Centrifuge at a rotating speed for 6 min, wash with water and ethanol, and dry at 75 °C for 10 h to obtain the aminated biconical cobalt metal material; then use the surface growth method to grow bimetal on the surface of the aminated biconical cobalt metal material, and add 0.5 mL of H 2 PtCl 6 solution (1%) and 0.5 mL of Na 2 PdCl 4 solution (1%) was added to 2 mL of aminated biconical cobalt m...

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Abstract

The invention relates to a sulfaquinoxaline electrochemical aptamer sensor preparation method based on an internal circulation amplification strategy, which comprises the following steps: preparing a bimetal-coated aminated biconical metal material by using a hydrothermal method, and growing bimetal nanoparticles on the surface of the metal material by using a reducing agent to prepare an aminated biconical metal material@bimetal nano material, synthesizing an ultrathin strip-shaped nano material through a hydrothermal method, modifying the nano material to the surface of a gold electrode through a gold ammonia bond to obtain an aminated biconical metal material@bimetal / ultrathin strip-shaped nano material / gold electrode, and forming a DNA double-chain structure in vitro, indicating the content of sulfaquinoxaline in a sample through the response change of signal molecules, and obtaining the electrochemical aptamer sensor based on the internal circulation amplification strategy for sulfaquinoxaline detection. Compared with other electrochemical sensors for detecting the content of sulfaquinoxaline, the prepared electrochemical aptamer sensor based on the internal circulation amplification strategy has the advantages of being high in sensitivity, good in repeatability and high in accuracy.

Description

technical field [0001] The invention relates to a method for preparing a sulfaquinoxaline electrochemical aptamer sensor based on an internal circulation amplification strategy, in particular to a method for preparing an aminated biconical metal material@bimetal / ultra-thin ribbon nanomaterial / gold electrode. Background technique [0002] Nowadays, people's demand for material life has gradually increased from the basic needs of food and clothing to the scientific level of diet structure and diet quality. Animal food is rich in high-quality protein, and has already occupied a large proportion in human daily food. The vast consumer market has promoted the development of animal husbandry, and at the same time brought food safety hazards. Sulfaquinoxaline is a kind of artificially synthesized chemical antibacterial drug, which has a good curative effect on the bacterial diseases and coccidiosis of the digestive tract of livestock and poultry. It is also a growth promoter for po...

Claims

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Application Information

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IPC IPC(8): G01N27/327
CPCG01N27/3278
Inventor 何保山李淑莹梁赢王金水张付洞姜利英魏涛金华丽卫敏任文洁索志光
Owner HENAN UNIVERSITY OF TECHNOLOGY
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