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Lighting type fluorescent probe for formaldehyde detection

A fluorescent and formaldehyde-based technology, applied in the field of light-up fluorescent probes for formaldehyde detection, can solve the problems of insufficient sensitivity, expensive technology, and training for formaldehyde

Pending Publication Date: 2021-04-30
THE HONG KONG UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Several techniques for formaldehyde detection exist, such as high-performance liquid chromatography, spectrophotometry, and gas chromatography, but these methods require expensive machinery and specialized technical training
Other techniques, such as piezoelectric, potentiometric, and electrochemical techniques, are not sufficiently sensitive for formaldehyde detection

Method used

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  • Lighting type fluorescent probe for formaldehyde detection
  • Lighting type fluorescent probe for formaldehyde detection
  • Lighting type fluorescent probe for formaldehyde detection

Examples

Experimental program
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Embodiment 1

[0033] Embodiment 1 - gas phase fluorescence detection of amines:

[0034] In this application, we synthesized amino-modified 1,8-naphthalene anhydride derivatives ( figure 1 ), and use 1 H NMR and HRMS were characterized (Fig. 2). The compound 2-amino-6-hydrazino-1H-benzisoquinoline-1,3(2H)-dione (AHB) is non-emissive in solid or solution state due to photoinduced electron transfer ( The photo-induced electron transfer (PET) effect can suppress the radiative attenuation by transferring electrons from donor orbitals to acceptor orbitals. However, the reaction of AHB with formaldehyde is able to hinder the PET process, so upon exposure to FA, the AHB molecule is “turned on” and thus enhances the emission intensity ( image 3 ). The optical properties and absorption and emission spectra of AHB were investigated and recorded in dimethylformamide (DMF) at room temperature. The absorption spectrum of pure AHB in DMF shows two peaks at 330nm and 450nm, after adding FA (200μM)...

Embodiment 2

[0035] Example 2 - Fluorescent detection of formaldehyde in the gas phase:

[0036] In solid support, AHB had no fluorescence emission initially, but a fluorescence response at 520 nm was observed after exposure to formaldehyde gas. The fast response property of AHB to formaldehyde gas makes it suitable for the fabrication of portable sensors for detection of aldehyde compounds. A portable sensor was prepared by dropping a drop of DMF solution containing 100 μM AHB onto a filter paper strip. The sensor is ready for use after the DMF has evaporated. The detection sensitivity of the AHB sensor was tested by exposure to formaldehyde vapor in a 1 M formaldehyde solution. Place 0.5 mL of 1M formaldehyde solution in a 20 mL bottle and monitor it for 180 seconds ( Figure 4 with Figure 5 ). The formaldehyde sensor was exposed to formaldehyde vapor in 1M formaldehyde solution for 60 seconds and observed fluorescence emission ( Figure 5 C). Water and air were used as controls ...

Embodiment 3

[0037] Example 3 - Fluorescence detection of formaldehyde in DMF phase:

[0038] The selectivity of AHB to formaldehyde was further verified by adding other aldehyde-containing compounds such as acetic acid, veratraldehyde, heptanal, butyraldehyde, glutaraldehyde, acetophenone, and benzaldehyde. The fluorescence intensity changed the most when formaldehyde was added, and it was also found that glutaraldehyde and acetic acid also showed obvious fluorescence response turn-on phenomenon. Other species such as veratraldehyde, heptanal, butyraldehyde, acetophenone, and benzaldehyde showed weaker changes in fluorescence intensity. Such as Image 6 As shown, under the excitation of 365nm ultraviolet light, AHB has almost no detectable fluorescence emission at 520nm. With the gradual addition of different concentrations of formaldehyde, the fluorescence emission at 520nm was gradually enhanced. By plotting the fluorescence intensity versus formaldehyde concentration, a good linea...

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Abstract

A novel 1, 8-anhydride naphthalene derivative is developed, and the 1, 8-anhydride naphthalene derivative shows opening fluorescence response to formaldehyde in both a solution and a gas phase. In the presence of formaldehyde, a fluorescence response opening phenomenon of the reacted 1, 8-anhydride naphthalene derivative is observed at 520 nm. Through calculation, the detection limit of the probe with the fluorescence opening effect is 38.0 [mu] M.

Description

[0001] Cross References to Related Applications [0002] This application claims priority to Provisional U.S. Patent Application No. 62 / 973,582, filed October 15, 2019, which is hereby incorporated by reference in its entirety into this application for all purposes. technical field [0003] The invention relates to the application of a chemometric instrument, which can be used to monitor formaldehyde in solution and gas phase. Background technique [0004] Formaldehyde (Formaldehyde, FA) is the simplest and smallest molecule containing a carbonyl functional group and is used in construction, furniture coating, textile industry and many chemical industries. Acute inhalation of formaldehyde can cause a variety of health-related problems, such as headaches, difficulty breathing, and throat numbness, and long-term exposure can be fatal or cause cancer. Since it easily interacts with proteins and nucleic acids, causing great damage to cells, formaldehyde is a class of compounds ...

Claims

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Application Information

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IPC IPC(8): C09K11/06G01N21/64
CPCC09K11/06G01N21/643G01N21/6402C09K2211/1029
Inventor 唐本忠帕韦杰·阿拉姆梁力政
Owner THE HONG KONG UNIV OF SCI & TECH
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