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Composition for treating Alzheimer's disease as well as preparation method and application thereof

A technology for Alzheimer's disease and a composition is applied in the field of compositions for the treatment of Alzheimer's disease, which can solve the problem of Alzheimer's disease treatment, the inability to achieve Alzheimer's disease, and the inability to develop specific therapeutic drugs and other issues to achieve convincing safety, prevention of Alzheimer's symptoms, and clear effects

Active Publication Date: 2021-04-30
江苏恒正合生命科学有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Lessons from the failure of numerous clinical trials suggest that single-target therapy is difficult to be effective for Alzheimer's disease, a complex disease
[0004] So far, the cause of Alzheimer's disease has not been elucidated, and no specific therapeutic drug can be developed, so the treatment of Alzheimer's disease has always been a very difficult problem

Method used

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  • Composition for treating Alzheimer's disease as well as preparation method and application thereof
  • Composition for treating Alzheimer's disease as well as preparation method and application thereof
  • Composition for treating Alzheimer's disease as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1A

[0031] The establishment of embodiment 1AD experimental animal model

[0032] The model animal strain is SPF-grade SD rats, healthy, male, weighing 250g-300g, provided by Shanghai Nanfang Model Biotechnology Development Co., Ltd. The experimental groups were divided into normal control group, AD model group, positive drug group, test drug group 1, test drug group 2, and test drug group 3, a total of six groups, with 8 to 11 rats in each group.

[0033] In addition to the normal control group, β-amyloid (specifically Aβ 1-40 , purchased from Sigma Company) injected into the hippocampus to induce rats is a modeling method for AD rats. Specifically, rats were anesthetized by intraperitoneal injection of 10% chloral hydrate solution, with a dosage of 4.5ml / kg. SD rats were anesthetized by intraperitoneal injection of 1% pentobarbital sodium 40 μg / g, and then fixed on a brain stereotaxic apparatus after anesthesia. According to the rat brain stereotaxic atlas, the anterior bregm...

Embodiment 2

[0034] Embodiment 2 Behavioral detection——Morris water maze model test

[0035] The escape latency test was performed in the first 3 days, and the platform was removed from the platform on the 4th day for the cross-platform test.

[0036] 2.1 Escape latency experiment

[0037] The so-called incubation period experiment means that each rat enters the water from the same position in the test, and the experimenter must assist the rat to enter the water slowly. In order to ensure that the environment for rats to swim on the stage is as similar as possible, pay attention to replenishing water and keep the platform 2cm away from the water surface. After the rat enters the water, start timing, find the platform and stay for 2 seconds, and record the time. The time spent is the incubation period, and the platform has not been found after more than 120 seconds It is also recorded as 120 seconds. The shorter the time, the better the memory improvement effect.

[0038] 2.2 Cross-platf...

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Abstract

The present invention provides a composition for treating Alzheimer's disease, comprising beta nicotinamide mononucleotide (NMN) and L [alpha] glycerophosphorylcholine ([alpha] GPC), preferably in an amount of 3-9 mg / kg / d and in an amount of 8-20 mg / kg / d. In a classic Alzheimer's disease pharmacodynamic evaluation model Morris water maze test model, the composition provided by the invention has an obvious improvement effect on learning and memory behaviors of rats after artificial modeling. The composition is a food-grade raw material, is safe and reliable, and can be taken for a long time.

Description

technical field [0001] The invention relates to a composition for treating Alzheimer's disease and its application. Background technique [0002] Alzheimer's disease (hereinafter referred to as AD) was first discovered by German psychiatrist and neuropathologist Alzheimer Alois in 1906 and named after him. It is a chronic neurodegenerative disease. The main clinical manifestations of Alzheimer's disease are memory loss, cognitive dysfunction, abnormal behavior and social impairment. With the increase of the average human life expectancy, the incidence rate is increasing year by year. About 70% of Alzheimer's disease is Alzheimer's disease, there is still vascular dementia, and mixed dementia where the two coexist. Its main pathological features are brain atrophy, senile plaques in brain tissue, cerebral vascular deposits and neurofibrillary tangles. [0003] Current studies have shown that the main pathological features of Alzheimer's patients are the aggregation of β-amyl...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/706A61K31/685A61P25/28A23L33/10
CPCA61K31/706A61K31/685A61P25/28A23L33/10A23V2002/00A61K2300/00A23V2200/322
Inventor 刘义恩张明川王冯哲王聪
Owner 江苏恒正合生命科学有限公司
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