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Protein fibers capable of being prepared on large scale and application thereof

A protein fiber, large-scale preparation technology, applied in the direction of single-component protein rayon, cellulose/protein conjugated rayon, fiber treatment, etc., can solve the problems of complex preparation methods, weak mechanical properties, single function, etc. Achieve the effects of simple preparation process, mild conditions and excellent mechanical properties

Active Publication Date: 2021-04-23
SHAANXI NORMAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The purpose of the present invention is to solve the problems of complex preparation methods, low efficiency, weak mechanical properties and single function of existing protein fibers, and to provide a method that combines rapid amyloid transformation of proteins with wet spinning, which can be fast, efficient, and Multifunctional protein fibers rapidly produced on a large scale and providing new uses for said protein fibers

Method used

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  • Protein fibers capable of being prepared on large scale and application thereof
  • Protein fibers capable of being prepared on large scale and application thereof
  • Protein fibers capable of being prepared on large scale and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] 1. After mixing 1.25g bovine serum albumin, 2mL 500mmol / L tris(2-carboxyethyl)phosphine hydrochloride aqueous solution with pH=5, and 3mL trifluoroethanol, react at 25°C for 30 minutes to generate protein chains Unfolding to obtain a spinning solution.

[0039] 2. Under the driving force of the syringe pump, the spinning solution in step 1 is squeezed into water from the spinneret to obtain primary protein fibers with an amyloid-like structure on a large scale; wherein the diameter of the spinneret is 0.21 mm, and the setting The extrusion flow rate was 1 mL / min.

[0040] 3. Get the nascent protein fiber stretching 3 times in step 2, obtain a large amount of slender macroscopic protein fiber (see figure 1 ). from figure 2 According to the infrared spectrum data, the structure of bovine serum albumin powder is dominated by α-helix, and the β-fold in the formed protein fiber structure is significantly increased, which proves that amyloid transformation has occurred du...

Embodiment 2

[0045] 1. After mixing 1.00 g of bovine serum albumin, 2 mL of 500 mmol / L pH=5 tris(2-carboxyethyl) phosphine hydrochloride aqueous solution, and 3 mL of trifluoroethanol, react at 25°C for 30 minutes to generate protein chains Unfolded to obtain a spinning solution.

[0046] 2. Under the driving force of the syringe pump, the spinning solution in step 1 is squeezed into the water from the spinneret to obtain primary protein fibers with an amyloid-like structure on a large scale; the diameter of the spinneret is 0.51mm, and the The extrusion flow rate was 1 mL / min.

[0047] 3. Take the nascent protein fiber in step 2 and stretch it three times, and after drying, a large number of slender macroscopic protein fibers are obtained. After testing, the fracture strength is 142±17MPa, the Young's modulus is 2.9±0.5GPa, and the toughness is 58±12MJ / m 3 .

Embodiment 3

[0049] In step 1 of this example, 1.25 g of bovine serum albumin, 1 mL of 500 mmol / L pH=4 tris(2-carboxyethyl) phosphine hydrochloride aqueous solution, and 4 mL of trifluoroethanol were mixed and reacted at 25°C The protein chains were unfolded for 30 minutes to obtain a spinning solution. Other steps were the same as in Example 2, and a large number of elongated macroscopic protein fibers were obtained. After testing, the fracture strength is 169±18MPa, the Young's modulus is 2.8±0.6GPa, and the toughness is 53±13MJ / m 3 .

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Abstract

The invention discloses protein fibers capable of being prepared on a large scale and application thereof. A method for preparing the protein fibers on a large scale comprises the following steps that protein, a tris (2-carboxyethyl) phosphine hydrochloride aqueous solution and a spinning solvent are uniformly mixed, and then a protein chain is unfolded to form a spinning solution; the spinning solution is extruded into a coagulating bath from a spinning nozzle under the driving force of an injection pump to assemble a large number of primary protein fibers with amyloid-like structures, and the primary protein fibers are stretched and dried to form protein fibers with excellent mechanical properties. The preparation method can also be used for producing protein hollow fibers for cell culture. Besides, the primary protein fibers are soaked in a graphene oxide dispersion liquid, stretched and dried and then placed in the tris (2-carboxyethyl) phosphine hydrochloride aqueous solution to be reduced to obtain stable conductive protein fibers, and the conductivity of the conductive protein fibers is not changed even under the action of repeated ultrasonic cleaning and 3M adhesive tape tearing. The conductive protein fibers can monitor the stress effect and the temperature and humidity change in real time, and has the potential application of wearable intelligent fabric.

Description

technical field [0001] The invention belongs to the technical field of natural polymer materials, and in particular relates to a protein fiber capable of large-scale preparation and its application. Background technique [0002] With the pursuit of a better life for human beings, smart fibers are already very popular. The voice of "saving energy and protecting the environment" is also getting stronger and stronger, and the shortage of petroleum raw materials and the disadvantages of refractory degradation partially limit the development of synthetic fibers. Therefore, the development of regenerated natural fibers or the use of natural materials to prepare fibers has attracted the interest of many researchers. However, spider silk with excellent mechanical properties is still not available in large quantities. Even though some researchers have developed regenerated silk, its complex preparation process is always time-consuming, labor-intensive and expensive, and the mechani...

Claims

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Application Information

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IPC IPC(8): D01F4/00D01F4/04D01F8/02D01F8/10D01D5/06D01D5/34G01D21/02C12N1/16C12R1/645
Inventor 杨鹏皮和木
Owner SHAANXI NORMAL UNIV
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