A kind of synthetic method of aminoethanethiol

A technology of aminoethanethiol and aminoethanethiol, applied in the synthesis field of aminoethanethiol, can solve problems such as easy self-polymerization, and achieve the effects of promoting ring opening and improving product selectivity

Active Publication Date: 2022-07-12
WANHUA CHEM GRP CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The object of the present invention is to provide a kind of synthetic method of aminoethanethiol, this method solves the problem of easy self-polymerization after ring-opening in the present ethylene sulfide preparation process by introducing novel catalyst, has improved productive rate, has also reduced Cost of production

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0045]Add 20 g of zirconium oxynitrate dihydrate and 100 mL of absolute ethanol into a round-bottomed flask and mix evenly, then add 20 g of ethylene glycol and stir at room temperature for 30 min. mL of ammonium molybdate solution 6.89ml, then heated to 80℃ and stirred for 30min, then added 10% dilute ammonia water dropwise, during the addition process, the solution would gradually become turbid, when the pH value of the reaction system reached 9, stop adding ammonia water dropwise , continue stirring for 24h, filter to obtain stable molybdenum-doped nano-zirconia sol, washed and dried, and calcined in a 400°C muffle furnace for 8h to obtain molybdenum-doped nano-zirconia sol.

[0046] The molybdenum-doped nanocarrier and 250 mL of water were added to a round-bottomed flask, stirred at room temperature for 30 min, then heated to 50 °C, and continued to be stirred for 30 min, and 58.97 mL of 0.25 mol / L precursor nickel nitrate was added to the reaction system, Continue to stir...

Embodiment 2

[0050] Add 20g of tetrabutyl titanate and 100mL of absolute ethanol into a round-bottomed flask and mix well, then add 50mL of deionized water and stir at room temperature for 45min, then heat up to 70°C and stir for 30min, then add HNO dropwise 3 , during the addition process, the solution will gradually become turbid, when HNO 3 When the molar ratio to tetrabutyl titanate is 4, stop adding nitric acid; after stirring for 2 hours, add 1.53 ml of 0.25 g / mL ammonium molybdate solution to the generated colloidal solution according to the doping amount of molybdenum element, and continue stirring 24h, filtered to obtain stable molybdenum-doped nano-TiO 2 The sol was washed and dried, and then calcined in a muffle furnace at 400°C for 7 hours to obtain molybdenum-doped nano-titania.

[0051] The molybdenum-doped nanocarriers and 250 mL of water were added to a round-bottomed flask, stirred at room temperature for 30 min, then heated to 50 °C, and continued to be stirred for 30 mi...

Embodiment 3

[0054] Add 20 g of zirconium oxynitrate dihydrate and 100 mL of absolute ethanol into a round-bottomed flask and mix evenly, then add 20 g of ethylene glycol and stir at room temperature for 60 min. mL of ammonium molybdate solution 7.65ml, then heated to 80°C and stirred for 30min, then 10% dilute ammonia water was added dropwise. During the addition process, the solution would gradually become turbid. When the pH value of the reaction system reached 8, the dropwise addition of ammonia water was stopped. , continue stirring for 24h, filter to obtain stable molybdenum-doped nano-zirconia sol, washed and dried, and calcined in a 400°C muffle furnace for 6h to obtain molybdenum-doped nano-zirconia sol.

[0055] The molybdenum-doped nanocarrier and 250 mL of water were added to a round-bottomed flask, stirred at room temperature for 30 min, then heated to 50 °C, and stirred for 30 min. According to the catalyst loading, 0.25 mol / L of the precursor was added to the reaction system....

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PUM

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Abstract

The invention provides a method for synthesizing aminoethanethiol, a taurine intermediate. In the method, an addition reaction of ethylene sulfide and an ammonia compound is carried out under the catalysis of a modified supported metal catalyst to obtain aminoethanethiol. The method solves the problem of easy self-polymerization of ethylene sulfide after ring-opening, improves the yield and reduces the production cost.

Description

technical field [0001] The invention belongs to the field of preparation of nutritional chemical intermediates, in particular to a method for synthesizing aminoethanethiol. Background technique [0002] Taurine, also known as 2-aminoethanesulfonic acid, is a sulfur-containing non-protein amino acid. Widely present in tissue cells, abundant in the brain. It has functions such as promoting the growth and development of the nervous system and cell differentiation, preventing cardiovascular diseases, affecting lipid absorption, improving immunity, and maintaining normal reproductive needs; therefore, it is widely used in medical treatment, health care, food, etc., and has a good market prospect. [0003] Aminothiols as important intermediates in the synthesis of taurine have been discovered and studied in recent years. In 2007, Hu, L.B. et al. reported a method of using thioacetic acid as a nucleophile to attack polysubstituted aziridines to generate N-acetyl-substituted amino...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07C319/02C07C323/25B01J23/883B01J23/885B01J37/08B01J37/03
CPCY02P20/584
Inventor 蔺海政桂振友郭斌孔令晓丰茂英陈来中张永振
Owner WANHUA CHEM GRP CO LTD
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