Preparation process of organic acid lithium-L-proline salt

Abstract

The invention discloses a preparation process of organic acid lithium-L-proline salt, and relates to the field of synthesis and preparation of organic lithium salt micromolecular medicines. The lithium isobutyrate-L-proline salt is prepared by adopting a single solvent method and a mixed solvent method so as to achieve the purposes of development and clinical application of new organic lithium salt. The organic acid lithium-L-proline salt has positive curative effects and prevention effects on recurrent mania and depression in bipolar affective disorder, has a unique suicide risk prevention effect, can effectively relieve anxiety, depression and other emotional abnormalities, can delay central nervous system degenerative changes, and changes the in vivo distribution defects of existing inorganic lithium salt. In addition, the purpose of modifying the physical and chemical properties of a drug can be achieved by adopting a pharmaceutical eutectic or salifying technology without changingthe public valence structure of drug molecules, the clinical dosage of the lithium salt is reduced while the curative effect of central nervous system diseases is enhanced, and the occurrence of peripheral adverse reactions is avoided.

Description

technical field [0001] The invention belongs to the field of synthesis and preparation of organic lithium salt small molecule drugs, and in particular relates to a preparation process of organic lithium-L-proline salt. Background technique [0002] It is well known that lithium salt not only has a certain curative effect and preventive effect on recurrent episodes of mania and depression in bipolar disorder, but also has a unique effect of preventing suicide risk. Recent studies have found that lithium salt acts on GSK-3, Wnt , Akt and neurotransmitters to play a neuroprotective role, which has potential use in the prevention and treatment of neurodegenerative diseases including Alzheimer's disease. [0003] Lithium salts often require long-term medication in the treatment of mental diseases, and the kidney damage caused by long-term medication greatly limits the clinical application of the drug. It can lead to the disorder of blood pH value, cause metabolic acidosis, and i...

AI Technical Summary

Problems solved by technology

[0003] Lithium salts often require long-term medication in the treatment of mental diseases, and the kidney damage caused by long-term medication greatly limits the clinical application of the drug. It can lead to the disorder of blood pH value, cause metabolic acidosis, and increase the burden on the kidneys. Important impact, can effectively relieve anxiety and depression and other emotional abnormalities, and can delay the degeneration of the central nervous system, and the absorption distribution and metabolic characteristics of organic acid salts are often quite different from those of inorganic acid salts, which is expected to change the existing inorganic acid salts. The in vivo distribution of lithium salts is defective, so organic acid lithium salts have better new drug development value and market prospects

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