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Hydrogel active dressing with antibacterial and anti-inflammatory functions

An antibacterial and anti-inflammatory, hydrogel technology, applied in microcapsules, capsule delivery, medical science and other directions, can solve the problems of bacterial drug resistance, poor mechanical properties of hydrogels, toxic and side effects, etc., and achieve improved mechanical properties and uniform distribution. , the effect of small particle size

Active Publication Date: 2021-02-19
NANFANG HOSPITAL OF SOUTHERN MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In order to ensure its antibacterial performance, people try to assemble different antibiotics into hydrogel dressings, but the long-term application of antibiotics at the infection site will cause bacterial resistance and produce toxic side effects. On the other hand, hydrogels usually It exhibits poor mechanical properties, so it is necessary to develop a hydrogel dressing that does not contain antibiotics, has antibacterial and anti-inflammatory functions, and has good mechanical properties and biocompatibility

Method used

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  • Hydrogel active dressing with antibacterial and anti-inflammatory functions

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preparation example Construction

[0035] Embodiments of the present invention relate to a preparation method of a hydrogel active dressing with antibacterial and anti-inflammatory functions, comprising the following steps:

[0036] S1. Preparation of amyloid fibrils

[0037] Dissolve β-lactoglobulin or whey protein isolate or lysozyme or bovine serum albumin or soybean protein in water to obtain a protein solution, add dilute hydrochloric acid solution dropwise to adjust the pH of the solution to 1.0-4.0, and heat the protein solution in a water bath To 80-95°C, keep warm for 14-24h to obtain amyloid fiber solution;

[0038] S2, polymer preparation

[0039] Weigh 3-5 parts of 2-vinyl-4,6-diamino-1,3,5-triazine, add 100 parts of dimethylformamide or dimethyl sulfoxide to dissolve, add hydroxyethyl acrylate 6 -8 parts, add 0.1-0.4 parts of ammonium persulfate, put the mixed solution in an ice-water bath, stir for 10-40 minutes until fully dissolved, then add 0.01-0.06 parts of tetramethylethylenediamine, conti...

Embodiment 1

[0069] A preparation method of a hydrogel active dressing with antibacterial and anti-inflammatory functions, comprising the following steps:

[0070] S1. Preparation of amyloid fibrils

[0071] Dissolve β-lactoglobulin in water to obtain a protein solution with a mass fraction of 8%, add dropwise dilute hydrochloric acid solution to adjust the pH of the solution to 3.0, heat the protein solution to 85°C by heating in a water bath, and keep it warm for 18 hours to obtain amyloid protein fiber solution;

[0072] S2, polymer preparation

[0073] Weigh 4 parts of 2-vinyl-4,6-diamino-1,3,5-triazine, add 100 parts of dimethylformamide to dissolve, add 7 parts of hydroxyethyl acrylate, add 0.14 parts of ammonium persulfate , put the mixed solution in an ice-water bath, stir for 20 minutes until fully dissolved, then add 0.03 parts of tetramethylethylenediamine, continue to stir and mix evenly, pass nitrogen gas into the mixed solution to remove oxygen, close the reaction system, a...

Embodiment 2

[0081] A preparation method of a hydrogel active dressing with antibacterial and anti-inflammatory functions, comprising the following steps:

[0082] S1. Preparation of amyloid fibrils

[0083] Dissolve β-lactoglobulin in water to obtain a protein solution with a mass fraction of 8%, add dropwise dilute hydrochloric acid solution to adjust the pH of the solution to 3.0, heat the protein solution to 85°C by heating in a water bath, and keep it warm for 18 hours to obtain amyloid protein fiber solution;

[0084] S2, polymer preparation

[0085] Weigh 4 parts of 2-vinyl-4,6-diamino-1,3,5-triazine, add 100 parts of dimethylformamide to dissolve, add 7 parts of hydroxyethyl acrylate, add 0.14 parts of ammonium persulfate , put the mixed solution in an ice-water bath, stir for 20 minutes until fully dissolved, then add 0.03 parts of tetramethylethylenediamine, continue to stir and mix evenly, pass nitrogen gas into the mixed solution to remove oxygen, close the reaction system, a...

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Abstract

The invention provides a hydrogel active dressing with antibacterial and anti-inflammatory functions, and belongs to the field of medical hydrogel dressings. The dressing is prepared by the followingsteps: taking 2-vinyl-4, 6-diamino-1, 3, 5-triazine and hydroxyethyl acrylate as monomers, preparing a linear copolymer by adopting a chemical polymerization method, blending with amyloid protein fibers, generating a loose cross-linked network under the action of a cross-linking agent to form a first gel product, introducing a mixture of carboxymethyl chitosan and a water-soluble polyphenol compound into the loose first gel product, performing freeze-thaw cycle treatment under the combined action of the cross-linking agent in the first gel product, and performing secondary gelation to form cross-linked hydrogel which is mainly subjected to physical cross-linking and is assisted by chemical cross-linking. The mechanical property of the hydrogel dressing is greatly improved, and the hydrogeldressing has good antibacterial, anti-inflammatory and self-recovery functions and is suitable for wound protection and treatment of burns, scalds and traumatic wounds.

Description

technical field [0001] The invention relates to the field of medical hydrogel dressings, in particular to a hydrogel active dressing with antibacterial and anti-inflammatory functions. Background technique [0002] Medical dressings are wound coverings, which replace the damaged skin to play a temporary barrier role in the wound healing process and provide an environment conducive to wound healing. During the wound healing process, the damaged skin is easily infected by bacteria, leading to wound deterioration, Melting veins, and even death of the patient. Therefore, it is very important that medical dressings have good antibacterial properties. [0003] Hydrogel dressing is a new type of wound dressing developed in recent years. It is mainly composed of a gelatinous substance with a three-dimensional network structure formed after the polymer absorbs water and swells. It has a high water content and can keep the wound partially moist. The environment, while absorbing tiss...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L26/00C08F120/34
CPCA61L26/008A61L26/0066A61L26/0052A61L26/0019A61L26/0004C08F120/34A61L2300/104A61L2300/622A61L2300/404A61L2300/412A61L2300/224A61L2300/40Y02A50/30
Inventor 江娴侯晓敏朱丽瑜彭焕椽
Owner NANFANG HOSPITAL OF SOUTHERN MEDICAL UNIV
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