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Preparation method of transdermal drug delivery microneedle preparation of modafinil

A technology of microneedle preparation and transdermal drug delivery, which is applied in the field of medicine, can solve the problems of inability to form a coating layer, insoluble modafinil, and low drug loading, and achieve rapid onset of action, short swelling time, and drug delivery. stable effect

Active Publication Date: 2021-02-19
ACADEMY OF MILITARY MEDICAL SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, no one has made modafinil into microneedles, because modafinil has the defects of insoluble, low drug loading, and inability to form a coating layer.

Method used

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  • Preparation method of transdermal drug delivery microneedle preparation of modafinil
  • Preparation method of transdermal drug delivery microneedle preparation of modafinil
  • Preparation method of transdermal drug delivery microneedle preparation of modafinil

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Effect test

Embodiment 1

[0037] The preparation method of the microneedle preparation for transdermal administration of modafinil comprises:

[0038] 1) Dissolve modafinil in methanol to prepare a 45 mg / mL modafinil solution, add PVP k90 to stir and swell, and prepare a 0.12 g / mL PVP k90 solution;

[0039] 2) The PVP k90 solution is poured into a cylindrical mold with a tip, vacuumed, dried, and demolded to obtain the product.

Embodiment 2

[0041] The preparation method of the microneedle preparation for transdermal administration of modafinil comprises:

[0042] 1) Dissolve modafinil in methanol to prepare a 50 mg / mL modafinil solution, add PVP k90 to stir and swell to prepare a 0.18 g / mL PVP k90 solution;

[0043] 2) The PVP k90 solution is poured into a pyramid-shaped mold, vacuumed, dried, and demolded to obtain the product.

Embodiment 3

[0045] The preparation method of the microneedle preparation for transdermal administration of modafinil comprises:

[0046] 1) Dissolve modafinil in methanol to prepare a 48 mg / mL modafinil solution, add PVP k90 to stir and swell to prepare a 0.15 g / mL PVP k90 solution;

[0047] 2) The PVP k90 solution is poured into a conical mold, vacuumed, dried, and demolded to obtain the product.

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Abstract

The invention discloses a preparation method of a transdermal drug delivery microneedle preparation of modafinil. The preparation method comprises the following steps: 1) dissolving modafinil with methanol to prepare a 45-50 mg / mL modafinil solution, adding PVP k90, and performing stirring and swelling to prepare a 0.12-0.18 g / mL PVP k90 solution; and 2) pouring the PVP k90 solution into a mold, and carrying out vacuumizing, drying and demolding to obtain the product. The soluble microneedle with good hollow performance can be formed, the effect is achieved quickly, the medicine effect is stable, and the effects of the modafinil on waking up and maintaining the cognitive level are achieved. PVP k90 is used for preparing the soluble microneedle for the first time, the use amount is small, the swelling time is short, and the soluble microneedle can be formed, complete and smooth by single use. Meanwhile, the drug loading capacity of the microneedle prepared by dissolving the drug with methanol and PVP is improved, a certain mechanical strength is maintained to pierce the skin, and modafinil adopts a patch form for the first time, so that the advantages of the microneedle patch are embodied.

Description

technical field [0001] The present invention relates to the field of medicine. More specifically, the present invention relates to a preparation method of a microneedle preparation for transdermal administration of modafinil. Background technique [0002] A microneedle is a needle-like projection with a length between 50 and 900 microns, which realizes transdermal drug delivery by puncturing the skin, and it only pierces the stratum corneum of the skin without hurting the nerves during the puncture process. The drug fully enters the body to play a role, and has the advantages of quickness, convenience, object and minimal trauma. Modafinil is an awakening agent that maintains the cognitive level in the awakened state. It is usually administered through oral intake and excreted through the liver and kidneys. Due to the absorption and availability of oral drugs, each person has an individual The difference is that when taking it, you need to take it several times to see the e...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/00A61K9/70A61K31/165A61K47/32A61P25/00
CPCA61K9/0021A61K9/7023A61K31/165A61K47/32A61P25/00
Inventor 杜丽娜朱林金义光于翔
Owner ACADEMY OF MILITARY MEDICAL SCI
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