Bone targeting nano material and application thereof
A nano-material and bone-targeting technology, applied in bone diseases, medical preparations with non-active ingredients, medical preparations containing active ingredients, etc., can solve the medical expenses of poor drug permeability, systemic toxicity, and drug resistance risks To achieve the effect of inhibiting bone resorption, good application prospects, and promoting bone formation
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[0019] 1 Preparation of PEG-PLGA-AL-CAT
[0020] Weigh 1g PLGA and dissolve in 32ml dichloromethane, add 65mg 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride (EDC), 42.5mg N-hydroxysuccinyl amine (NHS), and then stirred at room temperature for 1 hour, added 12 mg of AL, stirred overnight at room temperature, dialyzed for 48 hours, and vacuum freeze-dried to obtain AL-PLGA.
[0021] Accurately weigh 50mg AL-PLGA and 50mg mPEG-PLGA and dissolve in 1.25mL ethyl acetate, add 2.0mg CAT as the organic phase. Add dropwise into 5mL 2% polyvinyl alcohol aqueous solution, stir at room temperature for 1h, emulsify for 30s using ultrasonic emulsifier, disperse in 20ml deionized water, stir overnight at room temperature, remove the organic solvent ethyl acetate by volatilization, and centrifuge at 5000rpm for 10min to obtain Bone targeting nanomaterials.
[0022] 2 Physicochemical properties and morphology of nanoparticles
[0023] Take an appropriate amount of prepared nano...
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