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Bone targeting nano material and application thereof

A nano-material and bone-targeting technology, applied in bone diseases, medical preparations with non-active ingredients, medical preparations containing active ingredients, etc., can solve the medical expenses of poor drug permeability, systemic toxicity, and drug resistance risks To achieve the effect of inhibiting bone resorption, good application prospects, and promoting bone formation

Pending Publication Date: 2021-02-05
XUZHOU MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Bone tissue has less blood supply and poor drug permeability. Therefore, in order to maintain the effective concentration in bone tissue, the dose needs to be increased, which increases the risk of systemic toxicity, drug resistance and corresponding medical expenses.

Method used

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  • Bone targeting nano material and application thereof
  • Bone targeting nano material and application thereof
  • Bone targeting nano material and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] 1 Preparation of PEG-PLGA-AL-CAT

[0020] Weigh 1g PLGA and dissolve in 32ml dichloromethane, add 65mg 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride (EDC), 42.5mg N-hydroxysuccinyl amine (NHS), and then stirred at room temperature for 1 hour, added 12 mg of AL, stirred overnight at room temperature, dialyzed for 48 hours, and vacuum freeze-dried to obtain AL-PLGA.

[0021] Accurately weigh 50mg AL-PLGA and 50mg mPEG-PLGA and dissolve in 1.25mL ethyl acetate, add 2.0mg CAT as the organic phase. Add dropwise into 5mL 2% polyvinyl alcohol aqueous solution, stir at room temperature for 1h, emulsify for 30s using ultrasonic emulsifier, disperse in 20ml deionized water, stir overnight at room temperature, remove the organic solvent ethyl acetate by volatilization, and centrifuge at 5000rpm for 10min to obtain Bone targeting nanomaterials.

[0022] 2 Physicochemical properties and morphology of nanoparticles

[0023] Take an appropriate amount of prepared nano...

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PUM

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Abstract

The invention relates to a nano material and application thereof, in particular to a bone targeting nano material. The bone targeting nano material comprises catalpol, alendronate sodium, polyethyleneglycol and a poly (lactic-co-glycolic acid) copolymer. TEM (transmission electron microscope) detection and diabetes mouse osteoporosis model pharmacodynamic experiments prove that the material can be better distributed in bone tissue, has a remarkable treatment effect, and has good open prospect.

Description

technical field [0001] The invention relates to a bone-targeting nanometer material and its application, in particular to a nanometer material carrying catalpol. Background technique [0002] Catalpol, English name Catalpol, molecular formula: C 15 h 22 o 10 ,Molecular weight: 362.329. The structural formula is as follows: [0003] [0004] Catalpol is the main active ingredient of traditional Chinese medicine Rehmannia glutinosa, belonging to iridoids. The 2010 edition of "Chinese Pharmacopoeia" pointed out that catalpol is one of the indicators for the quality control of rehmannia glutinosa. This compound has a wide range of biological activities, including hypoglycemic, neuroprotective, anti-aging, anti-tumor and anti-osteoporosis effects. Studies have shown that catalpol can significantly improve diabetes complications such as diabetic hyperglycemia, diabetic liver disease, kidney disease, cardiovascular system disease and diabetic osteoporosis, and animal experi...

Claims

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Application Information

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IPC IPC(8): A61K47/59A61K47/69A61K31/7048A61K31/663A61P19/08A61P19/10
CPCA61K47/593A61K47/6907A61K47/6935A61K31/7048A61K31/663A61P19/08A61P19/10A61K2300/00
Inventor 印晓星赵璐杜伟季学燕
Owner XUZHOU MEDICAL UNIV
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