Specific anti-porphyromonas gingivalis egg yolk antibody liposome solution and preparation method thereof

Abstract

The invention relates to a specific anti-porphyromonas gingivalis egg yolk antibody liposome solution and a preparation method thereof, and belongs to the field of medicines for treating periodontitis. Each milliliter of the egg yolk antibody liposome solution contains 4mg of egg yolk antibody liposome, and the egg yolk antibody liposome is a multi-chamber liposome; the egg yolk antibody liposomesolution is a fluid at a temperature lower than room temperature and forms gel at a temperature of 37 DEG C, so that the requirements of injection administration and in-vivo gelatinization in the periodontal pocket are met, the concentration in the periodontal pocket is effectively improved, and the dose is reduced. The preparation method comprises the following steps: using lecithin and cholesterol as raw materials and tocopherol as a stabilizer, and preparing a liposome film by a film dispersion method; coating the egg yolk antibody with the liposome film to prepare an egg yolk antibody liposome capsule, and reforming the formed liposome capsule by using a homogenizer to obtain the specific anti-porphyromonas gingivalis egg yolk antibody liposome solution, wherein the egg yolk antibody liposome is a nano-scale liposome.

Description

technical field [0001] The invention belongs to the field of drugs for treating periodontitis, and in particular relates to a specific anti-Porphyromonas gingivalis yolk antibody liposome solution (anti-Pg-IgY liposome) and a preparation method thereof. Background technique [0002] Periodontal disease is a bacterial infectious disease, and among the more than 700 known species of oral microorganisms, only a few bacteria (about 30 species) are closely related to the occurrence and development of periodontitis, which makes the immunology of periodontitis Prevention and treatment are possible. Periodontal mechanical treatment can remove most of the plaque and calculus, but for moderate to severe periodontitis, due to the complexity of the root surface structure, it is difficult for instruments to reach the deepest part of the infection and cannot completely control the infection. Adjuvant drug therapy is required in this case. Years of research and practical experience have ...

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Problems solved by technology

However, since the immunity provided by passive immunization is exogenous, it is easy to be eliminated and the immune effect time is short

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