Specific anti-porphyromonas gingivalis egg yolk antibody liposome solution and preparation method thereof

A technology of egg yolk antibody and gingival porphyrin, which is applied in the field of medicine for the treatment of periodontitis, can solve the problems of short immune action time, achieve the effects of enhancing bioavailability, prolonging action time, and improving pregnancy safety

Pending Publication Date: 2021-01-29
安徽医科大学附属口腔医院
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, since the immunity provided by passive immunization is ex...

Method used

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  • Specific anti-porphyromonas gingivalis egg yolk antibody liposome solution and preparation method thereof
  • Specific anti-porphyromonas gingivalis egg yolk antibody liposome solution and preparation method thereof
  • Specific anti-porphyromonas gingivalis egg yolk antibody liposome solution and preparation method thereof

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Embodiment Construction

[0029] The present invention will be further described below by embodiment.

[0030] Reagents and equipment

[0031]Specific anti-Porphyromonas gingivalis egg yolk antibody solution (Anhui Anke Bioengineering Co., Ltd.); lecithin (Germany Libao De company); cholesterol (biological reagent pure, Canada BBI company); chloroform, tocopherol And other reagents (Tianjin Bodi Chemical Technology Co., Ltd.); dialysis bags (Shanghai Yuanye Biotechnology Co., Ltd.). Dynamic light scattering particle size distribution analyzer (Brookhaven Instruments, USA), constant temperature magnetic stirrer (Changzhou Zhiborui Instrument Co., Ltd.); N-1001 rotary evaporator (EYELA, Japan); eddy current oscillator (Changzhou Shenguang Instrument Co., Ltd. company); Mettler AE240 electronic balance (Shanghai Youyi Instrument Co., Ltd.);

[0032] Preparation method of liposome

[0033] (1) Preparation of lipid film

[0034] Precisely weigh 120 mg of soybean lecithin and 15 mg of cholesterol (the ra...

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Abstract

The invention relates to a specific anti-porphyromonas gingivalis egg yolk antibody liposome solution and a preparation method thereof, and belongs to the field of medicines for treating periodontitis. Each milliliter of the egg yolk antibody liposome solution contains 4mg of egg yolk antibody liposome, and the egg yolk antibody liposome is a multi-chamber liposome; the egg yolk antibody liposomesolution is a fluid at a temperature lower than room temperature and forms gel at a temperature of 37 DEG C, so that the requirements of injection administration and in-vivo gelatinization in the periodontal pocket are met, the concentration in the periodontal pocket is effectively improved, and the dose is reduced. The preparation method comprises the following steps: using lecithin and cholesterol as raw materials and tocopherol as a stabilizer, and preparing a liposome film by a film dispersion method; coating the egg yolk antibody with the liposome film to prepare an egg yolk antibody liposome capsule, and reforming the formed liposome capsule by using a homogenizer to obtain the specific anti-porphyromonas gingivalis egg yolk antibody liposome solution, wherein the egg yolk antibody liposome is a nano-scale liposome.

Description

technical field [0001] The invention belongs to the field of drugs for treating periodontitis, and in particular relates to a specific anti-Porphyromonas gingivalis yolk antibody liposome solution (anti-Pg-IgY liposome) and a preparation method thereof. Background technique [0002] Periodontal disease is a bacterial infectious disease, and among the more than 700 known species of oral microorganisms, only a few bacteria (about 30 species) are closely related to the occurrence and development of periodontitis, which makes the immunology of periodontitis Prevention and treatment are possible. Periodontal mechanical treatment can remove most of the plaque and calculus, but for moderate to severe periodontitis, due to the complexity of the root surface structure, it is difficult for instruments to reach the deepest part of the infection and cannot completely control the infection. Adjuvant drug therapy is required in this case. Years of research and practical experience have ...

Claims

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Application Information

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IPC IPC(8): A61K39/40A61K9/127A61P31/04A61P1/02B82Y5/00B82Y40/00
CPCA61K39/40A61K9/127A61P31/04A61P1/02B82Y5/00B82Y40/00
Inventor 徐燕刘新华桂双英韩旭徐涵颖王腾飞胡韶光霍冬梅辛保见蒋鹏
Owner 安徽医科大学附属口腔医院
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