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Scaffold material for bone tissue engineering and preparation method thereof

A bone tissue engineering and scaffold material technology, applied in the field of biomedical materials, can solve the problem of not developing bone tissue engineering scaffold materials, etc., to promote osteogenic differentiation and extracellular matrix mineralization, promote the generation of new bone tissue, promote The effect of bone repair

Inactive Publication Date: 2021-01-08
杭州鹿扬科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although there have been many studies on tissue engineering scaffold materials in recent years, an ideal scaffold material for bone tissue engineering has not yet been developed.

Method used

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  • Scaffold material for bone tissue engineering and preparation method thereof
  • Scaffold material for bone tissue engineering and preparation method thereof
  • Scaffold material for bone tissue engineering and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] Preparation of chitosan derivatives:

[0037] Disperse cucurbit [6] urea and potassium persulfate (mass ratio 1:1.2) in water, the amount of water used is 25 times the mass of cucurbit [6] urea, nitrogen gas 30min; then add chitosan derivatives (addition amount 0.05g / mL), under the protection of nitrogen, heated and stirred for 10 hours, filtered to remove insoluble matter after the reaction, and collected the clear liquid; after diluting the clear liquid, dialyzed in dilute potassium sulfate solution for 48 hours, and the dialysis bag The substance in the mixture was poured into 10 times the volume of precipitant for precipitation, and the solid obtained after suction filtration was repeatedly washed with water and precipitant for 5 times for purification to obtain chitosan derivatives. The grafting rate of cucurbit [6] urea-grafted chitosan was determined to be 64% by infrared spectroscopy.

[0038] Preparation of graphene oxide solution:

[0039] Take graphene oxid...

Embodiment 2

[0043] The difference between the preparation of chitosan derivatives and Example 1 is that cucurbit [7] urea is used instead of cucurbit [6] urea, and the grafting rate is 56%.

[0044] The preparation of graphene oxide solution is identical with embodiment 1.

[0045]The difference between the preparation of the scaffold material for bone tissue engineering and Example 1 is that the mass of meteorite powder and graphene oxide is 9% and 0.6% of the mass of chitosan derivative, respectively.

Embodiment 3

[0047] The difference between the preparation of chitosan derivatives and Example 1 is that cucurbit [8] urea is used instead of cucurbit [6] urea, and the grafting rate is 52%.

[0048] The preparation of graphene oxide solution is identical with embodiment 1.

[0049] The difference between the preparation of the scaffold material for bone tissue engineering and that of Example 1 is that the mass of meteorite powder and graphene oxide are respectively 10% and 0.8% of the mass of chitosan derivative.

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Abstract

The invention discloses a scaffold material for bone tissue engineering and a preparation method thereof, and relates to the technical field of biomedical materials. The scaffold material comprises: achitosan derivative prepared by grafting cucurbit[n]uril to chitosan, where n = 5-8, graphene oxide and stone needle powder. The specific preparation method comprises the following steps: taking a chitosan derivative solution, adding stone needle powder and graphene oxide, and carrying out ultrasonic treatment; and then adding glycerol, fully and uniformly mixing, defoaming, freezing and drying to obtain the scaffold material. According to the present invention, the scaffold material has relatively high porosity, strong bone conductivity, and high bone induction activity, can induce bone cells to grow into the material and promote the formation of new bone tissue, and has the advantages of favorable biocompatibility, excellent mechanical properties, no toxicity and biodegradability.

Description

technical field [0001] The invention belongs to the technical field of biomedical materials, and in particular relates to a scaffold material for bone tissue engineering and a preparation method thereof. Background technique [0002] The treatment of bone defects has always been one of the clinical problems in orthopedics. There are tens of millions of patients with fractures and bone defects worldwide every year. The traditional treatment methods mainly include autologous bone transplantation, allogeneic bone transplantation, and artificial bone transplantation. However, these methods have major defects. As the "gold standard" of bone transplantation technology, autologous bone transplantation has defects such as new lesions, limited sources, bone area infection, pain, and long operation time; Severe immune rejection, etc.; artificial bone grafts have defects such as limited sources, difficulty in osteogenesis, and large variation in porosity of raw materials. Due to vari...

Claims

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Application Information

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IPC IPC(8): A61L27/02A61L27/08A61L27/20A61L27/50A61L27/56A61L27/58
CPCA61L27/025A61L27/08A61L27/20A61L27/50A61L27/56A61L27/58A61L2430/02C08L5/08
Inventor 不公告发明人
Owner 杭州鹿扬科技有限公司
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