Formula and preparation process of mitochondrion oral solid preparation

A solid preparation, mitochondrial technology, which is applied in pharmaceutical formulations, pill delivery, medical preparations containing active ingredients, etc., can solve problems such as difficulty in ensuring drug quality, poor accuracy of finished product loading detection, and poor quality controllability. Achieve the effect of protecting and mitochondrial function, safety, effectiveness and quality stability, and protecting cells

Inactive Publication Date: 2021-01-05
武汉林宝莱生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

The oral solid preparation containing itraconazole and its preparation method in the above patents have the following disadvantages: the quality controllability in the production process is poor and the accuracy of the finished product loading detection is not good, and it is difficult to guarantee the quality of the drug

Method used

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  • Formula and preparation process of mitochondrion oral solid preparation

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Effect test

Embodiment 1

[0056] A Mitochondrial Oral Solid Preparation Formulation, such as figure 1 As shown, it includes the following components by weight: 25 parts of NADH, 30 parts of NR, 20 parts of pomegranate polyphenol, 55 parts of erythritol, 100 parts of microcrystalline cellulose, 5 parts of silicon dioxide, and the balance is water.

[0057] The preparation method of described NADH, comprises the steps:

[0058] S11: Add the same amount of boiling water to the freshly squeezed yeast under stirring, heat to 95°C and keep it warm for 5 minutes, quickly add ice cubes twice the weight of the yeast and filter, wash the filter cake twice with water, combine the filtrate and washing liquid, and add strong alkali Quaternary ammonium type I anion exchange resin 201 × 7, filtered after stirring for 16 hours, and collected the filtrate;

[0059] S12: Adjust the filtrate to PH=2-2.5 with concentrated hydrochloric acid, absorb it on a weakly acidic acrylic cation exchange resin 122 column, wash it wi...

Embodiment 2

[0099] A Mitochondrial Oral Solid Preparation Formulation, such as figure 1 As shown, it includes the following components by weight: 20 parts of NADH, 20 parts of NR, 25 parts of pomegranate polyphenol, 60 parts of erythritol, 103 parts of microcrystalline cellulose, 6 parts of silicon dioxide, and the balance is water.

[0100] The preparation method of described NADH, comprises the steps:

[0101] S11: Add the same amount of boiling water to the freshly squeezed yeast under stirring, heat to 95°C and keep it warm for 5 minutes, quickly add ice cubes twice the weight of the yeast and filter, wash the filter cake twice with water, combine the filtrate and washing liquid, and add strong alkali Quaternary ammonium type I anion exchange resin 201 × 7, filtered after stirring for 16 hours, and collected the filtrate;

[0102] S12: Adjust the filtrate to PH=2-2.5 with concentrated hydrochloric acid, absorb it on a weakly acidic acrylic cation exchange resin 122 column, wash it wi...

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Abstract

The invention discloses a formula and preparation process of a mitochondrion oral solid preparation, and relates to the technical field of pharmaceutical preparations. The problem of poor quality controllability is solved. The formula of the mitochondrion oral solid preparation comprises the following components in parts by weight: 25 parts of NADH, 30 parts of NR, 20 parts of pomegranate polyphenol and 55 parts of erythritol. The preparation process of the mitochondrion oral solid preparation comprises the following steps: weighing the raw materials in parts by weight, crushing the raw materials, and performing sieving with a 100-mesh sieve to obtain fine medicament powder for later use. The raw materials are dried to obtain fine powder, then the fine powder of the components is mixed, granulated, dehydrated and granulated in proportion, the preparation process is simple, the finished product rate and quality accuracy of the preparation are improved, besides, intermediate quantitativecontrol of the product quality and finished product loading detection are better facilitated, therefore, the safety effectiveness and quality stability of the product are good, and industrial production is facilitated.

Description

technical field [0001] The invention relates to the technical field of pharmaceutical preparations, in particular to a formulation of a mitochondrial oral solid preparation and a preparation process thereof. Background technique [0002] At present, the absorption rate of oral solid preparations depends on the dissolution rate of active substances from solid preparations, and the dissolution rate of active ingredients often depends on the disintegration rate of solid preparations. Therefore, it can basically be considered that the disintegration rate of oral solid preparations is the Most of the disintegrants have good water absorption and swelling properties. The role of disintegrants in oral solid preparations is to eliminate or destroy the binding force caused by adhesives or high compression. Make it rapidly disintegrate into fine granular substances in the dissolution medium. The disintegration mechanism of the disintegrant is mainly capillary action and expansion. The ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7076A61K31/706A61K36/185A61K9/20A61P25/20A61P25/00
CPCA61K9/2018A61K31/706A61K31/7076A61K36/185A61K2236/333A61P25/00A61P25/20A61K2300/00
Inventor 雷国平
Owner 武汉林宝莱生物科技有限公司
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