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Orally disintegrating tablet of choline glycerophosphate and preparation method thereof

A technology of choline alfoscerate and orally disintegrating tablets, which is applied in the field of orally disintegrating tablets of choline alfoscerate and its preparation, which can solve the problems of reduced curative effect, "false drug taking, and difficulty in swallowing", and achieve improvement of medication experience and taste Good acceptance, solve the effect of bad taste

Pending Publication Date: 2020-12-29
BEIJING VENTUREPHARM BIOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Among the currently marketed choline alfoscerate preparations, soft capsules and tablets are the main ones, and their disintegration speed is slow, so they are not suitable for patients with dysphagia or special conditions. Common problem because it is often accompanied by dysphagia or "fake drug" features
In order to facilitate patients and solve practical problems in treatment, orally disintegrating tablets with the advantages of fast disintegration speed and rapid drug efficacy have been developed, which can effectively improve patient compliance and disintegrate in the oral cavity to solve the problem of "false medication" for mental patients. "Problems, but there are still some problems that have not been resolved, such as poor taste, the obvious decrease in the dissolution rate after long-term storage, the curative effect is reduced, and the safety problems caused by the obvious increase of related substances, etc.

Method used

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  • Orally disintegrating tablet of choline glycerophosphate and preparation method thereof
  • Orally disintegrating tablet of choline glycerophosphate and preparation method thereof
  • Orally disintegrating tablet of choline glycerophosphate and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0064]

[0065] Preparation method: (1) Take the recipe amounts of choline alfoscerate, mannitol, silicified microcrystalline cellulose, croscarmellose sodium, silicon dioxide, and sucralose and mix in a three-dimensional mixer for 20 minutes;

[0066] (2) The magnesium stearate of the recipe quantity is added to the mixed granules prepared in step (1), mixed for 5 minutes, and pressed into tablets.

Embodiment 2

[0068]

[0069] (1) get the recipe quantities of choline alfoscerate, mannitol, silicified microcrystalline cellulose, croscarmellose sodium, silicon dioxide, sucralose and mix in a three-dimensional mixer for 20 minutes;

[0070] (2) The magnesium stearate of the recipe quantity is added to the mixed granules prepared in step (1), mixed for 5 minutes, and pressed into tablets.

Embodiment 3

[0072]

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PUM

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Abstract

The invention provides an orally disintegrating tablet of choline glycerophosphate and preparation method thereof, which includes components of aripiprazole, silicified microcrystalline cellulose, cross linked sodium carboxymethyl cellulose, silica, fillers, flavoring agents and lubricating agents, and the aripiprazole is used as active component. On the basis of the formula, the product is prepared by powder direct pressing process. The product has better taste and more excellent long-term stability, so that the effectiveness and safety of the medicine are guaranteed.

Description

technical field [0001] The invention relates to the field of pharmaceutical preparations, in particular to an orally disintegrating tablet of choline alfoscerate and a preparation method thereof. Background technique [0002] Choline alfoscerate is a psychostimulant that activates the central nervous system of elderly patients, which contains choline and phosphorylcholine precursors. It can effectively act on the prevention and treatment of biochemical lesions. It can clearly identify the pathological factors of various symptoms caused by organ degeneration, thereby reducing choline tone and changing the phospholipid structure of the nerve mucosa. Unlike other forms of choline, choline alfoscerate can easily enter the blood-brain barrier under normal conditions. The chemical structure of glyceryl phosphorylcholine and its related chemical and physical properties provide sufficient nutrients for the protection of brain tissue to complete normal metabolism. The results of p...

Claims

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Application Information

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IPC IPC(8): A61K9/20A61K31/685A61K47/38A61K47/04A61K47/26A61P1/16A61P25/28
CPCA61K31/685A61K9/0056A61K9/2054A61K9/2018A61K9/2009A61P1/16A61P25/28
Inventor 李月彤王宇杰
Owner BEIJING VENTUREPHARM BIOTECH
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