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Dry powder based on yersinia pestis attenuated vaccine and preparation method of dry powder

The technology of an attenuated vaccine and a live attenuated vaccine is applied in the field of dry powder based on the attenuated plague vaccine and its preparation, and achieves the effects of low cost, good preservation and transportation, and weak hygroscopic ability

Pending Publication Date: 2020-12-25
吉林省地方病第一防治研究所
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] However, the existing dry powder is only aimed at the plague virus, and after the human body is invaded by the plague virus, it needs to relieve the surface, clear away heat and detoxify, so as to make the body recover better

Method used

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  • Dry powder based on yersinia pestis attenuated vaccine and preparation method of dry powder
  • Dry powder based on yersinia pestis attenuated vaccine and preparation method of dry powder

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] The preparation method based on the dry powder of plague attenuated vaccine comprises the following steps:

[0038] (1) Take by weighing Yersinia pestis live attenuated vaccine, 5 grams of oligosaccharides, oligosaccharides are the mixture of sucrose and lactose, the weight ratio of sucrose and lactose is 5:3, 8 grams of tyrosine, vitamin B1210 grams, mix 15 grams of colloid, the mixed colloid is a mixture of tara gum, xanthan gum and carrageenan, the weight ratio of tara gum, xanthan gum and carrageenan is 4:5:3, 5 grams of casein hydrolyzate, hard emulsifier 10 grams of sodium fatty lactylate, 1 gram of glycerin, 2 grams of zinc, 6 grams of tea polyphenols, 10 grams of water, 2 grams of citric acid, 10 grams of honeysuckle, 10 grams of Scutellaria baicalensis, 4 grams of Coptis chinensis, 4 grams of Radix Radix, 10 grams of forsythia, Yuan ginseng 1 gram;

[0039] (2) The live attenuated Yersinia pestis vaccine, oligosaccharides, tyrosine, vitamin B12, mixed colloids...

Embodiment 2

[0044] The preparation method based on the dry powder of plague attenuated vaccine comprises the following steps:

[0045](1) Take by weighing Yersinia pestis live attenuated vaccine, 8 grams of oligosaccharides, oligosaccharides are the mixture of sucrose and lactose, the weight ratio of sucrose and lactose is 5:3, 11 grams of valine, 12 grams of vitamin C, mixed 23 grams of colloid, the mixed colloid is a mixture of tara gum, xanthan gum and carrageenan, the weight ratio of tara gum, xanthan gum and carrageenan is 4:5:3, 7 grams of casein hydrolyzate, hard emulsifier Sodium fatty lactylate 13 grams, glycerin 2 grams, iodine 3 grams, vitamin E 7 grams, water 12 grams, sodium bicarbonate 3 grams, honeysuckle 12 grams, Scutellaria baicalensis 13 grams, Coptis 5 grams, Radix Radix 5 grams, Forsythia 12 grams, yuan Ginseng 2 grams;

[0046] (2) The live attenuated Yersinia pestis vaccine, oligosaccharides, valine, vitamin C, mixed colloid, casein hydrolyzate, emulsifier, glyceri...

Embodiment 3

[0051] The preparation method based on the dry powder of plague attenuated vaccine comprises the following steps:

[0052] (1) Weighing: live attenuated Yersinia pestis vaccine, 10 grams of oligosaccharides, the oligosaccharides are a mixture of sucrose and lactose, the weight ratio of sucrose and lactose is 5:3, 15 grams of phenylalanine, and 15 grams of vitamin E , 30 grams of mixed colloids, the mixed colloids are the mixture of tara gum, xanthan gum and carrageenan, the weight ratio of tara gum, xanthan gum and carrageenan is 4:5:3, 9 grams of casein hydrolyzate, hard Calcium Fatty Lactate 15g, Glycerin 3g, Iron 4g, Butylated Hydroxyanisole 9g, Water 15g, Sorbic Acid 4g, Honeysuckle 15g, Scutellaria baicalensis 15g, Coptidis 6g, Banlangen 6g, Forsythia 15 grams, 3 grams of ginseng;

[0053] (2) The live attenuated Yersinia pestis vaccine, oligosaccharide, phenylalanine, vitamin E, mixed colloid, casein hydrolyzate, emulsifier, glycerin, iron, antioxidant, water and pH adj...

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Abstract

The present invention discloses dry powder based on a yersinia pestis attenuated vaccine. The dry powder is prepared from the following raw materials in parts by weight: a group A of raw materials anda group B of raw materials; the group A of the raw materials comprise a live yersinia pestis attenuated vaccine, 5-10 parts of oligosaccharide, 8-15 parts of amino acids, 10-15 parts of vitamins, 15-30 parts of mixed colloid, 5-9 parts of a casein hydrolysate, 10-15 parts of an emulsifier, 1-3 parts of glycerol, 2-4 parts of trace elements, 6-9 parts of an antioxidant, 10-15 parts of water and 2-4 parts of a pH regulator; and the group B of the raw materials comprise 10-15 parts of honeysuckle flowers, 10-15 parts of radix scutellariae, 4-6 parts of rhizoma coptidis, 4-6 parts of radix isatidis, 10-15 parts of fructus forsythiae and 1-3 parts of radix scrophulariae. The dry powder based on the yersinia pestis attenuated vaccine is low in water content, weak in moisture absorption capacityand beneficial to storage and transportation, has effects of relieving exterior syndromes and clearing away heat and toxic materials on body of a patient while aiming at yersinia pestis, improves a cure rate, and is suitable for patients of all ages.

Description

technical field [0001] The invention belongs to the field of biotechnology, and more specifically relates to a dry powder based on attenuated plague vaccine and a preparation method thereof. Background technique [0002] Plague is a severe infectious disease caused by Yersinia pestis infection. It is an international quarantine infectious disease and is also a Class A infectious disease among the legal infectious diseases in China, ranking first in the legal infectious diseases. Plague is a natural foci infectious disease, which is mainly prevalent among rodents. Rats and marmots are the natural hosts of Yersinia pestis, and rat fleas are the media. The clinical manifestations are high fever, swollen lymph nodes, cough, sputum, dyspnea, bleeding, and other severe symptoms of toxemia. The disease is highly contagious and has a high fatality rate. There have been many epidemics before liberation, which have been greatly reduced at present, but sporadic cases still occur in the...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K39/02A61K9/14A61K47/42A61P31/04A61P11/00A61P29/00A61P39/02
CPCA61K39/0291A61K36/355A61K36/539A61K36/718A61K36/195A61K36/315A61K36/634A61K36/808A61K9/146A61P31/04A61P11/00A61P29/00A61P39/02A61K9/0075A61K2039/522A61K2300/00Y02A50/30
Inventor 王照王铁峰关心邵奎东唐丹袁英良
Owner 吉林省地方病第一防治研究所
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