Application of polypeptide in medicine for treating eye inflammation

Abstract

The invention discloses an application of a polypeptide in a medicine for treating eye inflammation. The amino acid sequence of the polypeptide is YGRKKRRQRRRMMPYSTELIFYIEMDP. Eye drops prepared fromthe polypeptide comprise the following components in percentage by weight: 0.05-1% of polypeptide, and the eye inflammation is conjunctivitis, keratitis and / or uveitis. In the polypeptide eye drops, the pharmacological action of the polypeptide in treatment of inflammation is to inhibit inflammation from participating in cell proliferation, inhibit NF-kB activation, inhibit the generation and secretion of various inflammatory mediators, inhibit the growth of new capillaries, inhibit the aggregation and infiltration of inflammatory cells and the like. The polypeptide eye drops are clear in pharmacology, good in curative effect, low in side effect, stable in biological activity of bulk drugs, simple in production process, low in cost and beneficial to large-scale clinical application and reduction of burden of patients.

Description

technical field [0001] The invention belongs to the field of biomedicine, and in particular relates to the application of a polypeptide in medicine for treating ocular inflammation. Background technique [0002] Eye inflammation mainly includes conjunctivitis, keratitis, and uveitis. Taking conjunctivitis as an example, conjunctivitis is a general term for the inflammatory reaction of conjunctival tissue under the action of external and body factors, including bacteria, viruses, chlamydia, Inflammation of the conjunctiva caused by fungi or other external allergens. At present, the drugs for treating ophthalmia mainly include antihistamines, hormone drugs, mast cell stabilizers, decongestants, and inflammatory mediator antagonists. [0003] Hormone drugs, modern science has proved that hormone eye drops have anti-inflammatory, anti-allergic and immunosuppressive effects, and improve metabolism. Long-term use may cause increased intraocular pressure, even nerve damage and vi...

AI Technical Summary

Problems solved by technology

If you use this type of eye drops for a short period of time, there is no big problem, but if you use this type of eye drops repeatedly for a long time, after this type of eye drops, due to the rebound expansion of the bulbar conjunctival blood vessels, the conjunctival hyperemia will be aggravated, and the eyes will look redder.

[0006] Although targeted biological agents have the advantages of good curative effect, especially less toxic and side effects, the biological activity of biological products is unstable, coupled with the high cost, which affects the application of such drugs in the treatment of ocular inflammation

[0007] Eye inflammatory diseases seriously endanger the physical and mental health of the people, and currently there is no therapeutic drug with good curative effect and small side effects. Therefore, it is urgent to develop new drugs for the treatment of inflammatory diseases

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