Preparation for resisting helicobacter pylori and relieving gingivitis and application thereof

An anti-Helicobacter pylori and Helicobacter pylori technology is applied in the field of oral care to achieve the effects of reducing plaque index, reducing bleeding gums and reducing side effects

Inactive Publication Date: 2020-11-13
JIANGSU XUE BAO DAILY CHEM CO
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

These studies all focus on the direct bactericidal and bacteriostatic effects of active ingredients, but the uninhibited or newly entered oral cavity can still colonize the oral cavity, and there are few studies on anti-H. A pro

Method used

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  • Preparation for resisting helicobacter pylori and relieving gingivitis and application thereof
  • Preparation for resisting helicobacter pylori and relieving gingivitis and application thereof
  • Preparation for resisting helicobacter pylori and relieving gingivitis and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0026] 1. Determination of hydrophobicity and self-aggregation ability of lactic acid bacteria strains

[0027] The activated lactic acid bacteria cells were collected by centrifugation, washed with physiological saline, and the concentration of the bacterial suspension was adjusted so that the absorbance value at 600nm wavelength was about 1.000.

[0028] Take 2mL of bacterial suspension, mix with 2mL of xylene, vortex for 20min, let stand at room temperature for 30min, take 1mL of water phase, use normal saline as blank control, measure the absorbance value at 600nm, and calculate the surface hydrophobicity (CSH%) of the strain: H%=[(A 0 -A 1 ) / A 0 ]*100% (where A 0 and A 1 are the absorbance values ​​measured at 600 nm of the aqueous phase before and after mixing with xylene, respectively).

[0029] Take 4mL of bacterial suspension in the same type of test tube, let it stand at room temperature, absorb 1mL of the upper layer solution after 1, 3, and 5 hours to measure ...

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Abstract

A preparation for resisting helicobacter pylori and relieving gingivitis is characterized by being prepared from the following components in percentage by mass: 50 to 80 percent of isoquinoline alkaloid, 1 to 10 percent of lactic acid bacteria (greater than or equal to 1011 cells/g) and 10 to 40 percent of biological polysaccharide. According to the invention, the helicobacter pylori inhibitor andthe anti-helicobacter pylori adhesive are combined for use, so that on one hand, the activity of oral harmful flora such as helicobacter pylori, porphyromonas gingivalis and fusobacterium nucleatum is inhibited through isoquinoline alkaloid, the plaque index is effectively reduced, and symptoms caused by gingivitis such as gingival bleeding and swelling and pain are relieved; on the other hand, adhesion of harmful bacteria is inhibited through direct interaction of lactic acid bacteria, biological polysaccharide and the harmful bacteria such as helicobacter pylori or blocking of available sites in a receptor, and secondary adhesion and field planting of the harmful bacteria such as helicobacter pylori in the oral cavity are prevented. The two synergistically act, so that the side effect of the bacteriostatic agent on beneficial bacteria is reduced.

Description

technical field [0001] The invention belongs to the technical field of oral care, and in particular relates to a preparation for resisting Helicobacter pylori and alleviating gingivitis and its application. Background technique [0002] Helicobacter pylori is a microaerophilic gram-negative bacterium that constitutes a common causative agent of chronic gastritis, peptic ulcer, mucosa-associated lymphoid tissue lymphoma, and gastric cancer, and the stomach is widely believed to be the primary growth site of H. pylori environment. With the deepening of research, Helicobacter pylori has also been detected in human oral dental plaque, saliva, mucosa of the back of the tongue, buccal mucosa, and palate mucosa, and it has been found that periodontal disease and oral mucosal disease are also related to Helicobacter pylori. [0003] Helicobacter pylori is an opportunistic pathogenic bacterium, which is commonly found in the oral cavity of healthy people and gastritis patients, and ...

Claims

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Application Information

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IPC IPC(8): A61K8/99A61K8/49A61K8/73A61Q11/00A61K35/744A61K31/4375A61K31/715A61P31/04A61P1/02
CPCA61K8/49A61K8/73A61K8/99A61K31/4375A61K31/715A61K35/744A61Q11/00A61P1/02A61P31/04A61K2300/00
Inventor 童星徐志良谈红
Owner JIANGSU XUE BAO DAILY CHEM CO
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