Collagen peptide-containing polycaprolactone microsphere filler and preparation method therefor

A technology of collagen peptide and polycaprolactone, which is applied in skin care preparations, microcapsules, capsule delivery, etc., can solve the problems of low skin penetration and low stability, achieve high tissue repair properties, and improve wrinkles , The effect of rapid collagen formation effect

Active Publication Date: 2020-11-03
G2G生物公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, it is a fact that, due to the low in vivo stability of the peptide and the low skin penetration, in cosmetic products and similar products aimed at wrinkle improvement and skin regeneration, the use of biologically active substances is limited by utilizing various derivatives peptide

Method used

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  • Collagen peptide-containing polycaprolactone microsphere filler and preparation method therefor
  • Collagen peptide-containing polycaprolactone microsphere filler and preparation method therefor
  • Collagen peptide-containing polycaprolactone microsphere filler and preparation method therefor

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preparation example Construction

[0031] As a specific example of the preparation method of the collagen peptide-containing polycaprolactone microspheres of the present disclosure, such a preparation method includes the following steps: (a) dissolving polycaprolactone in the first solvent and dissolving the collagen peptide dissolving in a second solvent to prepare respective solutions, and then uniformly mixing the two solutions to prepare a single solution, to prepare a dispersed phase; (b) by mixing said dispersed phase with an aqueous solution (continuous phase) containing a surfactant to prepare an emulsion; (c) by extracting an organic solvent from the dispersed phase in said emulsion prepared in step (b) into the continuous phase and evaporating to form microspheres; and (d) from step (c) The continuous phase recovers the microspheres to prepare polycaprolactone microspheres containing collagen peptides.

[0032] In step (a), the polycaprolactone preferably has an intrinsic viscosity in the range of 0.1...

Embodiment 1

[0052] Example 1: Preparation of Microspheres Encapsulated with Collagen Peptides

[0053] By completely dissolving 9.99 g of biocompatible polymer Purasorb PC 04 (manufacturer: Corbion, Netherlands) and 0.01 g of palmitoyl-KTTKS (manufacturer: Incospharm, Korea) in 39.96 g of dichloromethane (manufacturer: JT Baker , USA) and 2.02 mL of methanol (manufacturer: Sigma Aldrich, USA), and then mix the two solutions to prepare a dispersed phase. A 2 w / v% polyvinyl alcohol aqueous solution (viscosity: 4.8 to 5.8 mPa·s) was used as the continuous phase, and 3200 mL of the continuous phase was supplied to an emulsification device equipped with a 10 μm diameter porous membrane while injecting the prepared dispersion phase to prepare microspheres. The prepared microsphere suspension was placed in a preparation container and stirred at a speed of 150 rpm. The temperature of the membrane emulsification device and the preparation vessel was maintained at 25°C.

[0054]When the inject...

Embodiment 1-1

[0055] Example 1-1: Preparation of microspheres encapsulated with collagen peptides

[0056] By completely dissolving 9.98 g of biocompatible polymer Purasorb PC 04 (manufacturer: Corbion, Netherlands) and 0.02 g of palmitoyl-KTTKS (manufacturer: Incospharm, Korea) in 39.92 g of dichloromethane (manufacturer: JT Baker , USA) and 2.52 mL of methanol (manufacturer: Sigma Aldrich, USA), and then mix the two solutions to prepare a dispersed phase. A 2 w / v% polyvinyl alcohol aqueous solution (viscosity: 4.8 to 5.8 mPa·s) was used as the continuous phase, and 4000 mL of the continuous phase was supplied to an emulsification device equipped with a 10 μm diameter porous membrane while injecting the prepared dispersion phase to prepare microspheres. The prepared microsphere suspension was placed in a preparation container and stirred at a speed of 150 rpm. The temperature of the membrane emulsification device and the preparation vessel was maintained at 25°C.

[0057] When the inj...

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Abstract

The present invention relates to a collagen peptide-containing polycaprolactone microsphere filler and a preparation method therefor. Provided is a plastic surgery filler obtained by loading a collagen peptide into polycaprolactone microspheres, which, when injected into the body, exhibits a rapid collagen formation effect as well as a high tissue restoration property and maintains the effects fora long period of time, thereby showing excellent properties of restoring or expanding the bulk of soft tissues such as cheeks, breasts, nose, lips, and buttocks and reducing wrinkles.

Description

technical field [0001] Cross References to Related Applications [0002] This application claims the benefit of Korean Patent Application No. 10-2018-0003585 filed with the Korean Intellectual Property Office on January 10, 2018, the entire disclosure of which is incorporated herein by reference. [0003] The present disclosure relates to a polycaprolactone microsphere filling and a method for preparing the same, and more particularly, to a polycaprolactone microsphere filling and a method for preparing the same, which not only contains collagen peptides therein Instead, the problem of in vivo stability of collagen peptides is solved, and when administered to a living body, the effect is quickly exhibited after treatment, and the effect can be maintained for a long time. Background technique [0004] A dermal filler is an injectable medical device that injects a material safe for the human body into the dermis of the face to replenish skin tissue, such as improving wrinkle...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/24
CPCA61L27/18A61L27/22A61L27/54A61L27/58A61L2300/25A61L2300/434A61L2300/622A61L2400/06A61L2430/34C08L67/04A61L27/24A61Q19/08A61K8/025A61L27/20A61L27/26A61L2300/452
Inventor 李羲龙薛恩永尹权赫罗勇河
Owner G2G生物公司
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