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Method for extracting cannabidiol from cannabis

A cannabidiol and cannabis technology, applied in the field of medicine, can solve problems such as high loss and low efficiency, and achieve the effects of high crystallization efficiency, improved yield and extended range

Active Publication Date: 2021-04-02
YUNNAN HEMPMON PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The invention provides a preparation method of injection-grade cannabidiol raw materials to solve the problems of high loss and low efficiency in the original process, and fundamentally solve the problem of industrialization of crystallization. At the same time, the CBD finished product can meet the requirements of injection-grade raw materials

Method used

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  • Method for extracting cannabidiol from cannabis
  • Method for extracting cannabidiol from cannabis
  • Method for extracting cannabidiol from cannabis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0103] The preparation of embodiment 1 cannabidiol

[0104] The embodiment part provides that the method of the present invention is used to prepare cannabidiol under different technical parameters. 600 kg, no further description below.

[0105] 1) Pulverize the whole plant of industrial hemp, pass it through an 80-mesh sieve, and obtain medicinal material powder, and its moisture content is measured to be 13.6%;

[0106] 2) The above medicinal material powder was reflux extracted 3 times with 4 times the amount of 30% (V / V) ethanol, each time for 0.5h, to obtain an extract;

[0107] 3) When the above extract (-0.08Mpa, 60°C) was concentrated under reduced pressure to 50°C, the relative density measured was 1.05, and 1 / 10 times the amount of purified water was added to the medicinal material, and concentrated at normal pressure for 1.5h (94°C) to obtain a stream paste;

[0108] 4) Disperse the above liquid ointment with 1 times the amount of purified water, adjust the pH to...

Embodiment 2

[0115] Embodiment 2: the preparation of cannabidiol

[0116] 1) crushing the flowers and leaves of industrial hemp, and passing through a 40-mesh sieve to obtain medicinal material powder, and its moisture content was measured to be 14.2%;

[0117] 2) Ultrasonic-assisted extraction of the above-mentioned medicinal material powder with 5 times the amount of 70% (V / V) ethanol for 0.5 hours each time to obtain an extract;

[0118] 3) Concentrate the above extract (-0.80Mpa, 65°C) under reduced pressure to 50°C, and the measured relative density is 1.35, add 1 / 20 times the amount of purified water of the medicinal material, concentrate at normal pressure for 1h (94°C), and obtain the extract paste;

[0119] 4) Disperse the above extract with 10 times the amount of purified water, adjust the pH to 2.5 with hydrochloric acid (10mol / L), sink in water at a temperature of 20°C for 4 hours, remove impurities, and obtain a water-sinking liquid;

[0120] 5) Centrifuge the above-mentione...

Embodiment 3

[0127] Embodiment 3: the preparation of cannabidiol

[0128] 1) Pulverize the flowers and leaves of industrial hemp, and pass through a 10-mesh sieve to obtain medicinal material powder, the water content of which is measured to be 15.1%.

[0129] 2) The above-mentioned medicinal material powder was soaked and extracted twice with 10 times the amount of 100% (V / V) ethanol, each time for 2.5 hours, to obtain an extract;

[0130] 3) Concentrate the above extract (-0.80Mpa, 65°C) under reduced pressure to 50°C and measure the relative density to 1.2, add 1 / 100 times the amount of purified water of the medicinal material, boil at normal pressure (94°C) for 1.5h, and obtain the extract paste;

[0131] 4) Disperse the above-mentioned extract with 5 times the amount of purified water, adjust the pH to 6.0 with sulfuric acid (18mol / L), sink in water at a temperature of 10°C for 18 hours, remove impurities, and obtain a water-sinking liquid;

[0132] 5) Centrifuge the above-mentioned w...

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Abstract

The present invention relates to the technical field of medicine, and particularly relates to a preparation method for cannabidiol (CBD). The preparation method of the present invention comprises the steps of extraction, decarboxylation, acidic water sedimentation, purification, crystallization, etc. In the present invention, conversion and decarboxylation after extraction can make decarboxylation more complete; acidic water sedimentation greatly improves the yield of cannabidiol (CBD); chromatography and purification by means of a macroporous ion exchange resin achieves a better impurity removal effect; and the dynamic crystallization process by means of the combination of a scraper paddle and a specific menstruum has a higher crystallization efficiency and is more suitable for large-scale production, and the physical characteristics of the obtained crystal are relatively better, facilitating the subsequent formulation development. The CBD raw material prepared by means of the method of the present invention can meet the requirements of injection level, and extends the scope of modern applications.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to a method for extracting cannabidiol from cannabis. Background technique [0002] Industrial hemp (scientific name: Cannabis sativa L.) is a plant of the family Moraceae and the genus Cannabis. The content of tetrahydrocannabinol (THC) in the flowers and leaves during the growth period is less than three per thousand. It does not have the value of extracting THC or directly use it as Drug smoking can be legally carried out in large-scale planting and industrial development and utilization, and its economic and medicinal value are extremely high. [0003] Cannabinoids are a class of active substances contained in cannabis plants, mainly including tetrahydrocannabinol (THC), tetrahydrocannabinoid (THCV), cannabidiol (CBD), cannabigerol (CBG), and cannabidiol (CBG). phenol (CBDV), etc., these five account for more than 90% of cannabinoids. Cannabidiol (CBD, cannabidiol), one of th...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07C39/23C07C37/70C07C37/50
CPCC07C37/004C07C37/50C07C37/685C07C2601/16C07C39/23C07C37/68C07C37/70C07C37/82C07C37/84
Inventor 于朝晖常坦然高伟博柳旭
Owner YUNNAN HEMPMON PHARMA CO LTD
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