Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Preparation method of nano traditional Chinese medicine decoction pieces

A technology of nano-Chinese medicine and decoction pieces, applied in the field of Chinese medicine, can solve the problems of reduced stability of active ingredients, low wall breaking rate, poor dispersion, etc., to reduce the probability of loss of activity, reduce the phenomenon of agglomeration, and avoid local overheating Effect

Inactive Publication Date: 2020-10-30
江西纳弗堂制药有限公司
View PDF2 Cites 4 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, some unstable factors are also prone to occur. For example, the stability of the active ingredients in some traditional Chinese medicines after nanotechnology is reduced, easy to absorb moisture, easy to oxidize, low wall breaking rate, and difficult to store for a long time; in addition, the surface of some Chinese medicines after nanotechnology The charge increases, showing easy aggregation, poor dispersion, and poor compatibility; some traditional Chinese medicines containing mucus cells show great viscosity and poor dispersion after breaking the wall

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] After 500g of fresh notoginseng was pretreated, the fresh notoginseng was sterilized by irradiation for 20 minutes, and the sterilization was γ-radiation sterilization, and the irradiation dose was 5KGy. Wash with deionized water after disinfection, and remove impurities to obtain 475g fresh Panax notoginseng. The processed 475g fresh notoginseng is placed in an extruder, and it is subjected to high-pressure puffing treatment to obtain puffed notoginseng. Add water, ethyl acetate and ethanol (mass ratio 1:1:1) to the puffed Panax notoginseng as a solvent, the amount of solvent added is 1600g, put it into an ultrasonic oscillator, and use an atomizing distributor to add it under ultrasonic conditions An aqueous solution of 10% mass concentration of 3-aminopropyltrimethoxysilane and sodium dodecylsulfonate (mass ratio 2:1), the amount added is 1 / 2 of the solvent, the ultrasonic frequency is 5kHz, and the ultrasonic time is 30min. The speed of the atomizing distributor is...

Embodiment 2

[0035] After pretreatment of 800g of fresh notoginseng cuts, the fresh notoginseng was sterilized by irradiation for 20 minutes, and the sterilization was γ-radiation sterilization, and the irradiation dose was 5KGy. Wash with deionized water after disinfection to remove impurities to obtain 765g of fresh Panax notoginseng. The processed 765g fresh notoginseng is placed in an extruder, and it is subjected to high-pressure puffing treatment to obtain puffed notoginseng. Add water, acetone and 1-methylimidazole (mass ratio 2:1:3) into the puffed Panax notoginseng as a solvent, the amount of solvent added is 1500g, put it into an ultrasonic oscillator, and use atomization distribution under ultrasonic conditions Add 15% mass concentration of 3-aminopropyltrimethoxysilane and sodium dodecylsulfonate (mass ratio 1:1) aqueous solution, the ultrasonic frequency is 8kHz, the ultrasonic time is 12min, and the speed of the atomizing distributor is 75mL / m 2 / min to crush and disperse t...

Embodiment 3

[0038] After pretreatment of 1000g of fresh notoginseng cuts, the fresh notoginseng was sterilized by irradiation for 20 minutes, the sterilization was γ-radiation sterilization, and the irradiation dose was 5KGy. After disinfection, wash with deionized water to remove impurities to obtain 968g fresh notoginseng. Put 968g of processed fresh notoginseng into an extruder, and perform high-pressure puffing treatment on it to obtain puffed notoginseng. Add water and acetic acid (mass ratio 3:1) as a solvent in the puffed Panax notoginseng, the amount of solvent added is 1300g, put it into an ultrasonic oscillator, add 800g of ferroferric oxide magnetic particles, and use atomization under ultrasonic conditions Add the aqueous solution of 5% mass concentration of 3-aminopropyltrimethoxysilane and sodium dodecylsulfonate (mass ratio 1:1) to the dispenser, the ultrasonic frequency is 3kHz, the ultrasonic time is 45min, and the speed of atomization dispenser is 40mL / m 2 / min to crus...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
particle diameteraaaaaaaaaa
particle diameteraaaaaaaaaa
particle diameteraaaaaaaaaa
Login to View More

Abstract

The invention provides a preparation method of a nano traditional Chinese medicine decoction piece, and belongs to the technical field of traditional Chinese medicines, and the preparation method comprises the following steps: 1) high-pressure puffing pretreatment; 2) ultrasonic pre-crushing: adding a solvent into the puffed traditional Chinese medicinal materials, adding a modifier aqueous solution by using an atomization distributor under an ultrasonic condition, and crushing and dispersing the traditional Chinese medicinal materials to obtain a dispersion liquid; 3) high-pressure homogenizing and crushing: carrying out high-pressure homogenizing treatment on the dispersion liquid to obtain a suspension liquid, and carrying out solid-liquid separation treatment to obtain filter residues;and 4) drying: drying the filter residue to obtain the nano traditional Chinese medicine decoction piece. The wall breaking rate of the traditional Chinese medicinal materials is effectively increased, the nanocrystallization rate reaches 99.85% or above, the particle size of the nanocrystallized traditional Chinese medicinal materials ranges from 10 nm to 300 nm, the traditional Chinese medicinal materials are not prone to agglomeration, the obtained nanocrystallized traditional Chinese medicinal materials are high in stability and beneficial to human body absorption, the nanocrystallized traditional Chinese medicinal materials have the quick-acting characteristic, and the bioavailability of the traditional Chinese medicinal materials is fully improved. The preparation method disclosed by the invention has a wide application prospect in the field of traditional Chinese medicine nanocrystallization.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicine, in particular to a preparation method of nanometer traditional Chinese medicine decoction pieces. Background technique [0002] Nanotechnology is the commanding height of scientific and technological development in the 21st century and the leading technology of the new industrial revolution. It has become one of the largest and most competitive research fields in the world. The application of nanotechnology to traditional Chinese medicine decoction pieces is a great innovation for the Chinese medicine industry. Due to the application of nanometer Chinese medicine decoction pieces under the theory of traditional Chinese medicine, there will be no risk of incomplete extraction of nanometer Chinese medicine decoction pieces. It is the best preparation method of all natural ingredients. [0003] The nanonization of animal and plant medicinal materials makes the particles smaller,...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/258A61K36/8984A61K36/068
CPCA61K36/068A61K36/258A61K36/8984A61K2236/11A61K2236/15A61K2236/17
Inventor 宋细忠李小丽习梅兰王德红陈述耀郭志武钱丽梅于喆尹炜郭磊夫
Owner 江西纳弗堂制药有限公司
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com