A kind of anti-hair loss repair composition and application

A composition and anti-hair loss technology, applied in the field of regenerative medicine, can solve the problems of soil damage to hair follicles, obvious pain, cumbersome operation process, etc., and achieve the effects of promoting growth and proliferation, improving anti-hair loss effect, and high purity

Active Publication Date: 2022-04-22
诺赛联合(北京)生物医学科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] 1. Use botulinum toxin: botulinum toxin blocks the transmission of nerve signals, making the scalp tissue in a relaxed state, which is conducive to the growth of hair; but long-term and repeated use will cause the thinning of the scalp tissue and damage the soil of the hair follicle;
[0007] 2. Using hyaluronic acid: Supplementing water and corresponding nutrients can promote hair growth, but repeated use will cause an imbalance of osmotic pressure in the scalp tissue (hypoosmotic);
[0008] 3. Hair transplantation: The operation process is cumbersome and painful, and the cost is relatively high, which cannot solve the problem of survival rate after hair follicle transplantation

Method used

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  • A kind of anti-hair loss repair composition and application
  • A kind of anti-hair loss repair composition and application
  • A kind of anti-hair loss repair composition and application

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0077] A kind of anti-hair loss repairing composition, described anti-hair loss repairing composition comprises:

[0078] will be 5×10 6 Hair follicle progenitor cells were resuspended with 10mL human adipose-derived mesenchymal stem cell lysate, and 0.4mL mesenchymal stem cell factor and 0.4mL platelet-rich fibrin were added;

[0079] Human adipose-derived mesenchymal stem cell lysate is prepared by a method comprising the following steps:

[0080] will be 5×10 7 Human adipose-derived mesenchymal stem cells were digested, dissolved in 10mL of normal saline, frozen in liquid nitrogen, and quickly thawed at 37°C. After 4 freeze-thaw cycles, human adipose-derived mesenchymal stem cells were broken, and the product was obtained.

Embodiment 2

[0082] A kind of anti-hair loss repairing composition, described anti-hair loss repairing composition comprises:

[0083] Will 1×10 6 Hair follicle progenitor cells were resuspended with 10mL human adipose-derived mesenchymal stem cell lysate, and 0.3mL mesenchymal stem cell factor and 0.3mL platelet-rich fibrin were added;

[0084] Human adipose-derived mesenchymal stem cell lysate is prepared by a method comprising the following steps:

[0085] Will 4×10 7 Human adipose-derived mesenchymal stem cells were digested, dissolved in 10mL of normal saline, frozen in liquid nitrogen, and quickly thawed at 37°C. After 4 freeze-thaw cycles, human adipose-derived mesenchymal stem cells were broken, and the product was obtained.

Embodiment 3

[0087] A kind of anti-hair loss repairing composition, described anti-hair loss repairing composition comprises:

[0088] Will 1×10 7 Hair follicle progenitor cells were resuspended with 10mL human adipose-derived mesenchymal stem cell lysate, and 0.5mL mesenchymal stem cell factor and 0.5mL platelet-rich fibrin were added;

[0089] Human adipose-derived mesenchymal stem cell lysate is prepared by a method comprising the following steps:

[0090] will be 6×10 7 Human adipose-derived mesenchymal stem cells were digested, dissolved in 10mL of normal saline, and crushed by a cell disruptor.

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Abstract

The embodiments of the present invention relate to regenerative medicine, in particular to an anti-hair loss repairing composition and its application. The anti-hair loss repair composition provided by the embodiments of the present invention includes: hair follicle progenitor cells, mesenchymal stem cell factors, mesenchymal stem cell lysate and platelet-rich fibrin; wherein, every 10mL mesenchymal stem cell lysate is mixed with (1- 10)×10 6 Hair follicle progenitor cells, 0.2-0.6mL mesenchymal stem cell factor, 0.2-0.6mL platelet-rich fibrin mixed; mesenchymal stem cell lysate was prepared by a method comprising the following steps: (1-10)×10 7 The mesenchymal stem cells were digested, dissolved in 10 mL of normal saline, and obtained by freeze-thawing or mechanical disruption. The anti-hair loss repairing composition provided by the invention can fundamentally solve the hair follicle problem, restore the function of the hair follicle, and has good effect in treating hair loss.

Description

technical field [0001] The invention relates to regenerative medicine, in particular to an anti-hair loss repairing composition and its application. Background technique [0002] According to the World Health Organization, 1 out of every 5 adult males suffers from hair loss, while 1 out of 20 women suffers from hair loss. [0003] The problem of hair loss in our country tends to be younger. Now the post-80s and post-90s have gradually become the main force of hair loss. The proportion of hair loss in this group has exceeded 35%. Baldness caused by overwork and obesity has troubled many people. [0004] According to the "China Hair Loss Population Survey", there are about 200 million hair loss people in my country, and 90% of them will not get better if they die. The number of men with hair loss is about 130 million, and the male hair loss rate in my country is nearly 20%. Among them, men aged 20-40 are the main force of hair loss. [0005] There are three main methods on ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K35/36A61P17/14C12N5/071C12N5/0775A61K35/28A61K35/16
CPCA61K35/36A61K35/28A61K35/16A61P17/14C12N5/0628C12N2509/00C12N2509/10A61K2300/00
Inventor 亓爱杰李少波马宏磊亓爱磊
Owner 诺赛联合(北京)生物医学科技有限公司
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