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Application preparation and indications thereof

A technology of remdesivir and preparations, applied in the field of medicine

Inactive Publication Date: 2020-10-27
BEIJING WANQUAN SUNSHINE MEDICAL TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although 20-C-methyl-ATP is not incorporated, ara-ATP acts as a non-obligate chain terminator and prevents nucleotide incorporation at position i

Method used

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  • Application preparation and indications thereof
  • Application preparation and indications thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0013] Remdesivir tablet preparation process: Reed is micronized to a particle size of less than 100 microns, sorbitol monolaurate and mannitol are added as auxiliary materials, and magnesium stearate is added after wet granulation and drying, and compressed to obtain tablet cores. Coating to get the final product.

Embodiment 2

[0015] Remdesivir liquid preparation process: Mix the co-solvents ethanol, propylene glycol and glycerin evenly, add Remdesivir and stir until completely dissolved, and adjust the pH to 4-5 with pH adjuster hydrochloric acid or sodium hydroxide to obtain the final product.

Embodiment 3

[0017] Preparation process of Remdesivir freeze-dried powder injection: Dissolve β-cyclodextrin in water for injection, add Remdesivir and stir for no less than 5 hours, adjust the pH value to 4.0 with hydrochloric acid or sodium hydroxide, and pack in freeze-dried in vials.

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PUM

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Abstract

The invention discloses an application of remdesivir in preparation of a medicine for treating novel coronavirus (2019-nCoV). A remdesivir preparation can effectively improve respiratory distress, cough, expectoration, fever and other systemic symptoms of patients infected with the novel coronavirus (2019-nCoV), delay disease progression and improve the life quality of the patients, and has wide application value. The preparation which is relatively good in product stability and is used for preventing and treating the novel coronavirus is obtained through drug research and determination.

Description

technical field [0001] The invention relates to Remdesivir and a preparation thereof, in particular to a preparation for preventing and treating a novel coronavirus (2019-nCoV), a preparation method and indications thereof, and belongs to the field of medical technology. Background technique [0002] Remdesivir is a broad-spectrum antiviral drug developed by Gilead Sciences. Remdesivir, as a nucleoside RNA-dependent RNA polymerase (RdRp) competitive inhibitor, its triphosphate nucleotide product Remdesivir-TP can compete with RdRp for substrate ATP, so it can interfere with viral vRNA synthesis. RdRp is an RNA polymerase widely distributed in positive- and double-stranded RNA viruses. [0003] Remdesivir (GS-5734) is a 10-cyano-substituted adenosine nucleotide analog prodrug with broad-spectrum antiviral activity against a variety of RNA viruses. The compound is currently in clinical development for the treatment of Ebola virus disease (EVD). Although antiviral effects ha...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/675A61K9/19A61K47/69A61P31/14A61P11/00
CPCA61K9/19A61K31/675A61K47/6951A61P11/00A61P31/14
Inventor 郭夏宋雪梅邢沙沙
Owner BEIJING WANQUAN SUNSHINE MEDICAL TECH CO LTD
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