Oral bone regeneration and repair system and preparation method thereof

Abstract

The invention provides an oral bone regeneration and repair system and a preparation method thereof, and belongs to the technical field of oral implantation. The preparation method comprises the following steps: acquiring three-dimensional morphological data of a bone defect area of an oral cavity to be repaired; separately establishing a barrier membrane three-dimensional model and a bone scaffold three-dimensional model according to the three-dimensional morphological data of the bone defect area; according to the barrier membrane three-dimensional model, forming a drug-loaded barrier membrane through printing, wherein the drug-loaded barrier membrane comprises a first arc-shaped surface and a second arc-shaped surface which are oppositely arranged in the thickness direction of the drug-loaded barrier membrane, and the first arc-shaped surface corresponds to the bone defect area of the oral cavity to be repaired; and according to the bone scaffold three-dimensional model, printing onthe first arc-shaped surface of the drug-loaded barrier membrane to form a drug-loaded porous bone scaffold so as to obtain the oral bone regeneration and repair system. According to the preparationmethod, the drug-loaded barrier membrane and the drug-loaded porous bone scaffold can be formed in batches by adopting a 3D printing technology, and the two-step forming method effectively avoids thermal decomposition of drugs with soft tissue healing promoting and antibacterial functions in the drug-loaded barrier membrane in the preparation process.

Description

technical field [0001] The invention belongs to the technical field of oral implantation, and in particular relates to a preparation method of an oral bone regeneration repair system and an oral bone regeneration repair system. Background technique [0002] Craniomaxillofacial bone is an important part of oral bone tissue. It not only serves as bony support, but also serves as the structural basis for mastication, swallowing and language. Various pathogenic factors such as tumors, trauma, osteoradionecrosis, osteomyelitis, periodontitis or congenital diseases can lead to bone defects and loss, and its incidence rate accounts for the first place in oral diseases. Severe craniomaxillofacial bone defects will further cause facial deformities and dysfunction, and at the same time increase the difficulty of subsequent oral restorative treatment, causing great physical and psychological pain to patients. Cranio-maxillofacial bone defect repair and reconstruction surgery is very d...

AI Technical Summary

Problems solved by technology

However, the traditional absorbable collagen membrane or titanium membrane lacks certain anti-infection ability and the function of promoting tissue healing. Insufficient soft tissue and bacterial infection in the defect area often occur after bone augmentation surgery.

[0004] Therefore, in view of the problems of the above-mentioned barrier membranes, as well as the different forms of oral bone resorption damage, the disadvantages of long operation time for bone powder implantation, not easy to accumulate, complicated operation, and easy to cause infection, it is necessary to develop a new oral bone regeneration method. The repair system, which includes a barrier film that can meet the above requirements, and can achieve personalized customization, resist local bacterial growth in the oral cavity, quickly attract soft tissue healing, and promote in situ regeneration of bone tissue in bone defect areas

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