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Echinacea extract and preparation method thereof

A technology of Echinacea purpurea extract and Echinacea purpurea, applied in the field of medicine, can solve the problems of unfavorable development of new products, reduce the content of cichoric acid, etc., and achieve the effects of improving the low content of cichoric acid, low cost, and increasing benefits

Inactive Publication Date: 2020-09-29
JILIN HONGJIU BIO TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] One of the effective active ingredients of Echinacea purpurea extract is polyphenolic substances represented by cichoric acid. However, there is a polyphenol oxidase in Echinacea purpurea plants that can catalyze and decompose the active ingredients of polyphenols. The content of cichoric acid is gradually reduced in the process of extracting Echinacea purpurea, which is not conducive to the development of new products

Method used

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  • Echinacea extract and preparation method thereof
  • Echinacea extract and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0018] A kind of preparation method of Echinacea purpurea extract

[0019] Take 600kg of fresh Echinacea purpurea raw materials, cut into 10cm sections; add 90°C hot water into the countercurrent extractor, then put the cut Echinacea purpurea into the countercurrent extraction tank, and carry out continuous extraction for 90min; adjust the pH value of the extract to 6.2 The extract is filtered and poured into a high-level storage tank; the extract is passed through a pre-treated D941 macroporous weak base anion exchange resin column (330kg resin is installed in a single resin column), and the column liquid is collected, and the flow rate is controlled at 4BV / h of the resin volume; Concentrate the column liquid under reduced pressure to a relative density of 1.12 (60°C), weigh it, add 2.5 times the weight of 95% ethanol, stir for 10 minutes, and precipitate with alcohol. Take the supernatant, filter it, concentrate under reduced pressure, and spray dry to obtain Echinacea purpur...

Embodiment 2

[0021] A kind of preparation method of Echinacea purpurea extract

[0022] Take 600kg of fresh Echinacea purpurea raw materials, cut into 15cm sections; add 92°C hot water into the countercurrent extractor, then put the cut Echinacea purpurea into the countercurrent extraction tank, and carry out continuous extraction for 90min; adjust the pH value of the extract to 5.2 ; The extract is filtered and poured into the high-level storage tank; the extract passes through the pre-treated D941 macroporous weak base anion exchange resin column (330kg resin is installed in a single resin column), and the column liquid is collected, and the flow rate is controlled at 3.5BV / h of the resin volume Concentrate the column liquid under reduced pressure to a relative density of 1.14 (60° C.), weigh, add 2.7 times the weight of 95% ethanol, stir for 10 minutes, and precipitate with alcohol. Take the supernatant, filter it, concentrate under reduced pressure, and spray dry to obtain Echinacea pu...

Embodiment 3

[0024] A kind of preparation method of Echinacea purpurea extract

[0025] Take 600kg of fresh Echinacea purpurea raw materials and cut them into 10cm sections; add hot water at 94°C to the countercurrent extractor, then put the cut Echinacea purpurea into the countercurrent extraction tank, and carry out continuous extraction for 75min; adjust the pH value of the extract to 4.5 The extract is filtered and poured into a high-level storage tank; the extract is passed through a pre-treated D941 macroporous weak base anion exchange resin column (330kg resin in a single column), and the column liquid is collected, and the flow rate is controlled at 2.5BV / h of the resin volume; Concentrate the column liquid under reduced pressure to a relative density of 1.15 (60°C), weigh it, add 2.7 times the weight of 95% ethanol, stir for 15 minutes, and precipitate with alcohol. Take the supernatant, filter it, concentrate under reduced pressure, and spray dry to obtain Echinacea purpurea Extr...

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Abstract

The invention relates to an echinacea extract and a preparation method thereof, and belongs to the technical field of medicine. The fresh echinacea is harvested from mid-August to the end of Septembereach year and cut into sections of 5-15 cm, hot water at 90-98 DEG C is firstly added to a continuous countercurrent extractor, and then the cut fresh echinacea is put for enzyme inactivation; the pHvalue is adjusted to 4.2-6.2, and spraying extraction is performed for 60-90min to obtain an extraction solution; then the extraction solution passes through D941 macroporous weak base anion exchangeresin (each resin column is loaded with 330-780 kg of resin), and a column liquid is collected; the column liquid is concentrated under reduced pressure to a relative density of 1.12-1.18, ethanol with the volume of 2.5-3.2 times is added to obtain an alcohol precipitate, and then concentration under reduced pressure is continued to recover the ethanol to obtain an extract; and the extract is subjected to spray drying to obtain the echinacea extract. By use of the extraction method of the present invention, technologies such as raw material harvesting, continuous extraction, pH adjustment andresin purification are completed in a relatively short time, and the cichoric acid content is increased to 4%-12%. Large-scale production reduces the cost of the echinacea extract and is beneficial to marketization.

Description

technical field [0001] The invention belongs to the technical field of medicine and relates to a traditional Chinese medicine extract, in particular to a method for preparing an extract of Echinacea purpurea and the extract of Echinacea purpurea prepared by the method. Background technique [0002] The extract of Echinacea purpurea is derived from the plant of Echinacea genus, and the extract of Echinacea purpurea prepared through extraction and other processes can be used as an immune enhancer and regulator, which can significantly improve the immune regulation level of the body, and is mainly used to treat colds (upper respiratory tract infections) Symptoms of a bacterial infection. In 1989, it ranked 131 among the 2000 most commonly used prescriptions in Germany. In 1982, there were as many as 300 kinds of single and compound preparations of Echinacea purpurea, and many dosage forms have been widely used clinically, such as treating acute and chronic respiratory tract in...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/28A61P37/02
CPCA61K36/28A61K2236/331A61K2236/51A61K2236/53A61K2236/55A61P37/02
Inventor 詹晓峰冯涛周岩
Owner JILIN HONGJIU BIO TECH
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