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BCN two-dimensional nano sheet enhanced biological ceramic scaffold as well as preparation method and application thereof

A two-dimensional nanoscale and biological scaffolding technology, applied in nanocarbon, pharmaceutical formulations, additive processing, etc., can solve the problems of difficult to completely remove tumor lesions, unable to achieve bone defect repair, affecting the recovery speed of patients, etc., and achieve a good repair effect. , good photothermal performance and biological activity, the effect of eliminating residual tumor

Active Publication Date: 2020-09-25
SHANGHAI NINTH PEOPLES HOSPITAL AFFILIATED TO SHANGHAI JIAO TONG UNIV SCHOOL OF MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Clinically, limb salvage treatment for patients with bone tumors makes it difficult to completely remove tumor lesions, and the current radiotherapy and chemotherapy will cause great toxic and side effects to patients. Therefore, how to safely prevent the recurrence of osteosarcoma after surgery has become a clinical issue. challenging questions
In addition, in order to repair the bone defect caused by the resection of the lesion, bone graft materials are often used in clinical practice, including autogenous bone inactivation and replantation, artificial joint replacement and other methods to repair the damage. However, implant materials without biological activity will affect the recovery speed of patients
Photothermal therapy has shown great advantages as a safe and effective new therapy to kill tumors at specific sites. However, most of the currently commonly used photothermal agents lack biological activity and cannot repair bone defects.

Method used

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  • BCN two-dimensional nano sheet enhanced biological ceramic scaffold as well as preparation method and application thereof
  • BCN two-dimensional nano sheet enhanced biological ceramic scaffold as well as preparation method and application thereof
  • BCN two-dimensional nano sheet enhanced biological ceramic scaffold as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] (1) 5g boric acid is dissolved in 80°C deionized water, and then 0.5g gelatin is added and stirred until it is evaporated and crystallized. The crystalline product was annealed in nitrogen at 900°C for 1 hour to obtain a crude material, which was then refluxed for 2 hours and dialyzed for 3 days to finally obtain BCN nanosheet powder;

[0039] (2) The BCN powder is ultrasonically dispersed in deionized water to obtain a BCN solution with a concentration of 0.25 mg / ml;

[0040] (3) 5.0g of AKT ceramic powder, fully mixed with 0.3g of sodium alginate (SA) and 3g of PF127 (20wt%), three-dimensionally print the AKT body;

[0041] (4) The AKT body is calcined at 1350°C for 3 hours to obtain the AKT bracket;

[0042] (5) Soak the AKT scaffold in a 0.25mg / ml BCN solution for 3 times, 10 minutes each time, and dry it in an oven at 120°C after each soaking; obtain a BCN two-dimensional nanosheet-enhanced integrated biological scaffold, referred to as 2.5BCN@AKT bracket;

[0043] (6) Cha...

Embodiment 2

[0045] (1) 5g boric acid is dissolved in 80°C deionized water, and then 0.5g gelatin is added and stirred until it is evaporated and crystallized. The crystalline product was annealed in nitrogen at 900°C for 1 hour to obtain a crude material, which was then refluxed for 2 hours and dialyzed for 3 days to finally obtain BCN nanosheet powder;

[0046] (2) The BCN powder is ultrasonically dispersed in deionized water to obtain a BCN solution with a concentration of 0.50 mg / ml;

[0047] (3) 5.0g of AKT ceramic powder, fully mixed with 0.3g of sodium alginate (SA) and 3g of PF127 (20wt%), three-dimensionally print the AKT body;

[0048] (4) The AKT body is calcined at 1350°C for 3 hours to obtain the AKT bracket;

[0049] (5) Soak the AKT scaffold in a 0.50mg / ml BCN solution for 3 times, 10 minutes each time, and dry it in an oven at 120°C after each soaking; obtain a BCN two-dimensional nanosheet reinforced integrated biological scaffold, referred to as 5BCN@AKT bracket;

[0050] (6) Cha...

Embodiment 3

[0052] (1) 5g boric acid is dissolved in 80°C deionized water, and then 0.5g gelatin is added and stirred until it is evaporated and crystallized. The crystalline product was annealed in nitrogen at 900°C for 1 hour to obtain a crude material, which was then refluxed for 2 hours and dialyzed for 3 days to finally obtain BCN nanosheet powder;

[0053] (2) The BCN powder is ultrasonically dispersed in deionized water to obtain a BCN solution with a concentration of 0.75 mg / ml;

[0054] (3) 5.0g of AKT ceramic powder, fully mixed with 0.3g of sodium alginate (SA) and 3g of PF127 (20wt%), three-dimensionally print the AKT body;

[0055] (4) The AKT body is calcined at 1350°C for 3 hours to obtain the AKT bracket;

[0056] (5) Soak the AKT scaffold in a 0.75mg / ml BCN solution for 3 times, 10 minutes each time, and dry it in an oven at 120°C after each soaking; obtain a BCN two-dimensional nanosheet reinforced integrated biological scaffold, referred to as 7.5BCN@AKT bracket;

[0057] (6) C...

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Abstract

The invention discloses a BCN two-dimensional nano sheet enhanced integrated biological scaffold as well as a preparation method and application thereof. The integrated biological scaffold comprises aBCN two-dimensional nano sheet and a biological ceramic scaffold, wherein the BCN two-dimensional nano sheet is uniformly coated on the surface of the biological ceramic scaffold to form the integrated biological scaffold. The preparation method comprises the following steps: preparing a B / N co-doped BCN two-dimensional nano sheet; preparing an akermanite substrate bracket by adopting a three-dimensional printing technology; soaking the akermanite substrate bracket in a BCN two-dimensional nano sheet solution, drying the akermanite substrate bracket after soaking, and adjusting the soaking times and the concentration of the BCN two-dimensional nano sheet solution to enable the coating thickness of BCN to be 1-5 [mu]m to obtain the BCN two-dimensional nano sheet enhanced integrated biological scaffold. The BCN two-dimensional nano sheet is used as a novel two-dimensional material and is applied to the fields of tumor treatment and bone defect repair for the first time. The provided integrated biological scaffold can play a dual role in eliminating residual tumors and repairing bone defects after tumor operation.

Description

Technical field [0001] The invention belongs to the technical field of biomaterials, and specifically relates to a BCN two-dimensional nanosheet reinforced bioceramic stent and a preparation method and application thereof. Background technique [0002] Osteosarcoma is one of the common malignant bone tumors. Surgical resection and combined chemotherapy / radiotherapy are still the main treatment methods. Clinically, the limb salvage treatment for bone tumor patients makes it difficult to completely remove the tumor lesions. The currently used radiotherapy and chemotherapy will cause great toxic side effects on the patient. Therefore, how to safely prevent the recurrence of postoperative osteosarcoma has become a clinical issue. Challenging questions. In addition, in order to repair the bone defect caused by the resection of the lesion, bone graft materials including autologous bone inactivated replantation and artificial joint replacement are often used clinically to repair the da...

Claims

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Application Information

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IPC IPC(8): C04B35/22C04B35/622B33Y10/00B33Y70/10C04B41/85C01B32/15A61L27/50A61L27/54A61L27/30A61L27/02
CPCC04B35/22C04B35/622B33Y10/00B33Y70/10C04B41/85C04B41/5001C04B41/009C01B32/15A61L27/50A61L27/54A61L27/303A61L27/306A61L27/025A61L2430/02A61L2400/12A61L2300/416A61L2300/412A61L2300/606C04B41/4535
Inventor 王旭东赵灿灿林开利
Owner SHANGHAI NINTH PEOPLES HOSPITAL AFFILIATED TO SHANGHAI JIAO TONG UNIV SCHOOL OF MEDICINE
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