Lactobacillus plantarum SD-H9, probiotic microbial agent of Lactobacillus plantarum SD-H9, and application of Lactobacillus plantarum SD-H9

Abstract

The invention proposes Lactobacillus plantarum SD-H9, and a probiotic microbial agent of the Lactobacillus plantarum SD-H9, and an application of the Lactobacillus plantarum SD-H9. The Lactobacillus plantarum SD-H9 of the invention is preserved in the China General Microbiological Culture Collection Center (CGMCC), and a preservation number is CGMCC NO.16649. The probiotic microbial agent providedby the invention can effectively alleviate nasal symptoms of rats with allergic rhinitis, reduces the content of histamine, OVA-specific IgE and IL-4 in the serum of the rhinitis rats, improves the content of IFN-gamma in the serum of the rats, helps to alleviate allergic reactions, induces correct immune responses, thereby changes the bias of Th2 cells that promote allergic reactions, plays a role in the treatment of allergic rhinitis by regulating the immune function of a host, and can effectively improve the symptoms of rhinitis.

Description

technical field [0001] The invention belongs to the technical field of microbes, and in particular relates to a plantarum lactobacillus SD-H9, its probiotic agent and its application. Background technique [0002] Allergic rhinitis is a common and frequently occurring disease of the respiratory system. Its main clinical manifestations are nasal congestion, nasal itching, paroxysmal sneezing, a large amount of watery nasal discharge, and olfactory dysfunction. In addition, it may also cause or be complicated by sinusitis , nasal polyps, pharyngitis, otitis media, trachea and bronchitis, chest pain, chest tightness, asthma and allergic conjunctivitis and other diseases seriously affect the quality of life of patients, endanger people's health and easily induce various diseases. Allergic rhinitis is mainly caused by the inhalation of allergens by patients and the release of inflammatory mediators, leading to inflammation of the nasal mucosa. The number of people suffering from...

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Problems solved by technology

[0003] At present, rhinitis is mainly treated by nasal cleaning drugs prepared from bactericidal drugs or aspirin, ibuprofen, chlorpheniramine and other antibiotic drugs. Neglecting the use of antibiotics to clean or sterilize the nasal cavity will increase the side effects and drug hazards to the human body, and at the same time, the nasal mucosa is also prone to adverse problems such as lesions after long-term strong stimulation by drugs

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