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Lactobacillus plantarum sd-h9, its probiotics and its application

A technology of Lactobacillus plantarum and probiotics, which is applied in the field of microorganisms, can solve the problems of nasal mucosa prone to lesions, human side effects and drug hazards, and achieve the effects of improving nasal allergy symptoms, changing cell bias, and increasing IFN-γ content

Active Publication Date: 2022-08-05
深圳华大基因农业控股有限公司
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  • Abstract
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Problems solved by technology

[0003] At present, rhinitis is mainly treated by nasal cleaning drugs prepared from bactericidal drugs or aspirin, ibuprofen, chlorpheniramine and other antibiotic drugs. Neglecting the use of antibiotics to clean or sterilize the nasal cavity will increase the side effects and drug hazards to the human body, and at the same time, the nasal mucosa is also prone to adverse problems such as lesions after long-term strong stimulation by drugs

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  • Lactobacillus plantarum sd-h9, its probiotics and its application
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  • Lactobacillus plantarum sd-h9, its probiotics and its application

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[0017] In order to make the objectives, technical solutions and advantages of the present invention clearer, the present invention will be further described in detail below with reference to the embodiments and accompanying drawings. It should be understood that the specific embodiments described herein are only used to explain the present invention, but not to limit the present invention.

[0018] Isolation and identification of Lactobacillus plantarum SD-H9

[0019] Take 10 g of healthy human intestinal excrement for 10-fold gradient dilution with sterile normal saline, and dilute the sample to 10 6 After doubling, it was coated on MRS agar medium, cultivated for 24h, observed the colony morphology, picked a single colony suspected of lactic acid bacteria from it, and streaked and separated it on a new MRS agar medium, and carried out streak separation and purification again after culturing for 24h. A sterile toothpick was used to pick several single colonies from the med...

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Abstract

The present invention provides a Lactobacillus plantarum SD-H9, a probiotic bacterial agent thereof and applications thereof. The Lactobacillus plantarum SD-H9 of the present invention is preserved in China General Microorganism Culture Collection and Management Center (CGMCC), and the preservation number is CGMCC NO.16649. Using the probiotics provided by the invention can effectively relieve the nasal symptoms of allergic rhinitis rats, reduce the content of histamine, OVA-specific IgE and IL-4 in the serum of the rhinitis rats, and improve the IFN-γ content in the serum of the rats, It helps to alleviate allergic reactions and induce correct immune responses, thereby changing the bias of Th2 cells that promote allergic reactions, and exerting a therapeutic effect on allergic rhinitis by regulating the immune function of the host, which can effectively improve the symptoms of rhinitis.

Description

technical field [0001] The invention belongs to the technical field of microorganisms, and in particular relates to a Lactobacillus plantarum SD-H9, a probiotic bacterial agent thereof and applications thereof. Background technique [0002] Allergic rhinitis is a common and frequent disease of the respiratory system. Its main clinical manifestations are nasal congestion, nasal itching, paroxysmal sneezing, a lot of watery nasal discharge and olfactory dysfunction. In addition, it may also lead to or be complicated by sinusitis. , nasal polyps, pharyngitis, otitis media, trachea and bronchitis, chest pain, chest tightness, asthma and allergic conjunctivitis and other diseases, seriously affect the quality of life of patients, endanger people's health and easily induce a variety of diseases. Allergic rhinitis is mainly caused by the inhalation of allergens and the release of inflammatory mediators, leading to inflammation of the nasal mucosa. The number of people suffering fr...

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C12N1/20A61K35/747A61P11/02A61P37/08C12R1/25
CPCC12N1/20A61K35/747A61P11/02A61P37/08C12R2001/25C12N1/205
Inventor 王明明蒋蕊赵山岑刘松玲代晓霜宋颀任军丽
Owner 深圳华大基因农业控股有限公司
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