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Mouthwash for inhibiting activity of dental plaque mycoderm

A technology for mouthwash and plaque bacteria, applied in the direction of inorganic active ingredients, organic active ingredients, dentistry, etc., can solve the problem of unsatisfactory deep cleaning effect of the oral environment, difficulty in ensuring the uniformity and stability of the solution, and untargeted oral flora Strong and other problems, to achieve the effect of improving solution stability, appropriate fineness, and rich taste

Active Publication Date: 2020-08-18
浙江敬紫堂生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But the mouthwash in the prior art lacks the special formula for dental plaque characteristic
For example, the patent No. is CN201810118780.8, a kind of mouthwash containing rare saponins of Panax notoginseng and its preparation method. Its components have limited effect on the inhibition of dental plaque bacteria that form better biofilms, and have little effect on the deep cleaning of the oral environment. Unsatisfactory; Another example is a kind of mouthwash containing acidic bactericide and its preparation method whose patent No. is CN201910046403.2. The sterilization method is relatively simple, and it is difficult to achieve the purpose of long-term antibacterial for the oral cavity with complex flora; another example is a mouthwash powder containing sodium azulenesulfonate and its preparation method with the patent number CN201710120533.7. Its sterilizing method is conventional, and its pertinence to the oral flora is not strong. At the same time, it uses powder, which makes it difficult to ensure the uniformity and stability of the solution during preparation, and the bactericidal effect will also be affected.

Method used

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  • Mouthwash for inhibiting activity of dental plaque mycoderm
  • Mouthwash for inhibiting activity of dental plaque mycoderm
  • Mouthwash for inhibiting activity of dental plaque mycoderm

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] A mouthwash for inhibiting plaque activity, comprising the following raw materials: 60 parts of propolis alcohol extract, 10 parts of beta-cyclodextrin, 40 parts of tea polyphenols, 40 parts of mint essence, 3 parts of nano-silver particles 5 parts of gold nanorod adsorbate, 20 parts of vitamin D, 20 parts of malic acid, 10 parts of tartaric acid, 10 parts of sulfated polysaccharide, 5 parts of gelatin, 5 parts of surfactant, 5 parts of chlorhexidine, flavescens 5 parts of fine powder and 200 parts of purified water. The preparation method of the propolis alcohol extract is as follows: mix the propolis and the alcohol solution according to the mass ratio of 1:5, heat to 50° C., stir for 20 minutes, and collect the supernatant for later use; add alcohol solution 3 times its mass to the residue , heated to 60°C, stirred for 20min, and the supernatant was taken; the two supernatants were combined, dried at 0.1 standard atmospheric pressure and 45°C to obtain the propolis e...

Embodiment 2

[0025]A mouthwash for inhibiting plaque activity, comprising the following raw materials: 70 parts of propolis alcohol extract, 20 parts of beta-cyclodextrin, 50 parts of tea polyphenols, 50 parts of mint essence, and 5 parts of nano-silver particles 8 parts of gold nanorod adsorbate, 28 parts of vitamin D, 26 parts of malic acid, 20 parts of tartaric acid, 18 parts of sulfated polysaccharide, 8 parts of gelatin, 10 parts of surfactant, 10 parts of chlorhexidine, flavescens 15 parts of fine powder and 350 parts of purified water. The preparation method of the propolis alcohol extract is as follows: mix propolis and alcohol solution according to the mass ratio of 1:5, heat to 55° C., stir for 25 minutes, collect the supernatant for later use; add alcohol solution 5 times its mass to the residue , heated to 65°C, stirred for 30min, and the supernatant was taken; the two supernatants were combined, and dried at 0.3 standard atmospheric pressure and 48°C to obtain the propolis eth...

Embodiment 3

[0031] A mouthwash for inhibiting plaque activity, comprising the following raw materials: 67 parts of propolis alcohol extract, 17 parts of beta-cyclodextrin, 44 parts of tea polyphenols, 46 parts of mint essence, and 4 parts of nano-silver particles 6 parts of gold nanorod adsorbate, 26 parts of vitamin D, 23 parts of malic acid, 15 parts of tartaric acid, 13 parts of polysaccharide sulfate, 7 parts of gelatin, 8 parts of surfactant, 8 parts of chlorhexidine, flavescens 12 parts of fine powder and 280 parts of purified water. The preparation method of the propolis alcohol extract is as follows: mix propolis and alcohol solution according to the mass ratio of 1:5, heat to 53° C., stir for 23 minutes, and collect the supernatant for later use; add alcohol solution 5 times its mass to the residue , heated to 60°C, stirred for 30min, and took the supernatant; combined the two supernatants, dried at 0.1 standard atmospheric pressure and 48°C to obtain the propolis ethanol extract...

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Abstract

The invention relates to the technical field of medical formulas, in particular to mouthwash for inhibiting the activity of dental plaque mycoderm. The mouthwash is prepared from the following raw materials in parts by weight: propolis alcohol extract, beta-cyclodextrin, tea polyphenol, peppermint essence, nano-silver particles, gold nano-rod adsorbate, vitamin D, malic acid, tartaric acid, sulfated polysaccharide, gelatin, a surfactant, dichlorobenzene biguanide hexane, radix sophorae flavescentis superfine powder and purified water. Aiming at the fact that the streptococcus mutans surface protein sample with the largest number in the dental plaque participates in adhesion to form a biological membrane, by interfering synthesis of streptococcus mutans cell membrane functional protein, permeation of medicine to the biological membrane is promoted, the drug resistance of thalli to dichlorobenzene biguanide hexane is reduced, and the activity of the dental plaque biological membrane is remarkably reduced.

Description

technical field [0001] The invention relates to the technical field of pharmaceutical formulations, in particular to a mouthwash for inhibiting plaque activity. Background technique [0002] Mouthwash is an indispensable oral hygiene product in people's daily life, and its basic function is to clean teeth, freshen breath, and reach the purpose of keeping oral cavity clean. In recent years, due to the increasing awareness of consumer health care, more requirements have been put forward for mouthwashes. In addition to cleaning teeth, some functions have been added to assist in the prevention of oral diseases and have a nursing and health care effect on the oral cavity. Therefore, mouthwashes at home and abroad have Various functional products have become the mainstream of the market, and because the active ingredients of traditional Chinese medicine plants have advantages that cannot be compared with western medicines such as naturalness and safety, functional mouthwashes with...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/98A61K8/9789A61K8/73A61K8/65A61K8/60A61K8/55A61K8/43A61K8/365A61K8/19A61Q11/00A61K36/718A61P1/02A61P31/02A61P31/04A61K33/242A61K33/38A61K31/155
CPCA61K8/988A61K8/9789A61K8/738A61K8/73A61K8/65A61K8/60A61K8/553A61K8/43A61K8/365A61K8/19A61Q11/00A61K31/155A61K36/489A61K33/242A61K33/38A61K36/718A61K36/532A61K36/21A61K36/282A61P1/02A61P31/02A61P31/04A61K2800/413A61K2800/596A61K2300/00Y02A50/30
Inventor 童建华李正亮
Owner 浙江敬紫堂生物科技有限公司
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