Lipid in excrement for detecting active pulmonary tuberculosis and detection system thereof
A technology of active pulmonary tuberculosis and detection system, which is applied in the field of biomarkers, can solve the problems of insufficient resolution and low sensitivity, and achieve the effects of good repeatability, small injection volume and simple sample processing
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Embodiment 1
[0040] A detection system for detecting active pulmonary tuberculosis, comprising parameter acquisition equipment and a data processing device with the following data processing functions:
[0041] Analyze the results of the test patient's feces detected by LC-MS, and output the conclusion according to the following standard: if one or more of the 13 differential metabolites in the test patient's feces, their relative expression levels are all >2X Un group average value (i.e. 2 times the mean value of the uninfected Mtb healthy group) and the relative expression levels are >2X the mean value of the LTBI group (i.e. 2 times the mean value of the uninfected Mtb healthy group), then the patient to be tested is or is a candidate for activity tuberculosis patients; the above 13 differential metabolites include 1-Naphthylamine 1-naphthylamine, Bilirubin bilirubin, delta-Hydroxylysineδhydroxylysine, Docosanamide, Dodemorph, Himbacine, Indolelactic acid, N-Cyclohexylformamide N-cycloh...
Embodiment 2
[0048] Example 2 A method for judging active pulmonary tuberculosis based on feces LC-MS technology
[0049] 1. Inclusion and grouping of research objects
[0050] The included population is from Shenzhen Chronic Hospital, aged 18-60 years, with regular work, rest and diet, and no alcoholism or smoking. The specific groups are as follows:
[0051] (1) The healthy group (45 people) who were not infected with tuberculosis, that is, those who were not infected with Mtb. This group of people had no symptoms and signs of tuberculosis and related mycobacterial diseases, and the gamma interferon release test was negative (excluding the pre-allergy stage; immunization System interference: application of glucocorticoids and other immunosuppressants or malnutrition, measles, pertussis, etc.; immunocompromised: severe tuberculosis, various critically ill patients, lymphocyte system immune deficiency, etc.) (people without PPD, use tuberculosis antibody IgMIgG (Colloidal gold method) in...
Embodiment 3
[0093] Example 3 The verification of the method for distinguishing the patient to be tested as an active pulmonary tuberculosis patient
[0094] The feces of 4 patients with active pulmonary tuberculosis (ATB), 4 cases of Mtb latent healthy people and 6 cases of healthy people without Mtb infection were routinely collected (the feces came from Shenzhen Chronic Hospital, all patients were confirmed by clinical diagnosis, and patients and volunteers All informed), according to the method of judging active pulmonary tuberculosis patients based on feces LC-MS metabolomics analysis technology in Example 1, the relative expression levels of 13 differential metabolites were respectively obtained. 13 differential metabolites including 1-Naphthylamine 1-naphthylamine, Bilirubin bilirubin, delta-Hydroxylysineδhydroxylysine, Docosanamide, Dodemorph, Himbacine, Indolelactic acid , N-Cyclohexylformamide N-cyclohexylformamide, Neotame N-[N-(3,3-dimethylbutyl)-L-α-aspartyl]-L-phenylalanine-1...
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