Paranasal sinus tube stent and preparation method thereof

Abstract

The invention provides a paranasal sinus tube stent and a preparation method thereof. The preparation method comprises the following steps: providing a preset thermoplastic degradable polymer, printing the thermoplastic degradable polymer into a thin sheet on an XOY plane by adopting a 3D printing technology, curling the thin sheet around a preset reference axis to form an annular structure, pre-fixing, and carrying out heat treatment shaping on the annular structure to obtain a hollow stent, and forming a porous drug carrying layer on the surface of the hollow stent, and carrying out hole sealing treatment on the porous drug carrying layer to obtain the sinus canal stent. The preparation method provided by the invention is not limited by the precision of a fused deposition type 3D printerinstrument, and ensures the consistency of forming conditions of all parts of the stent, so that the stent has good elasticity, the stent can be effectively prevented from escaping from a matrix in adeployment process, subsequent sudden release of drugs can be effectively prevented, and meanwhile, the problem of insufficient drug carrying capacity is also avoided, and thus the probability of medical accidents such as secondary blockage caused by the fact that granulation tissues of the nasal cavity grow into the space of the nasal cavity is prevented.

Description

technical field [0001] The invention belongs to the technical field of biomedical devices, and in particular relates to a sinus tube bracket and a preparation method thereof. Background technique [0002] Nasal obstruction is a common clinical disease. It often leads to poor breathing of patients, and even causes facial mutilation and paralysis, which directly affects people's normal life. At present, the main method of interventional therapy is to use the catheter delivery system to send the drug-eluting stent on the surface into the blocked nasal cavity, which can not only expand the narrow nasal cavity, but also use the drug to achieve the repair function. [0003] The disadvantages of the existing stent preparation technology are: the nasal cavity of different individuals has different requirements for the stent size, the stent prepared by the traditional method is low in efficiency, the repeatability is poor, and the size is difficult to adjust in time. Higher, the wa...

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Problems solved by technology

[0003]The defect of the existing stent preparation technology is that: the nasal cavity of different individuals has different requirements for the stent size, and the stent prepared by the traditional method has low efficiency, poor repeatability and large size Difficult to adjust in time, the cost of using laser engraving to prepare side hollow brackets is high, and the wall thickness is not easy to control

For the preparation of tubular stents, the conventional stacking technology in the Z-axis direction has the following defects: (1) The preparation of stents with small diameters and complex pattern structures on the surface is difficult to achieve due to the limitation of instrument precision; (2) The stents prepared by stacking in the Z-axis direction The wall thickness needs to be thicker, otherwise it is difficult to achieve the requirement of high vertical stacking height; (3) Due to the limitation of wall thickness, the polymer material scaffold prepared by stacking in the Z-axis direction of 3D printing is hard and brittle and has almost no self-expanding performance

The stent wall produced by stacking 3D printing in the Z-axis direction is too thick and inelastic. The tubular 3D printing method has high requirements on the instrument itself and is not easy to obtain, and increases the cost of the stent. Limiting the implantation into the human body has a great medical risk, and the degradation cycle of the stent is not synchronized with the tissue healing cycle, the welding edge caused by hot gas welding is broken due to stress concentration, and key technical issues such as drug release rate and drug dose control waiting to be solved

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