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Composite absorbable interface screw and preparation method thereof

A technology of interface screws and composite materials, applied in medical science, surgery, etc., can solve problems such as complex process, influence of screw tooth shape, unfavorable clinical application, etc., and achieve the effect of environmental friendliness, high reliability, and simple manufacturing process

Pending Publication Date: 2020-08-07
花沐医疗科技(上海)有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The process is relatively complicated, and the heat sealing temperature is between 55-85°C. After the screw is heated, the surface softens and slightly melts. After being wrapped with the mesh structure by pressure heat sealing, it may affect the tooth shape of the screw, which is not conducive to its clinical application.

Method used

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  • Composite absorbable interface screw and preparation method thereof
  • Composite absorbable interface screw and preparation method thereof
  • Composite absorbable interface screw and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] This embodiment provides a composite absorbable interface screw, which is composed of poly-L-lactic acid (PLLA) and biphasic calcium phosphate; in this embodiment, the biphasic calcium phosphate includes hydroxyapatite (HA) and β - Tricalcium phosphate (β-TCP), by regulating the content of hydroxyapatite (HA) and β-tricalcium phosphate (β-TCP) in the biphasic calcium phosphate, to achieve the early stage of β-tricalcium phosphate (β-TCP) ) fast absorption, and later hydroxyapatite (HA) neutralizes the effect of lactic acid. While obtaining a high-strength composite absorbable interface screw, the preparation process is simple, no organic solvent or acid is needed, and the invention is environmentally friendly.

[0026] In this embodiment, in the material of the composite absorbable interface screw, the weight percentage of poly-L-lactic acid (PLLA) is 60-80%, and the weight percentage of hydroxyapatite (HA) is 15-30%; β- The weight percentage of tricalcium phosphate (β...

Embodiment 2

[0030] This embodiment provides a method for preparing a composite absorbable interface screw, including:

[0031] (1) Dry the PLLA, β-TCP and HA separately, and then mechanically stir and mix the three according to a certain ratio, such as the ratio in Example 1.

[0032] (2) Melt blending the homogeneously mixed materials:

[0033] a. First, set the temperature of the melting zone (upper, middle and lower) of the blender to 190-220°C, the best is 200°C, the screw speed is 10-30 rpm, the best speed is 20 rpm, and then the Mix the uniform material, slowly pour it into the hopper to get the material rod;

[0034] b. Granulating the extruded rod to obtain composite material particles.

[0035] (3) Precision injection molding to obtain interface screws:

[0036] a. Add the composite material particles into the storage tank of the micro-screw precision injection molding machine;

[0037] b. Turn on the temperature of the electric heating system of the micro-screw precision inj...

Embodiment 3

[0040] This embodiment provides a composite absorbable interface screw, the weight percentage of the poly-L-lactic acid (PLLA) is 60%, the weight percentage of hydroxyapatite (HA) (200nm) is 30%, and β-tricalcium phosphate The weight percentage of (β-TCP) (10um) is 10%.

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Abstract

The invention discloses a composite absorbable interface screw and a preparation method thereof. The composite absorbable interface screw is prepared by compounding poly-L-lactic acid (PLLA) and biphasic calcium phosphate, the ratio of hydroxyapatite (HA) to beta-tricalcium phosphate (beta-TCP) in biphasic calcium phosphate is regulated to reach an effect of matching the polylactic acid degradation rate; meanwhile, the preparation process adopts blending granulation by virtue of a simple double-screw blending machine, and then carries out injection molding by virtue of a single-screw injectionmolding machine. The preparation process is simple, high in reliability, does not use organic solvent or acid, and is environment-friendly.

Description

technical field [0001] The invention relates to a composite absorbable interface screw and a preparation method thereof, belonging to the technical field of medical equipment. Background technique [0002] Anterior cruciate ligament (ACL) reconstruction is one of the most widely used sports medicine today. At present, there are metal interface screws, polyether ether ketone (PEEK) and absorbable interface screws (with or without sheath) in clinical practice. Among them, the absorbable interface screw is the current trend of ACL reconstruction surgery due to its small shear to the ligament, absorbability, and perfect biological fusion of bone and ligament, but there are also a series of problems. [0003] For example, the pure polylactic acid interface can absorb screws, degrade slowly, and produce a large amount of lactic acid in the middle and late stages, triggering an inflammatory response. The polylactic acid / hydroxyapatite (HA) composite interface screw, due to the pr...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L31/12A61L31/14
CPCA61L31/127A61L31/148C08L67/04
Inventor 胡艳飞
Owner 花沐医疗科技(上海)有限公司
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