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Self-expanding composite bone cement and preparation method thereof

A bone cement and self-expanding technology, which is applied in the preparation of the composite bone cement and in the field of self-expanding composite bone cement, can solve the problems of low expansion rate of bone cement, low expansion rate of bone cement, uneven expansion effect, etc. The effect of water absorption time, improvement of mechanical properties, and good application prospects

Active Publication Date: 2020-07-31
XIAN UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0007] The purpose of the present invention is to provide a self-expanding composite bone cement, which solves the problems of low water absorption expansion rate and uneven expansion effect in the prior art.
[0008] Another object of the present invention is to provide the preparation method of the above-mentioned composite bone cement, which solves the problems of low bone cement expansion rate and uneven expansion effect in the prior art

Method used

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  • Self-expanding composite bone cement and preparation method thereof

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preparation example Construction

[0033] A preparation method of self-expanding composite bone cement, specifically comprising the following steps:

[0034] Step 1, preparing polymethyl methacrylate-acrylic acid-anhydrous calcium hydrogen phosphate copolymer microspheres;

[0035] Step 2, preparing the solid phase of the self-expanding composite bone cement: tetracalcium phosphate, anhydrous calcium hydrogen phosphate and the polymethyl methacrylate-acrylic acid-anhydrous calcium hydrogen phosphate copolymer microspheres prepared in step 1 as required Mix evenly in proportion to obtain the solid phase of self-expanding composite bone cement;

[0036] Step 3, the solid phase of the self-expanding composite bone cement obtained in step 2 is 1g:1.5ml~1g:7.2ml according to the solid-liquid ratio, and the liquid phase components are evenly mixed and stirred for 20min~90min, and the bone cement is solidified after injection, and the self-expanding composite bone cement is obtained. Expandable composite bone cement. ...

Embodiment 1

[0049] Step 1, the preparation of PMMA-PAA-PDCPA copolymer microspheres:

[0050] Adopt solution polymerization method to prepare PMMA-PAA-PDCPA copolymer: methyl methacrylate (MMA) and acrylic acid (AA) add 0.1wt% hydroquinone underpressure distillation to remove polymerization inhibitor before use; React in four-necked flask Carry out, four ports in the four-neck flask are respectively connected with nitrogen, magnetic stirring rod, condenser, thermometer; respectively take methyl methacrylate (MMA) 5.622%, acrylic acid (AA) 15.323% after decompression distillation, anhydrous phosphoric acid Hydrogen calcium (DCPA) 0.364%, crosslinking agent N, N methylenebisacrylamide (MBA) 1.457%, dispersant polyvinylpyrrolidone (PVP) 2.127%, initiator azobisisobutyronitrile (AIBN) 0.607% , deionized water 74.5%, total 100%;

[0051] Add MMA, AA and DCPA, cross-linking agent MBA solution, dispersant PVP solution, and initiator AIBN solution into a four-necked flask in sequence and mix eve...

Embodiment 2

[0055] Step 1, the preparation of PMMA-PAA-PDCPA copolymer microspheres:

[0056] Prepare PMMA-PAA-PDCPA copolymer by solution polymerization: Methyl methacrylate (MMA) and acrylic acid (AA) add 1.5wt% hydroquinone to remove polymerization inhibitor under reduced pressure before use. The reaction was carried out in a four-necked flask, and the four ports of the four-necked flask were respectively connected with nitrogen, a magnetic stirring bar, a condenser tube, and a thermometer; respectively, 19.589% of methyl methacrylate (MMA) and acrylic acid (AA) after decompression distillation were taken. 4.700%, anhydrous calcium hydrogen phosphate (DCPA) 0.061%, crosslinking agent N, N methylenebisacrylamide (MBA) 0.972%, dispersant polyvinylpyrrolidone (PVP) 1.214%, initiator azobisisobutyl Nitrile (AIBN) 0.243%, deionized water 73.221%, total 100%;

[0057] Add MMA, AA and DCPA, cross-linking agent MBA solution, dispersant PVP solution, and initiator AIBN solution into a four-nec...

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Abstract

The invention discloses self-expanding composite bone cement and a preparation method thereof. The self-expanding composite bone cement is prepared by mixing a solid-phase component and a liquid-phasecomponent according to a mass-volume ratio of (1g: 1.5 ml) to (1g: 7.2 ml); wherein the solid phase is prepared from the following raw materials in percentage by mass: 30%-70% of polymethyl methacrylate-acrylic acid-anhydrous calcium hydrophosphate copolymer microspheres, 15%-35% of anhydrous calcium hydrophosphate and 15%-35% of tetracalcium phosphate, and the sum of the mass percentages of thecomponents is 100%; and the bone cement liquid phase is any one of distilled water, blood, normal saline, dilute acid, serum and phosphate solution. The prepared self-expanding composite bone cement has high water absorption expansion rate and good mechanical properties, and is expected to become promising bone cement for clinical application.

Description

technical field [0001] The invention belongs to the technical field of biomedical materials and preparation methods, relates to a self-expanding composite bone cement, and also relates to a preparation method of the composite bone cement. Background technique [0002] Polymethyl methacrylate (PMMA) bone cement is widely used in the fields of dentistry, orthopedic surgery, orthopedic surgery, and is the most widely used, most numerous, and most used injectable biomaterial in orthopedics. However, PMMA bone cement will produce a certain volume shrinkage during solidification, which will lead to a series of problems such as loosening. Therefore, researchers have developed water-absorbable bone cement for the problems existing in PMMA bone cement. [0003] The Chinese patent "An Injectable Expandable Bone Cement and Its Preparation Method" (application number: 201510344651.7, publication date: 2015.09.23, publication number: CN104922733A) discloses an injectable expandable bone ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/12A61L27/50A61L27/16
CPCA61L27/12A61L27/16A61L27/50A61L2400/06A61L2430/02C08L51/10
Inventor 汤玉斐魏敏陈磊赵康吴子祥张博王月
Owner XIAN UNIV OF TECH
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