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Anti-dementia medicine

A technology for drugs and dementia, applied in drug combinations, pharmaceutical formulations, plant raw materials, etc., can solve the problems of immature and unpromoted treatment methods.

Pending Publication Date: 2020-07-31
GUANGXI MEDICAL UNIVERSITY
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  • Description
  • Claims
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AI Technical Summary

Problems solved by technology

At present, the research on AD in developed countries such as Europe and the United States has entered the gene and other molecular levels. It is proposed to use genetic engineering to increase the content of nerve growth factors and neurotrophic factors in the damaged area, promote the repair of damaged neurons, and restore their functions. The technology of this treatment method is still immature, so it has not been promoted clinically

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Embodiment Construction

[0005] Describe content of the present invention in detail below in conjunction with embodiment:

[0006] Preparation of DMDD: Take 12 kg of sun-dried carambola root medicinal material, grind it into a coarse powder, add 8 times the amount of ethanol-water (3:2), soak for 30 minutes, and directly heat and reflux under normal pressure to extract 3 times (3 × 96L), Each time for 1 hour, filter, combine the alcohol extracts, and recover ethanol under reduced pressure at 60°C, extract the concentrated solution with 3 times the amount of cyclohexane, ethyl acetate, and n-butanol for 3 times, and combine the extractions liquid; at room temperature, concentrated under reduced pressure and dried to obtain extracts and residues of cyclohexane, ethyl acetate and n-butanol, respectively.

[0007] Take the cyclohexane extract (10.3g), mix it with 10g of chromatographic silica gel, and install it on an open silica gel column (3×80cm, 200-300 mesh) with 10 times the amount. Cyclohexane-eth...

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Abstract

Carambola roots belong to dry roots of oxalidaceae plant carambola trees. The inventor performs a large amount of long-term pharmacodynamic research on carambola roots. On the basis of the research, the research on a carambola root extract 2-dodecyl-6-methoxy-2,5-diene-1,4-cyclohexanedione (DMDD) finds that the carambola root extract has an obvious treatment effect on APP / PS1 dementia model mice.The invention may provide a new anti-dementia drug for senile dementia patients.

Description

technical field [0001] The invention relates to an anti-dementia drug, which is an anti-dementia drug made of Chinese herbal medicine. Background technique [0002] Alzheimer's disease (AD), also known as senile dementia, is a disease that affects the elderly, with senile plaques (SP), neurofibrillary tangles (NFT) and neuronal loss as the main pathological A progressive neurodegenerative disease of the central nervous system, the main clinical symptoms of which are the continuous decline and deterioration of cognitive function and memory function, the progressive decline of directional judgment, comprehension ability, language function, living ability and other functions, and abnormal mental and behavioral performance, etc. . The incidence of AD increases with age, and its incidence is second only to heart disease in the elderly population. Due to the characteristics of insidious onset, slow course and irreversibility of AD, the memory function, visuospatial function, cog...

Claims

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Application Information

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IPC IPC(8): A61K31/122A61P25/28A61K36/185
CPCA61K31/122A61P25/28A61K36/185
Inventor 黄仁彬徐小惠韦晓洁韦锦斌林兴梁韬张宏亮卢顺玉吴兴春覃陆慧
Owner GUANGXI MEDICAL UNIVERSITY
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