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Smearing type biodegradable extravascular stent and preparation method thereof

A technology for external stents and blood vessels, which is applied in the fields of extravascular stents and their preparation, smear-type biodegradable extravascular stents and their preparations, and can solve the problems of single form of extravascular stents and complicated preparation process, and achieve biocompatibility Excellent, high viscosity, antithrombotic effect

Active Publication Date: 2020-07-28
RENMIN UNIVERSITY OF CHINA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Aiming at the problem that the existing extravascular stent has a single form, complicated preparation process, and cannot adapt to complicated clinical situations, the present invention provides a smear-type degradable artificial Extravascular stent

Method used

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  • Smearing type biodegradable extravascular stent and preparation method thereof
  • Smearing type biodegradable extravascular stent and preparation method thereof
  • Smearing type biodegradable extravascular stent and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0054] Embodiment 1, preparation of extravascular stent hydrogel composite solution

[0055] (1) The raw materials used in the hydrogel composite solution in this embodiment are composed of the following, in terms of mass percentage: gelatin 10.0%, bacterial cellulose 0.6%, endothelial hyperplasia inhibitor rapamycin 1.0%, glutamine transaminase 16.7% , 71.7% sterile PBS solution.

[0056] (2) The preparation steps are as follows:

[0057] 1) Add gelatin, bacterial cellulose, and rapamycin, a drug for inhibiting endothelial hyperplasia, into a square petri dish in sequence, and irradiate with ultraviolet light for 12-24 hours.

[0058] 2) Add the irradiated gelatin, bacterial cellulose, anti-endothelial hyperplasia drug rapamycin and sterile PBS solution in 1) into the Shu Niu bottle, and then heat it with magnetic stirring at 30-35°C for 1 hour to make the components All dissolved to form a mixture (hydrogel solution).

[0059] 3) Add transglutaminase to the suspension.

Embodiment 2

[0060] Embodiment 2, preparation of extravascular stent hydrogel composite solution

[0061] (1) The raw materials used in the hydrogel composite solution in this embodiment are composed of the following, in terms of mass percentage: gelatin 15.0%, bacterial cellulose 0.6%, endothelial hyperplasia inhibitor rapamycin 1.0%, glutamine transaminase 16.7% , sterile PBS solution 66.7%.

[0062] (2) The preparation steps are as follows:

[0063] 1) Add gelatin, bacterial cellulose, and rapamycin, a drug for inhibiting endothelial hyperplasia, into a square petri dish in sequence, and irradiate with ultraviolet light for 12-24 hours.

[0064] 2) Add the irradiated gelatin, bacterial cellulose, anti-endothelial hyperplasia drug rapamycin and sterile PBS solution in 1) into the Shu Niu bottle, and then heat it with magnetic stirring at 30-35°C for 1 hour to make the components All dissolved to form a mixture (hydrogel solution).

[0065] 3) Add transglutaminase to the suspension.

Embodiment 3

[0066] Embodiment 3, preparation of extravascular stent hydrogel composite solution

[0067] (1) The raw materials used in the hydrogel composite solution in this embodiment are composed of the following, in terms of mass percentage: 20.0% gelatin, 0.6% bacterial cellulose, 1.0% anti-endothelial hyperplasia drug rapamycin, and 16.7% transglutaminase , sterile PBS solution 61.7%.

[0068] (2) The preparation steps are as follows:

[0069] 1) Add gelatin, bacterial cellulose, and anti-endothelial hyperplasia drugs to a square petri dish in sequence, and irradiate with ultraviolet light for 12-24 hours.

[0070] 2) Add the irradiated gelatin, bacterial cellulose, anti-endothelial hyperplasia drug rapamycin and sterile PBS solution in 1) into the Shu Niu bottle, and then heat it with magnetic stirring at 30-35°C for 1 hour to make the components All dissolved to form a mixture (hydrogel solution).

[0071] 3) Add transglutaminase to the suspension.

[0072] The shear thinning ...

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Abstract

The invention discloses a smearing type biodegradable extravascular stent and a preparation method thereof. A hydrogel composite solution is prepared from the following components: 10-20 wt% of gelatin, 5-20 wt% of biological enzyme, 0.1-1 wt% of bacterial cellulose and the balance of a solvent. The hydrogel composite solution is high in viscosity and high in gelatinizing speed, can coat the outerwall of a blood vessel in a smearing manner, greatly reduces the operation difficulty, and is suitable for complex conditions in a clinical transplantation operation. The extravascular stent materialis derived from bio-based macromolecules, the biocompatibility is excellent, the degradation product is safe and non-toxic, and the potential risk of anaphylactic reaction or toxic reaction does notexist. The hydrogel intravascular stent loaded with the medicine for inhibiting endothelial hyperplasia has an external supporting effect on grafted veins, and can prevent and treat excessive proliferation of intravenous intima through the medicine.

Description

technical field [0001] The invention relates to an extravascular stent and a preparation method thereof, in particular to a smear-type biodegradable extravascular stent and a preparation method thereof, belonging to the field of tissue engineering. Background technique [0002] Atherosclerosis is one of the major diseases that threaten human health and cause death in the world today. Coronary artery bypass grafting is the mainstay of treatment for patients with advanced coronary heart disease. Although arterial blood vessels have their own advantages as graft vascular materials, for most patients, autologous great saphenous vein is still necessary and the most commonly used graft vascular material. However, after the operation, the venous graft suddenly bears high arterial pressure, the hemodynamics changes, the tension of the vessel wall increases significantly, and the excessive expansion of the graft causes the wall damage. Migrate to the intima through the inner elasti...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08J3/075C08J3/28C08L89/00C08L1/02A61L31/04A61L31/14A61L31/16
CPCC08J3/075C08J3/28A61L31/045A61L31/047A61L31/042A61L31/16A61L31/148A61L31/145A61L2300/416A61L2300/42C08J2389/00C08J2401/02C08J2489/00C08L89/00C08L1/02
Inventor 王亚培周游
Owner RENMIN UNIVERSITY OF CHINA
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