Application of h.hathewayi or taurine as a medicine for preventing and treating intracranial aneurysm formation and rupture

A technology of intracranial aneurysm and taurine, which is applied in the field of medicine, can solve the problems of bleeding risk and complications, reduce the formation and rupture of intracranial aneurysm, promote the increase, inhibit the activation of matrix metalloproteinase and the blood vessel wall Effects of extracellular matrix degradation

Active Publication Date: 2021-11-02
FUWAI HOSPITAL CHINESE ACAD OF MEDICAL SCI & PEKING UNION MEDICAL COLLEGE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] For ruptured intracranial aneurysms, there is consensus that endovascular therapy or surgical treatment must be performed, but the treatment of non-ruptured intracranial aneurysms is currently controversial, even if endovascular treatment is performed for intracranial aneurysms at risk of rupture Or surgical treatment, there is still a greater risk of bleeding and complications

Method used

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  • Application of h.hathewayi or taurine as a medicine for preventing and treating intracranial aneurysm formation and rupture
  • Application of h.hathewayi or taurine as a medicine for preventing and treating intracranial aneurysm formation and rupture
  • Application of h.hathewayi or taurine as a medicine for preventing and treating intracranial aneurysm formation and rupture

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0066] Example 1: Changes in the level of gut microbial species in patients with intracranial aneurysms compared to controls revealed by metagenomics sequencing

[0067] 1. Materials and Instruments

[0068] In this example, the Illumina HiSeq X Ten sequencing platform was used to sequence the collected human intestinal microbial DNA samples, and then the sequencing data were subjected to biological species annotation, species quantification and related bioinformatics analysis.

[0069] 2. Method

[0070] 2.1 From 2016 to 2018, 100 patients with non-ruptured intracranial aneurysms and 100 matched control populations (the first population) were enrolled in Beijing Tiantan Hospital and Hebei Cangzhou Central Hospital, and their stool samples and Plasma samples. In this study, from 2017 to 2018, 40 patients with non-ruptured intracranial aneurysms and matched control groups with corresponding clinical parameters were enrolled in Beijing Tiantan Hospital, Chinese People's Libera...

Embodiment 2

[0083] Example 2: Exploring the functional changes of gut microbes and their association with plasma metabolites in patients with intracranial aneurysm through population gut metagenomics and plasma metabolomics

[0084] 1. Materials and Instruments

[0085] In this example, the UPLC-MS / MS system was used to detect the metabolites (amino acids and free fatty acids) in the plasma of the population by targeted metabolomics.

[0086] 123 standard amino metabolites were purchased from Sigma-Aldrich (Shanghai) Trading Co., Ltd. (Sigma-Aldrich, USA) and Beijing Bailingwei Technology Co., Ltd. (J&K, China; TRC, Canada). Boronic acid, N-ethylmaleimide (NEM), 4-tert-butylthiophenol (tBBT), dimethylsulfoxide (DMSO), 5-aminoisoquinoline (5AIQ), N,N' -Disuccinimidyl carbonate (DSC), ascorbic acid (Vc), ethylenediaminetetraacetic acid (EDTA) and tris(2-carboxyethyl)phosphine (TCEP) were purchased from Sigma-Aldrich (Shanghai) Trading Ltd. (Sigma-Aldrich, USA), analytically pure dipotassi...

Embodiment 3

[0100] Example 3: Feces from patients with intracranial aneurysms are more likely to cause the formation and rupture of intracranial aneurysms in mice than feces from normal people through fecal transplantation experiments

[0101] 1. Materials and Instruments

[0102] Table-3 Materials and instruments required for preparation and evaluation of mouse intracranial aneurysm model

[0103]

[0104]

[0105] 2. Method

[0106] 2.1 Donor feces acquisition

[0107] From 2017 to 2018, 2 cases of feces from patients with intracranial aneurysms and 2 cases of normal controls were collected in the General Hospital of the Chinese People's Liberation Army and Tsinghua University Hospital for mouse fecal transplantation experiments. Donor clinical information is as follows:

[0108] Table 4 Donor clinical characteristics

[0109]

[0110] 2.2 Experimental animals

[0111] The experimental design complied with the implementation rules for the management of medical experimental...

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Abstract

The invention provides an application of H. hathewayi or taurine as a medicine for preventing and treating intracranial aneurysm formation and rupture. The present invention discloses that supplementation of H. hathewayi promotes the increase of plasma taurine level, and ultimately reduces the formation and rupture of intracranial aneurysm. Direct supplementation of taurine can also reduce the formation and rupture of intracranial aneurysms.

Description

technical field [0001] The invention belongs to the field of medicine, and relates to the application of drugs for preventing and treating intracranial aneurysm formation and rupture, in particular to the application of Hungatella hathewayi (H.hathewayi) and taurine in the preparation of drugs for preventing and treating intracranial aneurysm formation and rupture . Background technique [0002] Intracranial aneurysm is one of the major diseases that seriously endanger human health and is the main cause of sudden death in humans. The incidence of intracranial aneurysms in the world population is about 3.2%. The bleeding age is mostly 40-70 years old. Community surveys in China have shown that the prevalence of non-ruptured intracranial aneurysms in Chinese adults is as high as 7%. Intracranial aneurysm is a very dangerous cerebrovascular disease, most of the subarachnoid hemorrhage is caused by rupture of aneurysm. In the United States, the number of patients with subara...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K35/74A61K31/185A61P35/00A61P21/00A61P29/00A61P9/00
CPCA61K31/185A61K35/74A61P9/00A61P21/00A61P29/00A61P35/00
Inventor 陈敬洲李昊徐昊辰温红艳葛菁柳婷婷田雪晴王旭粱宋莉张银辉孙莹莹陶瑾
Owner FUWAI HOSPITAL CHINESE ACAD OF MEDICAL SCI & PEKING UNION MEDICAL COLLEGE
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