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Method for improving immunopotentiation capacity of chitosan

A technology for chitosan and immune enhancement, applied in the biological field, can solve problems such as restricting application, and achieve the effects of improving in vitro antioxidant capacity, enhancing anti-tumor immunity, and significantly biocatalytic effect.

Inactive Publication Date: 2020-07-28
梁志勇
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, there are relatively few studies on the degradation of chitosan and the improvement of antioxidant capacity, especially for the improvement of chitosan's ability to enhance anti-tumor immunity is a key technical drawback in this field, which restricts its application in functional foods and medical foods. application

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] A method for improving chitosan immune enhancing ability, characterized in that it specifically comprises the following steps:

[0033] (1) Ingredients: accurately mix according to the ratio of 100 parts of chitosan, 30 parts of Codonopsis pilosula, and 20 parts of Chuanxiong, crush chitosan, Codonopsis and Chuanxiong through a 100-mesh sieve, and set aside;

[0034] (2) Chinese herbal medicine enzymatic hydrolysis: mix Codonopsis pilosula and Chuanxiong, then add pure water with a mass ratio of 10 times, stir for 10 minutes, then add 2-3% cellulase and 1-2% non-starch polysaccharase with the mass ratio of Chinese herbal medicine raw materials , enzymatic hydrolysis at 40-60°C for 4 hours with the assistance of ultrasonic waves;

[0035] (3) Chitosan enzymatic hydrolysis: add 5 times of pure water to the pulverized chitosan, add a compound enzyme preparation with a mass ratio of 2%, and stir the enzymolysis at 40-60°C for 30 minutes; The compound enzyme preparation is ...

Embodiment 2

[0043] A method for improving chitosan immune enhancing ability, characterized in that it specifically comprises the following steps:

[0044] (1) Ingredients: accurately mix according to the ratio of 100 parts of chitosan, 20 parts of Codonopsis pilosula, and 10 parts of Chuanxiong, crush chitosan, Codonopsis and Chuanxiong through a 100-mesh sieve, and set aside;

[0045] (2) Chinese herbal medicine enzymatic hydrolysis: mix Codonopsis pilosula and Chuanxiong, then add pure water with a mass ratio of 10 times, stir for 10 minutes, then add 2-3% cellulase and 1-2% non-starch polysaccharase with the mass ratio of Chinese herbal medicine raw materials , enzymatic hydrolysis at 40-60°C for 4 hours with the assistance of ultrasonic waves;

[0046] (3) Chitosan enzymatic hydrolysis: add 5 times of pure water to the pulverized chitosan, add a compound enzyme preparation with a mass ratio of 2%, and stir the enzymolysis at 40-60°C for 30 minutes; The compound enzyme preparation is ...

Embodiment 3

[0054] A method for improving chitosan immune enhancing ability, characterized in that it specifically comprises the following steps:

[0055] (1) Ingredients: accurately mix according to the ratio of 100 parts of chitosan, 25 parts of Codonopsis pilosula, and 15 parts of Chuanxiong, crush chitosan, Codonopsis and Chuanxiong through a 100-mesh sieve, and set aside;

[0056] (2) Chinese herbal medicine enzymatic hydrolysis: mix Codonopsis pilosula and Chuanxiong, then add pure water with a mass ratio of 10 times, stir for 10 minutes, then add 2-3% cellulase and 1-2% non-starch polysaccharase with the mass ratio of Chinese herbal medicine raw materials , enzymatic hydrolysis at 40-60°C for 4 hours with the assistance of ultrasonic waves;

[0057] (3) Chitosan enzymatic hydrolysis: add 5 times of pure water to the pulverized chitosan, add a compound enzyme preparation with a mass ratio of 2%, and stir the enzymolysis at 40-60°C for 30 minutes; The compound enzyme preparation is ...

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PUM

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Abstract

The invention discloses a method for improving immunopotentiation capacity of chitosan, and belongs to the field of a biological technology. The chitosan is used as a raw material, radix codonopsis and ligusticum wallichii are used as auxiliary materials, and a modern bioseparation technique, a biological enzymolysis technique and a mixed bacterium microorganism fermentation technique are integrated, so that a chitosan extracting solution high in in-vitro antioxidant ability is developed. Mixed bacterium aerobic zymocyte mainly comprises candida utilis, bacillus siamensis and bacillus subtilis. The obtained chitosan extracting solution has notable efficacy of being nutritive and health-care, and can meet efficient utilization requirements of fields of health care, foods, medicines and thelike. The technology is simple and efficient in technique, and the obtained products are good in immunopotentiation and antitumous effects, and high in stability and have high market application prospects.

Description

technical field [0001] The invention relates to a method for improving the immune enhancing ability of chitosan, especially a chitosan biological product with high immune enhancing ability prepared by using chitosan as a raw material through enzymolysis and microbial fermentation, which belongs to biotechnology field. Background technique [0002] Chitin is known as "the last renewable resource on the earth". With the deepening of research, its potential value has been continuously discovered, especially chitosan, which has gradually become a new favorite in the field of health care. Chitosan, also known as chitin, chitosan, chitosamine, deacetylated chitin and base polyacid, etc., is a positively charged, cationic and alkaline edible cellulose; because chitosan has It has multiple health functions, and is praised by nutritionists as the sixth life element after protein, fat, carbohydrates, vitamins and mineral elements. The nutritional and medical effects of chitosan can ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A23L33/125A23L33/10A23L29/00A61K36/344A61P37/04A61P35/00C12N1/18C12N1/20C12P19/16C12P19/04C12P39/00C12P1/02C12P1/04C12R1/72C12R1/125C12R1/07A61K31/722
CPCA23V2002/00A61K31/722A61K36/236A61K36/344A61K2236/19A23L29/06A23L29/065A23L33/10A23L33/125A61P35/00A61P37/04C12N1/18C12N1/20C12P1/02C12P1/04C12P19/04C12P19/16C12P39/00C12N1/165C12N1/205C12R2001/07C12R2001/125C12R2001/72A23V2200/308A23V2200/324A23V2250/511A23V2300/50A61K2300/00
Inventor 梁志勇王冠丹孙倩王晓瞳
Owner 梁志勇
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