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Magnetic fluorescent mesoporous silica composite nano material and preparation method thereof

A technology of mesoporous silica and composite materials, applied in luminescent materials, chemical instruments and methods, material analysis through optical means, etc., can solve the problems of poor early diagnosis accuracy of diseases, difficulty in diagnosis and treatment of composite nanomaterials, inability to Both treatment and other issues can be achieved to improve the user experience, uniform appearance, and avoid misjudgment

Inactive Publication Date: 2020-07-17
HUAZHONG UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0006] Aiming at the defects of the prior art, the purpose of the present invention is to provide a magnetic fluorescent mesoporous silica composite nanomaterial and its preparation method, which realizes the integration of the functions of each component and complementary defects, and aims to solve the problem that the existing composite nanomaterials are difficult to obtain. Integrating diagnosis and treatment functions into one, leading to poor early diagnosis accuracy and technical problems of treatment

Method used

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  • Magnetic fluorescent mesoporous silica composite nano material and preparation method thereof
  • Magnetic fluorescent mesoporous silica composite nano material and preparation method thereof
  • Magnetic fluorescent mesoporous silica composite nano material and preparation method thereof

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preparation example Construction

[0049] The core of the invention is to propose a magnetic fluorescent mesoporous silica composite material and a corresponding preparation method. The composite material has a core-shell structure, the core is a magnetic nano particle, the shell is a mesoporous silicon dioxide material, and quantum dot materials are grown in the apertures of the silicon dioxide material. The above preparation method includes: first preparing magnetic nanoparticles, then modifying the magnetic nanoparticles with a surfactant, mixing them into the mesoporous silica precursor solution, and preparing magnetic mesoporous silica particles with a core-shell structure by a sol-gel method , and finally the quantum dot material was grown in situ in the aperture of magnetic mesoporous silica nanoparticles by solvothermal method. details as follows:

[0050] Such as figure 1 , the present invention provides a magnetic fluorescent mesoporous silica composite material, which is a core-shell structure, inc...

Embodiment 1

[0081] Such as figure 1 As shown, the magnetic fluorescent mesoporous silica composite material provided in this example has a core-shell structure, including magnetic nanoparticles 1, mesoporous silica 2 and quantum dot materials 3; the core is magnetic nanoparticles 1, and the shell is mesoporous The porous silicon dioxide 2 and the quantum dot material 3 are located in the pores of the mesoporous silicon dioxide 2 .

Embodiment 2

[0083] In this embodiment, the magnetic nanoparticles are ferric oxide, the surfactant is cetyltrimethylammonium bromide (CTAB), and the quantum dot material is CsPbBr 3 ; The specific preparation process is as follows:

[0084] (1) Preparation of magnetic nanoparticles: ferric oxide

[0085] Dissolve 10.8g of ferric chloride hexahydrate (40mmol) and 36.5g of sodium oleate (20mmol) in a mixed solvent consisting of 80mL of ethanol, 60mL of distilled water and 140mL of hexane, heat to 70°C and keep for 4h;

[0086] After the reaction was completed, wash the upper organic matter containing iron oleate complex three times in a separating funnel with 30mL distilled water to obtain waxy iron oleate complex;

[0087] Dissolve 36g of the above synthesized iron oleate complex (40mmol) and 5.7g of oleic acid (20mmol) in 200g of octadecene at room temperature, heat to 320°C at a constant heating rate of 3.3°C / min, and keep for 30min ;

[0088] The above-mentioned solution containing t...

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Abstract

The invention discloses a magnetic fluorescent mesoporous silica composite nano material and a preparation method thereof, and belongs to the field of nano composite materials. The composite materialis of a core-shell structure, a core is a magnetic nanoparticle and is used as a contrast agent for nuclear magnetic resonance imaging, a thermal release agent in magnetic thermal therapy and a driverfor targeted drug therapy, the shell is mesoporous silica and is used as a drug or gene carrier, and the quantum dot material is located in the pore diameter of the mesoporous silica and is used as afluorescent probe. The method comprises the following steps: preparing magnetic nanoparticles by using a solvothermal method, modifying the magnetic nanoparticles with a surfactant, mixing the magnetic nanoparticles with a mesoporous silica precursor solution, after mixing, preparing magnetic mesoporous silica nanoparticles with a core-shell structure by adopting a sol-gel method, and enabling the quantum dot material to grow in situ in the aperture of the magnetic mesoporous silica nanoparticle by adopting a thermal injection method. The composite material provided by the invention integrates diagnosis and treatment functions, and can improve the diagnosis accuracy and the treatment efficiency.

Description

technical field [0001] The invention belongs to the field of nanocomposite materials, and more specifically relates to a magnetic fluorescent mesoporous silica composite nanomaterial and a preparation method thereof. Background technique [0002] In recent years, with the continuous development of nanotechnology, the design and preparation of multi-component composite nanomaterials has gradually become a research hotspot. Among them, nanomaterials with magnetic, fluorescent, and carrier functions have received special attention and have important application prospects. For example: if the combination of multifunctional nanomaterials and drug molecules is applied to the tumor drug delivery system, it can realize the real-time guidance of fluorescence imaging and the targeted regulation of cancer treatment by external magnetic field, so as to maximize the efficiency of drug utilization and reduce the effect of drugs on normal cells. tissue damage. [0003] Magnetic nanoparti...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C09K11/66C09K11/02A61K49/18A61K49/00A61K9/51G01N21/64B82Y20/00B82Y30/00
CPCA61K9/5115A61K49/0002A61K49/0093A61K49/1839B82Y20/00B82Y30/00C09K11/025C09K11/665G01N21/6428
Inventor 曹全梁陈竞舸韩小涛李亮
Owner HUAZHONG UNIV OF SCI & TECH
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