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Medicine composition and gel for oral mucosa inflammatory pain and bacteriostasis and preparation method

A technology for inflammatory pain and oral mucosa, which is applied in the field of inflammatory pain and bacteriostatic pharmaceutical composition and its gel and preparation for oral mucosal ulcers. Achieve enhanced antibacterial effect, obvious complementary and synergistic effect, and obvious synergistic effect

Active Publication Date: 2020-07-10
陕西恒远生物科技有限公司 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Since the systemic drug treatment is mostly based on immunomodulators, vitamins or zinc-based trace elements, but the effect is not exact, especially it cannot produce immediate results, so the clinical treatment is mostly local treatment
The dosage forms of topical treatment mainly include water, cream, ointment and film, etc., due to the short maintenance time of the above dosage forms in the oral cavity, the effective concentration of local drugs is low, and the curative effect is easily affected by saliva washing and other reasons

Method used

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  • Medicine composition and gel for oral mucosa inflammatory pain and bacteriostasis and preparation method
  • Medicine composition and gel for oral mucosa inflammatory pain and bacteriostasis and preparation method
  • Medicine composition and gel for oral mucosa inflammatory pain and bacteriostasis and preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0049] A compound gel for oral mucosal ulcer inflammatory pain and antibacterial, according to the mass percentage, prepare the following raw materials: Bufataline 0.1%, dyclonine 1.5%, chitosan quaternary ammonium salt 1.5%, ε- Polylysine 1.5%, hyaluronic acid 1.5%, pearl powder 1.5%, polyvinyl alcohol 1.5%, xylitol 1.5%, absolute ethanol 5.0%, and the balance is water.

[0050] The preparation steps are as follows:

[0051] Step 1: Heat and swell polyvinyl alcohol with purified water in advance, soak chitosan quaternary ammonium salt with purified water for 2 hours, dissolve xylitol and pearl powder with purified water, then mix the three phases and stir evenly to form a gel matrix ;

[0052] Step 2, putting corresponding weights of bufatalin and dyclonine ε-polylysine into a stirring container, stirring and mixing at room temperature to form a low-melting eutectic mixture;

[0053] Step 3, adding the homogeneously mixed gel matrix directly into the above-mentioned stirrin...

Embodiment 2

[0057] A compound gel for oral mucosal ulcer inflammatory pain and antibacterial, according to the mass percentage, prepare the following raw materials: Bufataline 0.3%, dyclonine 3.0%, chitosan quaternary ammonium salt 2.0%, ε- Polylysine 1.5%, hyaluronic acid 2.5%, pearl powder 1.0%, polyvinyl alcohol 2.5%, xylitol 1.0%, absolute ethanol 4.0%, and the balance is water.

[0058] The preparation steps are the same as in Example 1.

Embodiment 3

[0060] A compound gel for oral mucosal ulcer inflammatory pain and antibacterial, according to the mass percentage, prepare the following raw materials: Bufataline 0.5%, dyclonine 2.5%, chitosan quaternary ammonium salt 0.5%, ε- Polylysine 0.5%, hyaluronic acid 1.0%, pearl powder 2.5%, polyvinyl alcohol 2.0%, xylitol 4.0%, absolute ethanol 10.0%, and the balance is water.

[0061] The preparation steps are the same as in Example 1.

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Abstract

The invention discloses a medicine composition and gel for oral mucosa inflammatory pain and bacteriostasis and a preparation method. Bufalin, dyclonine, chitosan quaternary ammonium salt and epsilon-polylysine are used as the medicine composition to treat symptoms of oral ulcer and mucosa inflammatory pain, the medicine composition is a compound preparation according to the mechanism of pain on the surface of oral ulcer and pain causing base of inhibiting multiple microorganisms on the surface of the ulcer, the bufalin and the dyclonine are combined to quickly block pain conduction of exposednerve endings for a long time, food addition of non-western medicine antibiotics and combination of chitosan quaternary ammonium salt and epsilon-polylysine are adopted to effectively kill multiple pathogenic microorganisms on the surface of the ulcer, inflammatory irritation is further reduced, and the healing function of the wound ulcer is promoted.

Description

technical field [0001] The invention belongs to the field of biomedicine and relates to a pharmaceutical composition for oral ulcer, in particular to a pharmaceutical composition for oral mucosal ulcer inflammatory pain and antibacterial, a gel and a preparation method thereof. Background technique [0002] In daily life, the oral cavity is easily damaged by various reasons such as brushing teeth, chewing or washing teeth, filling teeth, and causing various inflammations such as mucosal infection and ulcers. In particular, recurrent oral ulcers, also known as recurrent aphthous ulcers, are a disease with the highest incidence rate among oral mucosal diseases. , trace elements and some vitamin deficiencies, or are closely related to streptococcus and Helicobacter pylori. The main manifestation is that the location of the ulcer wound is not fixed, and it occurs repeatedly. It often appears in the tongue, mouth, and oral mucosa. When the patient eats salty, sour, sweet and oth...

Claims

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Application Information

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IPC IPC(8): A61K31/722A61K9/06A61K47/46A61P1/02A61P23/02A61P29/00A61P31/04A61K31/198A61K31/4453A61K31/585
CPCA61K31/585A61K31/4453A61K31/722A61K31/198A61K9/006A61K9/06A61K47/46A61P31/04A61P1/02A61P29/00A61P23/02A61K2300/00
Inventor 徐礼鲜顾宜王新文李相文冯斌汪苑苑王鹏远
Owner 陕西恒远生物科技有限公司
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