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Injectable composite antibacterial hydrogel and preparation method thereof

A compound antibacterial and injection-type technology, applied in the field of hydrogel, can solve the problems of unstable antibacterial effect, short antibacterial validity period, easy leakage of antibacterial agent, etc.

Active Publication Date: 2020-06-19
CHANGCHUN INST OF APPLIED CHEMISTRY - CHINESE ACAD OF SCI
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Most of the above-mentioned hydrogels prepared by using polyvinyl alcohol are cross-linked between molecular chains through chemical cross-linking agents or physical means. This cross-linking method is irreversible. Most of the materials are blended and doped with substances with antibacterial function to endow the material with antibacterial properties. The materials prepared by this method are release-type antibacterial materials, which generally have the disadvantages of easy leakage of antibacterial agents, unstable antibacterial effect, and short antibacterial validity period.

Method used

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  • Injectable composite antibacterial hydrogel and preparation method thereof
  • Injectable composite antibacterial hydrogel and preparation method thereof
  • Injectable composite antibacterial hydrogel and preparation method thereof

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preparation example Construction

[0022] The invention provides a preparation method of an injectable composite antibacterial hydrogel, comprising the following steps:

[0023] In the presence of a catalyst, the carboxylated polyvinyl alcohol (C-PVA) solution is adjusted to a pH value of 3 to 4 and then reacted with ε-polylysine (EPL) to obtain an amino-modified polyvinyl alcohol solution (CPVA-g- EPL);

[0024] Blending the chitosan (CS) solution, the dextran formaldehyde solution and the amino-modified polyvinyl alcohol solution to obtain an injectable composite antibacterial hydrogel;

[0025] The mass ratio of amino-modified polyvinyl alcohol, chitosan and glucan is 4-1:1:0.05-0.5.

[0026] The method provided by the invention adopts amino-modified polyvinyl alcohol with antibacterial function, and after blending with chitosan, utilizes the amino groups on the molecular chains of the two and the aldehyde groups on the molecular chains of dextran to form a dynamic Schiff base bond , so that the prepared h...

Embodiment 1

[0043] Take 20mL of refined vinyl acetate and add it to 40mL of methanol, pass nitrogen to remove oxygen for 30min, then add 0.02gAIBN, 3mL of acrylic acid, react at 65°C for 8h, the product is precipitated in deionized water, and the product is named P(VAc-co -AA); Then configuration mass percentage is the P (VAc-co-AA) methanol solution of 25%, normal temperature adds the sodium hydroxide methanol solution of an amount of 1mol / L, makes the quality of NaOH and P (VAc-co-AA) The ratio reaches 0.02, after mixing evenly, carry out alcoholysis reaction in a constant temperature water bath at 50°C for 30 minutes to obtain a colloidal product, heat and dissolve the colloidal product with deionized water, filter to remove insoluble impurities, cool to room temperature, and use methanol as a precipitant to precipitate 3 times , filtered, and dried to obtain carboxylated polyvinyl alcohol (C-PVA).

[0044] Add 10mL of deionized water to a 100mL two-necked flask, add 1g of C-PVA, add a...

Embodiment 2

[0053] The experimental steps for preparing carboxylated polyvinyl alcohol (C-PVA), amino acid modified polyvinyl alcohol (CPVA-g-EPL-1) and dextran formaldehyde (ODEX) are the same as in Example 1.

[0054] Take 0.7mL CPVA-g-EPL-1 solution with a mass percentage of 10%, add 1.4mL chitosan solution with a mass percentage of 2.5% and 200μL ODEX solution with a mass percentage of 6%, and mix well at room temperature to prepare a hydrogel Glue, the product number is S2. Antibacterial test results show that the antibacterial rate of S2 against Escherichia coli is 99.96%, and the antibacterial rate against Staphylococcus aureus is 99.98%.

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Abstract

The invention provides injectable composite antibacterial hydrogel and a preparation method thereof. The method comprises the steps that in the presence of a catalyst, a carboxylated polyvinyl alcoholsolution undergoes a reaction with epsilon-polylysine after the pH value is adjusted to 3-4 so that an amino-modified polyvinyl alcohol solution is obtained, and a chitosan solution, an aldehyde dextran solution and the amino-modified polyvinyl alcohol solution are mixed to form the injectable composite antibacterial hydrogel, wherein the mass ratio of the amino-modified polyvinyl alcohol to thechitosan to the hydroformylation glucan is (4-1): 1: (0.05-0.5). According to the method, amino-modified polyvinyl alcohol with an antibacterial function is blended with chitosan, and then a dynamic Schiff base bond is constructed by utilizing amino groups on molecular chains of the polyvinyl alcohol and the chitosan and aldehyde groups on molecular chains of hydroformylation glucan, so that the hydrogel has reversible cross-linking property and is an intrinsic antibacterial material. The antibacterial rate is higher. The highest antibacterial rate of the hydrogel prepared by the embodiment ofthe invention on escherichia coli and staphylococcus aureus reaches 99.99%.

Description

technical field [0001] The invention belongs to the field of hydrogel technology, and in particular relates to an injectable composite antibacterial hydrogel and a preparation method thereof. Background technique [0002] Hydrogel is a cross-linked body composed of natural or synthetic polymers and a certain amount of water. It not only has excellent water absorption, but also has certain elasticity and excellent biocompatibility. It can be used in tissue engineering, drug carriers and cell culture. and other fields (Y.Hao, J.L.He, X.Ma et al, A fully degradable and photo crosslinked polysaccharide-polyphosphate hydrogel for tissue engineering, Carbohydrate Polymers 225(2019) 115257). As a wound dressing, hydrogel should have certain antibacterial properties, because severe wound infection caused by bacteria can lead to sepsis, increasing the risk of amputation and death (P.G.Bowler, Woundpathophysiology, infection and therapeutic options, Ann.Med, 34(2002 ), 419-427.). Ch...

Claims

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Application Information

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IPC IPC(8): C08J3/075C08J3/24C08L87/00C08L5/08C08L5/02C08G81/02
CPCC08G81/024C08J3/075C08J3/246C08J2387/00C08J2405/02C08J2405/08
Inventor 杨旭姬相玲许玖多王宝龙沙迪石凯
Owner CHANGCHUN INST OF APPLIED CHEMISTRY - CHINESE ACAD OF SCI
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