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Traditional Chinese medicine composition for treating stroke, middle meridian, coronary heart disease and angina pectoris caused by obstruction of collaterals by blood stasis and preparation method of traditional Chinese medicine composition

A technology for blood stasis blocking collaterals and coronary heart disease, applied in the field of drug extraction, can solve problems such as unclear indications, poor compliance, and poor pertinence, and achieve the effect of remarkable drug effect, stable and reliable quality, and easy to carry

Active Publication Date: 2020-06-16
吉林修正药业新药开发有限公司 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Poor compliance, weak pertinence, and unclear indications

Method used

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  • Traditional Chinese medicine composition for treating stroke, middle meridian, coronary heart disease and angina pectoris caused by obstruction of collaterals by blood stasis and preparation method of traditional Chinese medicine composition
  • Traditional Chinese medicine composition for treating stroke, middle meridian, coronary heart disease and angina pectoris caused by obstruction of collaterals by blood stasis and preparation method of traditional Chinese medicine composition
  • Traditional Chinese medicine composition for treating stroke, middle meridian, coronary heart disease and angina pectoris caused by obstruction of collaterals by blood stasis and preparation method of traditional Chinese medicine composition

Examples

Experimental program
Comparison scheme
Effect test

specific Embodiment 1

[0111] 1. A preparation method of Chinese medicine extract A for the treatment of apoplexy, middle meridians, coronary heart disease and angina pectoris caused by blood stasis blocking collaterals:

[0112] Take 10 parts of Salvia miltiorrhiza, 0.5 parts of Panax notoginseng, 2 parts of Chuanxiong, 8 parts of kudzu, 5 parts of turmeric, and 10 parts of peach kernel, and reflux extraction 3 times, the first time 10 times the amount of 60% ethanol extraction for 3 hours, the second time 8 6 times the amount of 60% ethanol extraction for 2 hours, the third 6 times the amount of 60% ethanol extraction for 1 hour, combined alcohol extracts, recovered ethanol, concentrated to 1.20 clear paste, dried under reduced pressure, dried paste crushed, powder a.

[0113] Take 8 parts of Epimedium, add 10 times the amount of 50% ethanol to extract at 60°C for 2 hours, recover the ethanol, concentrate under reduced pressure to a thick paste with a relative density of 1.25-1.30, freeze-dry the c...

specific Embodiment 2

[0126] 1. A preparation method of Chinese medicine extract A for the treatment of apoplexy, middle meridians, coronary heart disease and angina pectoris caused by blood stasis blocking collaterals:

[0127] Take 10 parts of Salvia miltiorrhiza, 0.5 parts of Panax notoginseng, 2 parts of Chuanxiong, 8 parts of kudzu, 5 parts of turmeric, and 10 parts of peach kernel, and reflux extraction 3 times, the first time 10 times the amount of 60% ethanol extraction for 3 hours, the second time 8 6 times the amount of 60% ethanol extraction for 2 hours, the third 6 times the amount of 60% ethanol extraction for 1 hour, combined alcohol extracts, recovered ethanol, concentrated to 1.20 clear paste, dried under reduced pressure, dried paste crushed, powder a.

[0128] Take 8 parts of Epimedium, add 10 times the amount of 50% ethanol to extract at 60°C for 2 hours, recover the ethanol, concentrate under reduced pressure to a thick paste with a relative density of 1.25-1.30, freeze-dry the c...

specific Embodiment 3

[0141] 1. A preparation method of Chinese medicine extract A for the treatment of apoplexy, middle meridians, coronary heart disease and angina pectoris caused by blood stasis blocking collaterals:

[0142] Take 10 parts of Salvia miltiorrhiza, 0.5 parts of Panax notoginseng, 2 parts of Chuanxiong, 8 parts of kudzu, 5 parts of turmeric, and 10 parts of peach kernel, and reflux extraction 3 times, the first time 10 times the amount of 60% ethanol extraction for 3 hours, the second time 8 6 times the amount of 60% ethanol extraction for 2 hours, the third 6 times the amount of 60% ethanol extraction for 1 hour, combined alcohol extracts, recovered ethanol, concentrated to 1.20 clear paste, dried under reduced pressure, dried paste crushed, powder a.

[0143] Take 8 parts of Epimedium, add 10 times the amount of 50% ethanol to extract at 60°C for 2 hours, recover the ethanol, concentrate under reduced pressure to a thick paste with a relative density of 1.25-1.30, freeze-dry the c...

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Abstract

The invention relates to the technical field of medicine extraction, in particular to a traditional Chinese medicine composition for treating stroke, middle meridian, coronary heart disease and anginapectoris caused by obstruction of collaterals by blood stasis and a preparation method thereof. On the basis of compatibility of Shexiang Xinnaotong Jiaonang, effective parts of medicinal materials are enriched, separated and purified, components are screened, different extraction parts are re-compatible to form a new prescription, and the Chinese patent medicine with basically clear material basis, clear action mechanism and more accurate clinical indications is developed. It is shown by research by pharmacodynamic contrast, the effect of the traditional Chinese medicine composition is obviously superior to that of a control group; the traditional Chinese medicine composition can increase coronary blood flow, protect ischemic myocardial injury, adjust lipid peroxidation reaction, improvebrain tissue blood flow and neurotrophy and inhibit brain tissue apoptosis, has a definite pharmacological effect on stroke, middle and collateral channels, coronary heart disease, angina pectoris and the like caused by blood stasis blocking collaterals, and is remarkable in effect.

Description

technical field [0001] The invention relates to the technical field of medicine extraction, in particular to a traditional Chinese medicine composition for treating apoplexy, middle meridians, coronary heart disease and angina pectoris caused by blood stasis blocking collaterals and a preparation method thereof. Background technique [0002] With the improvement of people's living standards, the prevalence of various diseases that seriously threaten human life has been increasing year by year, among which the incidence of stroke and cardiovascular diseases has shown an obvious upward trend. Stroke has the characteristics of high incidence rate, high disability rate, high mortality rate and high recurrence rate, and is one of the main diseases causing death and disability in middle-aged and elderly people. There are 1.5 million to 1.8 million new stroke patients in my country every year, among which ischemic stroke patients account for about 43% to 65%, and some reports even ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/9066A61K9/20A61P9/10A61K31/045A61K35/55A61K35/62
CPCA61K9/2018A61K31/045A61K35/55A61K35/62A61K36/236A61K36/258A61K36/286A61K36/296A61K36/488A61K36/537A61K36/736A61K36/9066A61K2236/331A61K2236/333A61P9/10A61K2300/00
Inventor 杨喆茗许艳茹徐建赵伯友王鑫孙巍张颖李双
Owner 吉林修正药业新药开发有限公司
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