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Traditional Chinese medicine composition for treating stroke, its preparation method, pharmaceutical preparation and application

A technology of pharmaceutical preparations and compositions, which is applied in the field of traditional Chinese medicine compositions for treating stroke and its preparation, can solve the problems of heavy medical care, economic and social burdens, large doses taken by patients, and harm to patients' health, and achieve convenient Chinese medicine varieties, chemical The effect of clear ingredients and controllable quality

Active Publication Date: 2018-03-13
和光中药科技(天津)有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

According to the results of the third sampling survey on causes of death among Chinese residents released in 2008, stroke has become the number one cause of death among Chinese nationals, with a death rate 4-5 times higher than that in European and American countries, and the vast majority of stroke survivors will have hemiplegia , aphasia and even blindness and other serious sequelae, which seriously endanger the health of patients and affect their quality of life, and also bring heavy medical, economic and social burdens to patients' families and society
[0006] A Chinese patent CN1507910A discloses a pharmaceutical composition for the treatment of stroke. The active ingredients of the pharmaceutical composition are made of pangolin and Acanthopanax. It adopts the traditional extraction method, and the ointment rate is high, but the patient takes a large dose.

Method used

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  • Traditional Chinese medicine composition for treating stroke, its preparation method, pharmaceutical preparation and application
  • Traditional Chinese medicine composition for treating stroke, its preparation method, pharmaceutical preparation and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0049]Take 10kg of pangosaurus, crush it into a coarse powder, add 100L of 70% v / v ethanol to extract three times, each time for 2 hours, combine the extracts, concentrate under reduced pressure to a relative density of 1.03-1.08 (60°C), add water to dilute to the concentration of the sample solution 2g / mL (based on crude drug amount), adsorbed with 10L D101 macroporous resin (resin diameter-to-height ratio 1:8), adsorption flow rate 2BV / h, first eluted with 5BV water, then 50%v / v ethanol 5BV, The elution flow rate is 2BV / h, the 50% v / v ethanol eluate is collected, the ethanol is recovered, and dried under reduced pressure to obtain 500 g of the effective part of Pangosaurus. It contains 260g of pangolin total saponins.

[0050] Take another 5kg of Acanthopanax, crush it into coarse powder, add 35L of 75% v / v ethanol, reflux extraction 3 times, each time for 4 hours, filter, combine the filtrates, recover ethanol, and concentrate under reduced pressure to a relative density o...

Embodiment 2

[0054] Take 10kg of the herb, crush it into a coarse powder, add 80L of 30% v / v ethanol to reflux and extract three times, each time for 1 hour, filter, combine the extracts, recover the solvent, concentrate until there is no alcohol smell, dilute with water to 20L, centrifuge, and pour The supernatant was diluted with water to a concentration of 1 g / mL (calculated as the amount of crude drug), adsorbed with 10LHPD100 macroporous resin (resin diameter-to-height ratio 1:4), and the adsorption flow rate was 1BV / h. Elution with v / v ethanol 4BV, elution flow rate 4BV / h, collect 70% v / v ethanol eluate, recover ethanol, spray dry, and obtain 470g of effective parts of pangolinus. It contains 280g of pangolin total saponins.

[0055] Take another 6kg of Acanthopanax, crush it into coarse powder, add 30L of 50% v / v ethanol, cold soak and extract three times, 24 hours each time, combine the extracts, recover the solvent, concentrate under reduced pressure until no alcohol smell, add wa...

Embodiment 3

[0059] Take 8kg of pangosaurus, crush it into a coarse powder, add 80L50%v / v ethanol for cold extraction three times, 24h each time, filter, combine the three extracts, recover the solvent, concentrate until there is no alcohol smell, add water to dilute to the concentration of the sample solution 1.5g / mL (based on crude drug amount), adsorbed with 5LNKA-9 macroporous resin (resin diameter-to-height ratio 1:15), adsorption flow rate 5BV / h, first eluted with 4BV of water, and then eluted with 8BV of 60%v / v ethanol , the elution flow rate was 1BV / h, the 60% v / v ethanol eluate was collected, concentrated, and freeze-dried to obtain 320g of the effective part of Pangosaurus. It contains 231g of pangolin total saponins.

[0060] Another 10kg of Acanthopanax senticosus was crushed into coarse powder, decocted in 100L water three times, 2 hours each time, filtered, combined three times, recovered solvent, concentrated to relative density 1.2 (60°C), added ethanol to make it contain ...

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Abstract

The present invention provides a traditional Chinese medicine composition for treating stroke. The traditional Chinese medicine composition includes effective parts of Pangolinia and Acanthopanax effective parts as active ingredients, wherein, the total saponins of Pangolinus contained in the effective parts of Pangosia and the The sum of the total flavonoids of Acanthopanax senticosus contained in the effective part of Acanthopanax accounts for 50-90% w / w of the traditional Chinese medicine composition. The present invention also provides a method for preparing the above-mentioned Chinese medicine composition, a pharmaceutical preparation containing the Chinese medicine composition, and the use of the above-mentioned Chinese medicine composition or pharmaceutical preparation in the preparation of medicines for the treatment of stroke (cerebral infarction) convalescent Qi-deficiency and blood-stasis syndrome application. The results of pharmacological experiments show that the traditional Chinese medicine composition has a good effect on cerebral ischemia protection and promoting blood circulation and removing blood stasis, and the material basis is more clear, the chemical composition is clearer, the quality is more controllable, the dosage is reduced, and it is convenient to take, which is in line with traditional Chinese medicine. It meets the requirements of modernization and has a good development prospect.

Description

technical field [0001] The invention belongs to the technical field of medicine, and relates to a traditional Chinese medicine composition for treating apoplexy, a preparation method, a pharmaceutical preparation and application thereof. Background technique [0002] Stroke is one of the major diseases that threaten human life and health in today's society. The number of stroke deaths in developing countries is twice that of developed countries. 1 / 3 of stroke patients die within six months of onset, 90% of survivors have sequelae of varying degrees, and half of them lose the serious sequelae of self-care and work ability; 1 / 3 of stroke patients relapse within 3-5 years seizures until death. Due to the high morbidity rate, high mortality rate, high disability rate, high recurrence rate and many complications of this disease, the medical community listed it as one of the three major diseases threatening human health along with coronary heart disease and cancer. At present, t...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/8945A61P9/10
Inventor 孙卫郑雅楠廖茂梁张铁军
Owner 和光中药科技(天津)有限公司
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