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Application of composition in preparation of medicines for preventing and treating constipation

A technology of composition and use, applied in the field of medicine, can solve problems such as increased endorphin transmitters, increased pain in patients, and life-threatening problems, and achieve the effects of shortening defecation time, significant curative effect, and increasing defecation frequency

Pending Publication Date: 2020-06-09
LUNAN PHARMA GROUP CORPORATION
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

First of all, because patients with constipation cannot eliminate endotoxins in time, endorphin transmitters will increase, which will increase the pain of patients; in addition, long-term constipation will paralyze the intestinal tract, causing severe intestinal obstruction and life-threatening, so timely and effective It is especially important to treat constipation
But existing medicines for treating constipation all have different degrees of shortcomings, and there are various side effects. How to find an efficient and healthy medicine for treating constipation can reduce the side effects of constipation caused by opioids and improve the quality of life of cancer patients. especially important

Method used

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  • Application of composition in preparation of medicines for preventing and treating constipation
  • Application of composition in preparation of medicines for preventing and treating constipation
  • Application of composition in preparation of medicines for preventing and treating constipation

Examples

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Embodiment Construction

[0026] In order for those skilled in the art to fully understand the present invention, the present invention is further described through specific examples below, but those skilled in the art should know that the present invention is not limited in any way by the examples of the present invention.

[0027] Example of efficacy

[0028] 1. Mouse Small Intestine Propulsion Test

[0029] Take 60 healthy ICR mice, half male and half female, weighing 18-22 g, and randomly divide them into 5 groups, 12 mice in each group, which are normal control group, model control group, Shouhui laxative composition group, lactulose group, composition group.

[0030] After the mice were fasted for 12 hours, each administration group except the normal control group was intragastrically given loperamide hydrochloride (3.0 mg / kg), and the normal control group was given corresponding volume of distilled water. After 30 minutes, each administration group was given the corresponding dose of medicine ...

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Abstract

The invention belongs to the field of medicine, and relates to medical application of a composition. In order to solve the problem of constipation caused by taking an analgesic by a cancer patient, the invention provides the application of the composition in preparation of medicines for preventing and treating constipation. Mouse small intestine propulsion test results of pharmacodynamic embodiments show that the composition provided by the invention can significantly improve the small intestine carbon juice propulsion rate of mice; and mouse defecation test results show that the composition provided by the invention can significantly shorten the first defecation time of mice and increase the defecation times. Clinical results show that the effective components in the composition can playa significant synergistic effect, can significantly reduce the recurrence rate, and has important significance in solving the constipation problem of cancer patients.

Description

technical field [0001] The invention belongs to the field of medicine and relates to the medical use of a composition, in particular to the use of a composition in preparing medicines for preventing and treating constipation. Background technique [0002] Constipation is one of the most common chronic gastrointestinal symptoms clinically. The incidence rate in my country is about 10% to 15%. At present, the number of constipation has exceeded 130 million. Domestic constipation survey data show that the incidence of constipation is related to factors such as age, gender, region, occupation, and education level. With the improvement of people's living standards and changes in eating habits, the age of constipation patients is gradually becoming younger, and the incidence of constipation in cities is much higher than that in rural areas. Research data show that aging is a high incidence factor of constipation, and the number of patients with constipation increases significantl...

Claims

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Application Information

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IPC IPC(8): A61K36/896A61K36/886A61K31/7016A61P1/10A61K35/36
CPCA61K36/704A61K36/896A61K36/886A61K36/482A61K36/815A61K35/36A61K36/258A61K36/284A61K36/752A61K31/7016A61P1/10A61K2300/00
Inventor 孙成磊宋毅谭丽萍
Owner LUNAN PHARMA GROUP CORPORATION
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