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Grape skin for use in treatment of dysbiosis

A technology of dysbiosis and grape skin, applied in the direction of microbial determination/inspection, biochemical equipment and methods, and resistance to vector-borne diseases, etc. It can solve the problems that Faecalibacterium prausnitzii strains cannot grow citrus pectin

Active Publication Date: 2020-06-05
GOODGUT SL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Lopez-Siles M. et al. (Appl.Environ.Microbiol.2012,78(2):420) disclosed the discovery that F. prausnitzii uses apple pectin as a substrate, but none of the tested F. Grown in citrus pectin (see graph in Table 2 on page 424)

Method used

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  • Grape skin for use in treatment of dysbiosis
  • Grape skin for use in treatment of dysbiosis
  • Grape skin for use in treatment of dysbiosis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0217] Example 1.- Characterization of the determined dehydrated grape skin composition

[0218] The dehydrated grape skin composition was obtained by a method comprising drying a white grape variety from the grape species Vitis vinifera (i.e. Grenache Blanc (Aren Empordà, Catalan , Spain)) for 2 days, then ground and sieved using a 1 mm sieve, the resultant composition having a particle size of 1 mm or less is referred to herein as "Previpect TM ".

[0219] The following table provides the results of the analysis of the chemical composition of this grape skin component, for example, indicating the content of soluble and insoluble fibers and neutral sugars:

[0220] Chemical composition analysis:

[0221] result:

[0222] Total sugar (expressed as glucose) % (p / p) s.s.n 53.24

[0223] Method: Lurff-Schoorl volumetric method (regulation (EC) n°152 / 2009)

[0224] Sugar chromatogram

[0225] Method: HPLC Refractive Index (RI)

[0226]

[0227] Soluble and insoluble di...

Embodiment 2

[0241] Example 2.-Previpect TM In vitro incubation with stool samples from IBD patients and healthy subjects

[0242] Materials and Methods

[0243] 1. Patients, Clinical Data and Sampling

[0244] From 13 healthy subjects (H) and 11 patients diagnosed with inflammatory bowel disease (IBD), 5 of whom were diagnosed with Crohn's disease (CD), 6 with ulcerative colitis (UC )) Fecal samples were obtained. The volunteers were recruited by the Gastroenterology Service of Dr. Josep Trueta University Hospital (Girona, Spain).

[0245] Subjects recruited as IBD patients had been diagnosed according to standard clinical, pathological and endoscopic criteria, and all patients had active disease in terms of inflammatory response (calprotectin level over 250 μg / G or protein C response (PCR ) level exceeds 0.5μg / L). A control group consisting of healthy subjects without any known gastrointestinal disease was recruited according to clinical criteria.

[0246] 2. Sample collection,...

Embodiment 3

[0310] Example 3.-Previpect TM In vitro incubation with stool samples from IBS patients and healthy subjects

[0311] Materials and Methods

[0312] 1. Patients, Clinical Data and Sampling

[0313] Fecal samples were obtained from 3 healthy subjects (H) and 3 patients diagnosed with irritable bowel syndrome (IBS). The volunteers were recruited by the Gastroenterology Service of Dr. Josep Trueta University Hospital (Girona, Spain).

[0314] Subjects recruited as IBS patients were diagnosed according to the Rome IV criteria for IBS: Abdominal pain on average at least 1 day per week during the past 3 months with two or more of the following kind:

[0315] (1) related to defecation

[0316] (2) Related to changes in frequent stools

[0317] (3) Associated with a change in stool morphology (consistency); and

[0318] Symptoms must have started at least 6 months ago (Lacy et al., Gastroenterology 2016, 150(6), 1393-1407).

[0319] A control group consisting of healthy su...

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Abstract

The present invention relates to the use of grape skin or a composition comprising it as prebiotic for increasing the intestinal levels and / or activity of butyrate-producing bacteria, such as Faecalibacterium prausnitzii, F. prausnitzii phylogroup I (PHGI), F. prausnitzii phylogroup II (PHGII), Roseburia hominis and Subdoligranulum variabile, in a subject. More specifically it refers to grape skinor a composition comprising it for use in a method of treating intestinal dysbiosis in a subject, wherein intestinal dysbiosis is characterized by a decrease of butyrate- producing bacteria levels and / or activity. In addition, it pertains to grape skin or a composition comprising it for use in a method of treating an inflammatory or non-inflammatory intestinal disease in a subject having reducedlevels and / or reduced activity of butyrate-producing bacteria.

Description

technical field [0001] The present invention relates to the fields of therapy and nutraceuticals, in particular the present invention relates to grape skins or compositions comprising grape skins as prebiotics for increasing butyrate producing bacteria (e.g. Faecalibacterium prausnitzii, Faecalibacterium prausnitzii) in a subject Use in Lineage Genetic I (PHGI), Faecalibacterium prausnitzii Lineage II (PHGII), Roseburia hominis and Subdoligranulum variabile). [0002] More specifically, the present invention relates to grape skins or compositions comprising grape skins for use in a method of treating intestinal dysbiosis in a subject, wherein the intestinal dysbiosis is characterized by reduced levels and / or reduced activity of butyrate-producing bacteria. Additionally, the present invention relates to grape skins or compositions comprising grape skins for use in the treatment of inflammatory or non-inflammatory conditions in a subject having reduced levels and / or reduced acti...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/87A61P1/00
CPCA61K36/87A61P1/00A61P1/04A23L33/105A61K35/37A61K35/38C12Q1/689
Inventor 泽维尔·奥尔迪格·曼特利夫拉多·耶素斯·加西亚-吉尔马里奥娜·萨拉·佩吉斯
Owner GOODGUT SL
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