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Anti-adhesion polyformaldehyde ligating hemostatic clamp and preparation method and application thereof

A technology of polyoxymethylene and hemostatic clips, which is applied in the field of biomedical engineering, can solve the problems of postoperative adhesions, avoid tissue adhesions, facilitate clinical promotion, and ensure the effect of ligation

Active Publication Date: 2020-06-05
NANTONG UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, after using these products in clinical laparoscopic cholecystectomy, it was found that there were more serious postoperative adhesions

Method used

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Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0021] The invention provides a kind of preparation method of anti-adhesion polyoxymethylene ligation hemostatic clip, comprises the following steps:

[0022] 1) Put the polyformaldehyde ligation hemostatic clip into the ethanol solution, ultrasonically clean to remove surface impurities, dry, and then use a linear dielectric barrier discharge plasma device for surface activation treatment;

[0023] 2) Chitosan and carboxymethyl chitosan are added into organic weak acid to prepare a mixed solution, the total concentration of chitosan and carboxymethyl chitosan in the mixed solution is 1 to 3 wt%, wherein the chitosan The mass ratio of carboxymethyl chitosan is 1:9~9:1;

[0024] 3) Immerse the polyoxymethylene ligation hemostatic clip after the surface activation treatment in step 1) in the mixed solution for 30 minutes, take it out and dry it under vacuum at 40°C, then immerse it in the sodium hydroxide solution for 2 hours, take it out and wash it with deionized water until ...

Embodiment 1

[0032](1) Surface activation treatment: put the polyformaldehyde ligation hemostatic clip into 95wt% ethanol, ultrasonically clean to remove surface impurities, then put it into a vacuum oven, after drying, carry out surface activation treatment with a narrow and long plasma device, and the treatment voltage is 220v, the processing power is 300w, the processing time is 300s, and the processing atmosphere is oxygen.

[0033] (2) Composite 18g chitosan and 2g carboxymethyl chitosan and add 980g concentration of 2wt% lactic acid solution to prepare 1000g mixed solution.

[0034] (3) Anti-adhesion treatment: immerse the polyoxymethylene ligation hemostatic clip after the surface activation treatment in the mixed solution for 30 minutes, take it out from the solution, dry it under vacuum at 40°C, and then immerse it in a sodium hydroxide solution with a mass concentration of 5%. After 2 hours, it was taken out and washed with deionized water for 12 hours, washed to neutrality and t...

Embodiment 2

[0036] (1) Surface activation treatment: put the polyformaldehyde ligation hemostatic clip into 95wt% ethanol, ultrasonically clean to remove surface impurities, then put it into a vacuum oven, after drying, carry out surface activation treatment with a narrow and long plasma device, and the treatment voltage is 150v, the processing power is 250w, the processing time is 50s, and the processing atmosphere is vacuum.

[0037] (2) Composite 18g chitosan and 12g carboxymethyl chitosan and add 970g concentration of 2wt% lactic acid solution to prepare 1000g mixed solution.

[0038] (3) Anti-adhesion treatment: immerse the polyoxymethylene ligation hemostatic clip after the surface activation treatment in the mixed solution for 30 minutes, take it out from the solution, dry it under vacuum at 40°C, and then immerse it in a sodium hydroxide solution with a mass concentration of 5%. After 2 hours, it was taken out and washed with deionized water for 12 hours, washed to neutrality and ...

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PUM

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Abstract

The invention relates to the field of biomedical engineering, and discloses an anti-adhesion polyformaldehyde ligation hemostatic clamp and a preparation method and application thereof. A linear dielectric barrier discharge plasma device is adopted to treat the polyformaldehyde ligation hemostatic clamp, so that an active group and a special threaded rough microstructure are generated on the surface of the polyformaldehyde ligation hemostatic clamp, and then the polyformaldehyde ligating hemostatic clamp subjected to surface activation treatment is soaked in a mixed solution containing chitosan and carboxymethyl chitosan, so that the chitosan and the carboxymethyl chitosan are uniformly and firmly distributed on the surface of the hemostatic clamp to form a composite anti-adhesion membrane. According to the anti-adhesion polyformaldehyde ligating hemostatic clamp, the effect of avoiding tissue adhesion after an operation while the ligating effect is guaranteed is achieved, and the degradation time of the composite anti-adhesion membrane can be controlled by adjusting the compounding ratio of chitosan to carboxymethyl chitosan so as to adapt to the tissue repair time. The anti-adhesion polyformaldehyde ligating hemostatic clamp has a good clinical use effect and is easy to promote clinically.

Description

technical field [0001] The invention relates to the field of biomedical engineering, in particular to an anti-adhesion polyoxymethylene ligation hemostatic clip and a preparation method and application thereof. Background technique [0002] Avoiding postoperative bile leakage and bleeding is the key link in laparoscopic cholecystectomy, so it is particularly important to use firm and reliable hemostatic clips for ligation of the cystic duct and cystic artery to avoid and prevent postoperative complications. At present, titanium clips are the most widely used in laparoscopic cholecystectomy. Although titanium clips are cheap and easy to operate, it has recently been found that titanium clips may fall off or shift into the bile duct due to incomplete clipping, causing cholangitis, Obstruction or stone formation. At the same time, the titanium clip is conductive, and if the coagulator touches it, it will cause tissue burns and interfere with imaging examinations. [0003] In ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08J7/12A61L31/06A61L31/10A61L31/14C08L59/00
CPCC08J7/123C08J7/12A61L31/06A61L31/10A61L31/14A61L31/148A61L2400/18C08J2359/00C08L59/00C08L5/08C08L1/28
Inventor 杨宇民李鹏张伟凌珏张鲁中李贵才赵亚红杨鹏翔
Owner NANTONG UNIVERSITY
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