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An anti-adhesion polyoxymethylene ligation hemostatic clip and its preparation method and application

A polyoxymethylene and hemostatic clip technology, which is applied in the field of biomedical engineering, can solve problems such as postoperative adhesion, and achieve the effects of avoiding tissue adhesion, facilitating clinical promotion, and ensuring the effect of ligation.

Active Publication Date: 2022-04-01
NANTONG UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, after using these products in clinical laparoscopic cholecystectomy, it was found that there were more serious postoperative adhesions

Method used

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  • An anti-adhesion polyoxymethylene ligation hemostatic clip and its preparation method and application
  • An anti-adhesion polyoxymethylene ligation hemostatic clip and its preparation method and application

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preparation example Construction

[0020] The invention provides a kind of preparation method of anti-adhesion polyoxymethylene ligation hemostatic clip, comprises the following steps:

[0021] 1) Put the polyformaldehyde ligation hemostatic clip into the ethanol solution, ultrasonically clean to remove surface impurities, dry, and then use a linear dielectric barrier discharge plasma device for surface activation treatment;

[0022] 2) Chitosan and carboxymethyl chitosan are added into organic weak acid to prepare a mixed solution, the total concentration of chitosan and carboxymethyl chitosan in the mixed solution is 1 to 3 wt%, wherein the chitosan The mass ratio of carboxymethyl chitosan is 1:9~9:1;

[0023] 3) Immerse the polyoxymethylene ligation hemostatic clip after the surface activation treatment in step 1) in the mixed solution for 30 minutes, take it out and dry it under vacuum at 40°C, then immerse it in the sodium hydroxide solution for 2 hours, take it out and wash it with deionized water until ...

Embodiment 1

[0030] (1) Surface activation treatment: put the polyformaldehyde ligation hemostatic clip into 95wt% ethanol, ultrasonically clean to remove surface impurities, then put it into a vacuum oven, after drying, carry out surface activation treatment with a narrow and long plasma device, and the treatment voltage is 220v, the processing power is 300w, the processing time is 300s, and the processing atmosphere is oxygen.

[0031](2) Composite 18g chitosan and 2g carboxymethyl chitosan and add 980g concentration of 2wt% lactic acid solution to prepare 1000g mixed solution.

[0032] (3) Anti-adhesion treatment: immerse the polyoxymethylene ligation hemostatic clip after the surface activation treatment in the mixed solution for 30 minutes, take it out from the solution, dry it under vacuum at 40°C, and then immerse it in a sodium hydroxide solution with a mass concentration of 5%. After 2 hours, it was taken out and washed with deionized water for 12 hours, washed to neutrality and t...

Embodiment 2

[0034] (1) Surface activation treatment: put the polyformaldehyde ligation hemostatic clip into 95wt% ethanol, ultrasonically clean to remove surface impurities, then put it into a vacuum oven, after drying, carry out surface activation treatment with a narrow and long plasma device, and the treatment voltage is 150v, the processing power is 250w, the processing time is 50s, and the processing atmosphere is vacuum.

[0035] (2) Composite 18g chitosan and 12g carboxymethyl chitosan and add 970g concentration of 2wt% lactic acid solution to prepare 1000g mixed solution.

[0036] (3) Anti-adhesion treatment: immerse the polyoxymethylene ligation hemostatic clip after the surface activation treatment in the mixed solution for 30 minutes, take it out from the solution, dry it under vacuum at 40°C, and then immerse it in a sodium hydroxide solution with a mass concentration of 5%. After 2 hours, it was taken out and washed with deionized water for 12 hours, washed to neutrality and ...

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Abstract

The invention relates to the field of biomedical engineering, and discloses an anti-adhesion polyoxymethylene ligation hemostatic clip and a preparation method and application thereof. The present invention uses a linear dielectric barrier discharge plasma device to process the polyoxymethylene ligation hemostatic clip, and then generates on the surface of the hemostatic clip. Active radicals and a special thread-like micro-rough structure; then the surface-activated polyoxymethylene ligation hemostatic clip is immersed in a mixed solution containing chitosan and carboxymethyl chitosan, so that chitosan and carboxymethyl Chitosan is evenly and firmly distributed on the surface of the hemostatic clip to form a composite anti-adhesion film. The anti-adhesion polyformaldehyde ligation hemostatic clip of the present invention achieves the effect of avoiding tissue adhesion after surgery while ensuring the ligation effect, and the degradation time of the composite anti-adhesion film of the present invention can be adjusted by adjusting chitosan and carboxymethyl chitosan Compound ratio to control the length to accommodate tissue repair time. The anti-adhesion polyoxymethylene ligation hemostatic clip of the invention has good clinical application effect and is easy to clinical promotion.

Description

technical field [0001] The invention relates to the field of biomedical engineering, in particular to an anti-adhesion polyoxymethylene ligation hemostatic clip and a preparation method and application thereof. Background technique [0002] Avoiding postoperative bile leakage and bleeding is the key link in laparoscopic cholecystectomy, so it is particularly important to use firm and reliable hemostatic clips for ligation of the cystic duct and cystic artery to avoid and prevent postoperative complications. At present, titanium clips are the most widely used in laparoscopic cholecystectomy. Although titanium clips are cheap and easy to operate, it has recently been found that titanium clips may fall off or shift into the bile duct due to incomplete clipping, causing cholangitis, Obstruction or stone formation. At the same time, the titanium clip is conductive, and if the coagulator touches it, it will cause tissue burns and interfere with imaging examinations. [0003] In ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08J7/12A61L31/06A61L31/10A61L31/14C08L59/00
CPCC08J7/123C08J7/12A61L31/06A61L31/10A61L31/14A61L31/148A61L2400/18C08J2359/00C08L59/00C08L5/08C08L1/28
Inventor 杨宇民李鹏张伟凌珏张鲁中李贵才赵亚红杨鹏翔
Owner NANTONG UNIVERSITY
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