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Self-assembled amino acid derivative functionalized magnetic-carbon nanotube composite material and its preparation method and application

A composite material and carbon nanotube technology, which is used in the preparation of cyanide reaction, chemical instruments and methods, preparation of organic compounds, etc., can solve the problems of limited application scope, difficult solid-liquid separation, etc., and achieves increased load capacity and difficult separation. , to achieve the effect of controllable design

Active Publication Date: 2022-02-08
TIANJIN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

The research on nanomaterials in the field of chiral recognition has gained more and more attention, but most nanomaterials are difficult to achieve solid-liquid separation in solution, which greatly limits their application range.

Method used

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  • Self-assembled amino acid derivative functionalized magnetic-carbon nanotube composite material and its preparation method and application
  • Self-assembled amino acid derivative functionalized magnetic-carbon nanotube composite material and its preparation method and application
  • Self-assembled amino acid derivative functionalized magnetic-carbon nanotube composite material and its preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Example 1—Preparation method of self-assembled hexadecyl-L hydroxyproline functionalized magnetic-carbon nanotube composite material

[0026] (1) Magnetic Fe 3 o 4 Preparation of / MWCNTs composites

[0027] Weigh 1.35g FeCl 3 ·6H 2 O was added to 35 mL of ethylene glycol solution. Then, 3.6 g of anhydrous sodium acetate, 1.0 g of polyethylene glycol and 0.2 g of carboxylated multi-walled carbon nanotubes were sequentially added, and ultrasonically dispersed for 0.5 h. Add 6 mL of hexamethylenediamine, continue mechanical stirring for 0.5 h, then transfer the liquid to a sealed stainless steel hydrothermal reaction kettle with a polytetrafluoroethylene liner, and heat to 220 ° C for 8 h. The obtained product was washed 6 times with deionized water and absolute ethanol, and dried under vacuum at 80 °C to prepare magnetic Fe 3 o 4 / MWCNTs composites.

[0028] (2) Preparation of self-assembled amino acid derivative functionalized magnetic-carbon nanotube composites ...

Embodiment 2

[0031] Embodiment 2—Structural characterization of magnetic materials

[0032] (1) Shape and size characterization

[0033] The particle size and morphology of the prepared magnetic particles were observed with a Tecnai G2F20 transmission electron microscope (FEI, USA). figure 1 is magnetic Fe 3 o 4 Nanoparticles and Magnetic Fe 3 o 4 / MWCNTs-Hyp composite transmission electron micrographs. From figure 1 (a) It can be seen that the magnetic Fe without multi-walled carbon nanotubes 3 o 4 Nanoparticles are petal-like, with a particle size of 80±5nm; figure 1 (b) shows magnetic Fe 3 o 4 Magnetic Fe in / MWCNTs-Hyp composites 3 o 4 The nanoparticles are evenly deposited on the carbon nanotubes, with a particle size of 60±5nm. After the carbon nanotubes are added, the steric hindrance increases, resulting in restricted growth of crystal nuclei, making the magnetic Fe 3 o 4 The particle size of the nanoparticles is reduced.

[0034] (2) Crystal form characterization

...

Embodiment 3

[0040] Example 3—Self-assembled hexadecyl-L-hydroxyproline functionalized magnetic-carbon nanotube composite material for splitting amino acids

[0041] The self-assembled amino acid derivative functionalized magnetic-carbon nanotube composite material prepared by the technical scheme of the present invention is used to resolve amino acid chiral isomers. With magnetic Fe 3 o 4 / MWCNTs-Hyp composite material is used as a chiral adsorbent to resolve amino acid enantiomers in solution to test its chiral resolution ability, in which the functional group L-hydroxyproline is the chiral recognition agent Ligand. The chiral ligand coordinates with the D- and L-enantiomers of the amino acid respectively through the central metal ion to form a complex of two diastereoisomers, and the stability of the two complexes is different , thus achieving chiral separation.

[0042] DL-phenylalanine was selected as the analyte, and the resolution effect was analyzed by HPLC. Use acetonitrile-wat...

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Abstract

The invention discloses a self-assembled amino acid derivative functionalized magnetic-carbon nanotube composite material and its preparation method and application. The magnetic Fe is prepared by a one-step solvothermal reduction method. 3 o 4 ‑Multi-walled carbon nanotube composites utilizing magnetic Fe 3 o 4 Hydrophobic interaction of / MWCNTs composite material, N-hexadecyl-L-hydroxyproline self-assembled on the surface of carbon nanotubes to obtain a stable complex, this material was used as a chiral adsorbent to resolve amino acid enantiomers isomers to test their chiral resolution performance. The present invention uses magnetic nanomaterials as chiral selector carriers, combined with self-assembly technology as a fixed method to prepare chiral recognition materials, which is expected to improve the stability of the chiral stationary phase and the lack of loading capacity, and realize rapid screening of chiral selectors. Efficient, high-capacity chiral separations.

Description

technical field [0001] The invention belongs to the technical field of functional materials and chiral separation, and more specifically relates to a self-assembled amino acid derivative functionalized magnetic-carbon nanotube composite material and its preparation method and application in chiral separation. Background technique [0002] The two enantiomers of chiral compounds have the same physical and chemical properties except optical activity, but their biochemical and pharmacological activities are often different, or even have opposite effects. Therefore, the study of chiral separation technology is of great significance to the pharmaceutical industry and life science. Chiral resolution technology mainly includes mechanical resolution, preferential crystallization, chemical resolution, enzymatic resolution, membrane separation and chromatographic resolution and other resolution methods. Among them, the liquid chromatography chiral stationary phase resolution method i...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): B01J20/29B01J20/28B01J20/30C07C227/34C07C229/36G01N30/74
CPCB01J20/29B01J20/28009C07C227/34G01N30/74C07C229/36
Inventor 邓小娟李文斌
Owner TIANJIN UNIV
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