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Application of TIL (tumor infiltrating lymphocyte) immunization therapy to improvement of colorectal cancer

A colorectal cancer, immunotherapy technology, applied in the field of immune cell therapy, can solve problems such as causality disputes, and achieve the effect of small side effects and strong specificity

Inactive Publication Date: 2020-06-05
卡替(上海)细胞生物技术有限公司
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

(3) In China, cases of schistosomiasis complicated by colon cancer are not uncommon, but the causality is still debated

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  • Application of TIL (tumor infiltrating lymphocyte) immunization therapy to improvement of colorectal cancer

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Embodiment Construction

[0017] The present invention will be described in detail below in conjunction with specific embodiments.

[0018] The invention discloses an application of TIL immunotherapy in improving colorectal cancer. The application specifically includes the following steps: the colorectal cancer patient undergoes surgery, and the excised tumor tissue is sent to a GMP laboratory for subsequent processing and cultivation; After 3 to 4 weeks, the TIL cells were cultured and matured, and then transported back to the hospital for reinfusion to the patient. The average amount of TIL cells per injection was 1.48×10 11 After reinfusion of TIL cells, receive 2-3 courses of intravenous injection of interleukin 2, each time 200,000-300,000 units / kg.

[0019] As a preferred embodiment of the present invention, after the reinfusion of TIL cells, receive 2 courses of intravenous injection of interleukin 2, each time 250,000 units / kg.

[0020] As the best embodiment of the present invention, colorect...

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Abstract

The invention discloses an application of TIL (tumor infiltrating lymphocyte) immunization therapy to improvement of colorectal cancer. The application specifically comprises following steps: a patient with colorectal cancer undergoes a surgery, and tumor tissue which is cut off is sent to a GMP laboratory and subjected to subsequent treatment and culture; after 3-4 weeks, TIL cells are mature after culture and then are transported to the hospital to be transfused back to the patient, and the average quantity of the injected TIL cells is 1.48*10<11> each time; after the TIL cells are transfused back to the patient, the patient undergoes interleukin 2 injection for 2-3 course of treatment, and the quantity of the interleukin 2 injection is 0.2-0.3 million units / kg each time. Seven tumors inthe body of one 49-year-old patient who has lung metastatic colorectal cancer and undergoes chemotherapy and radiotherapy treatment continue to shrink after 9 months. The TIL immunization therapy hashigh efficiency when used for improving colorectal cancer, the curative effect of the TIL is 50-100 times that of LAK, and the TIL can specifically recognize the capacity of tumors producing neoantigens.

Description

technical field [0001] The invention belongs to the technical field of immune cell therapy, and in particular relates to an application of TIL immunotherapy in improving colorectal cancer. Background technique [0002] Colorectal cancer is a common malignant tumor in the gastrointestinal tract. Early symptoms are not obvious. As the tumor grows, symptoms such as changes in bowel habits, blood in the stool, diarrhea, alternating diarrhea and constipation, and local abdominal pain appear. In the late stage, anemia, Systemic symptoms such as weight loss. Its morbidity and mortality are second only to gastric cancer, esophageal cancer and primary liver cancer among digestive system malignant tumors. China is a low-incidence area of ​​colorectal cancer in the world, but the incidence rate in many areas has a tendency to increase to varying degrees. The disease mostly occurs in men over middle age, most common in 40-70 years old, but it is not uncommon to find people under 30 ye...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K35/17A61K38/20A61P35/00
CPCA61K35/17A61K38/2013A61P35/00A61K2300/00
Inventor 李军
Owner 卡替(上海)细胞生物技术有限公司
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