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Zinc composition for oral care

A composition and oral technology, applied in the field of oral care, can solve problems such as tooth loss and alveolar bone loss

Inactive Publication Date: 2020-06-02
COLGATE PALMOLIVE CO
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Periodontitis can lead to loss of alveolar bone and, if left untreated, eventual tooth loss

Method used

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  • Zinc composition for oral care
  • Zinc composition for oral care

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Experimental program
Comparison scheme
Effect test

Embodiment

[0062] Cell preparation:

[0063] Human periodontal ligament fibroblasts (HPdLF, Lonza Cat. , #CC-3205) at 37°C in 5% CO 2 Incubate overnight.

[0064] Preparation of bacteria:

[0065] Incubate the pathogenic bacteria (Actinobacterium actinomyces (Aa) ATCC cat. no. 29522 or Porphyromonas gingivalis (Pg) ATCC cat. no. 33277) at 37 °C overnight (A. , and P. gingivalis with half-strength brain heart infusion (supplemented with yeast extract, hemin, and vitK1)). Read the optical density (OD) at 610 nm. Bacteria were centrifuged at 8000 rpm for 10 min and the pellet was resuspended in cell culture medium and diluted to an OD of 0.1 to 0.2 610 .

[0066] Cell infection:

[0067] Test samples (dissolved in water) were added to the cells and incubated at 37C in 5% CO before adding bacteria 2 Incubate for 30 minutes in the incubator. By adding the resuspended bacteria to the cells and incubating at 37 °C in 5% CO 2 Incubate the cells for an additional 90 to 120 minutes in the ...

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Abstract

The invention relates to a zinc composition for oral care, and provides a composition containing a zinc ion source. The composition containing the zinc ion source is used for inhibiting periodontal pathogens from being attached to oral soft tissue, such as gingival epithelial cells, or invading the oral soft tissue, such as the gingival epithelial cells.

Description

[0001] This application is a divisional application of a Chinese patent application with an application date of December 2, 2013, an application number of 201380081309.1, and an invention title of "Zinc Composition for Oral Care". technical field [0002] The present invention relates to the field of oral care. Background technique [0003] Periodontal disease is a chronic bacterial infection that affects the gum tissue, periodontal ligament, cementum, and alveolar bone. Diseases such as gingivitis and periodontitis are complex, multifactorial and multistage disorders involving the interaction of bacteria and host cells. Gingivitis (inflammation of the gums or gums) can lead to periodontitis (inflammation of the periodontal tissue) if left untreated. Bacteria present in the plaque cause an inflammatory and / or immune response that can ultimately lead to the destruction of bone and gum tissue. Periodontitis can lead to loss of alveolar bone and, if left untreated, eventual t...

Claims

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Application Information

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IPC IPC(8): A61K8/365A61K8/27A61Q11/00A61Q17/00A61P1/02A61P31/04A61P31/02
CPCA61K8/365A61Q11/00A61K8/27A61P1/02
Inventor 杨英哈什·M·特里维迪许国锋
Owner COLGATE PALMOLIVE CO
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