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Composition for preventing hair loss or promoting hair growth

A hair growth and hair loss technology, applied in the direction of drug combination, hair care, non-active ingredients of polymer compounds, etc., can solve the problems of toxicity, side effects, and insufficiency

Pending Publication Date: 2020-05-01
CK BIOTECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although various types of hair growth assistance techniques are commonly used to promote blood circulation in the scalp and provide nutrition to the hair, they are often toxic and have side effects that are not effective enough

Method used

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  • Composition for preventing hair loss or promoting hair growth
  • Composition for preventing hair loss or promoting hair growth
  • Composition for preventing hair loss or promoting hair growth

Examples

Experimental program
Comparison scheme
Effect test

preparation Embodiment 1

[0187] Preparation Example 1. Synthesis of 5-methoxy indirubin-3'-oxime (A3334)

[0188] ①Synthesis of intermediate product 5'-methoxy-[2,3'-biindolineylidene]-2',3-dione

[0189]

[0190] 5-Methoxyisatin (1000mg, 5.65mmol) was added to a 250ml round bottom flask and dissolved in methanol (225ml), then indole acetate (989mg, 5.65mmol) and sodium carbonate (Na 2 CO 3 ) (1496 mg, 14.11 mmol), and the mixture was stirred at 65° C. for 12 hours. The reaction was quenched by TLC (Rf = 0.4, ethyl acetate / hexane = 1 / 2 (vol / vol)), and the product was cooled on ice until massive crystals formed. After crystals were formed and the solvent was removed by filtration, the filtrate was discarded, and the product was washed several times with solvent (ethanol / water=1 / 1 (vol / vol)). The product was filtered, dried in a vacuum pump and used in the next step without further purification.

[0191] ②Synthesis of A3334

[0192]

[0193] 5'-Methoxy-[2,3'-biindolineylidene]-2',3-dione (6...

preparation Embodiment 2

[0194] Preparation Example 2. Synthesis of 5,6-dichloroindirubin-3'-methoxime (A3051)

[0195] ①Synthesis of intermediate product 5',6'-dichloro-[2,3'-biindolineylidene]-2',3-dione

[0196]

[0197] 5,6-Dichloroisatin (500 mg, 2.32 mmol) was added to a 250 ml round bottom flask and dissolved in methanol (MeOH) (92.80 ml), followed by addition of indole acetate (405.48 mg, 2.315 mmol) and Sodium carbonate (Na 2 CO 3 ) (637.83mg, 6.02mmol), and the mixture was stirred at 65°C for 12 hours. The reaction was quenched by TLC (Rf = 0.4, ethyl acetate / hexane = 1 / 2 (vol / vol)), and the product was cooled on ice until massive crystals formed. After crystals formed, the solvent was removed by filtration. The filtrate was discarded, and the product was washed several times with solvent (ethanol / water=1 / 1 (vol / vol)). The product was filtered, dried in a vacuum pump and used in the next step without further purification.

[0198] ② Synthesis of A3051

[0199]

[0200] Charge ...

preparation Embodiment 3 and 4

[0201] Preparation Examples 3 and 4. Preparation of Indirubin Derivatives, Formula 3 (A3486) and Formula 4 (A3538).

[0202] By the same method, 5,6-dichloroindirubin-3'-methoxime or 5-methoxyindirubin-3'-oxime (dissolved in dimethyl sulfide (DMSO) and used in the experiment ) to synthesize 5,6-dichloroindirubin-3'-oxime propioxime of formula 3 and 6-chloroindirubin-3'-benzyl oxime of formula 4.

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Abstract

The present invention relates to a composition for preventing hair loss or promoting hair growth, the composition comprising: an indirubin derivative; and at least one selected from the group consisting of an Evodia daniellii extract, a Persicaria hydropiper extract, a Hovenia dulcis extract, methyl vanilate, hesperidin, and quercitrin. Furthermore, the at least one selected from the group consisting of an Evodia daniellii extract, a Persicaria hydropiper extract, a Hovenia dulcis extract, methyl vanilate, hesperidin, and quercitrin of the present invention is a natural substance-derived composition and has little toxicity to cells, and the indirubin derivative is a stable compound that has been found to have little toxicity to the human body, so that, unlike a conventional steroid drug, the use thereof as a mixture has an advantage of not showing side effects on the human body.

Description

technical field [0001] The present invention relates to a composition for preventing hair loss or promoting hair growth, which comprises indirubin derivatives and plant extracts or small molecule compounds. Background technique [0002] There are approximately 100,000 to 150,000 hairs in the human body, which form in follicles. Each hair repeats in a different cycle, including anagen, catagen, and telogen. Anagen is the period of hair growth, while catagen is the period when the metabolic process slows down, at which point the anagen phase ends and the hair retains its shape, which slows down hair growth. During catagen, cell division of the hair follicle stops and shrinks rapidly. Anagen phase is when the hair follicles have completely stopped activity and are ready to fall out. Hairs in the telogen phase are pushed out by the hairs growing at the root and fall out on their own, easily removed by physical actions such as combing or washing the hair. These cycles repeat o...

Claims

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Application Information

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IPC IPC(8): A61K8/9789A61K8/49A23L33/105A61Q7/00
CPCA23L33/105A61K8/49A61K8/9789A61Q7/00A61K8/00A61K8/37A61K8/602A61K36/70A61K36/72A61K36/754A61K31/404A61K31/525A61K31/4415A61K2300/00A61K8/492A23V2002/00A23V2200/318A61P17/14A61K9/107A61K31/192A61K31/353A61K31/4045A61K31/7048A61K47/34A61K47/40A61K47/44
Inventor 崔康烈沈智用柳永灿朴智延
Owner CK BIOTECH CO LTD
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