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Medical real silk braided suture line and preparation method thereof

A suture and silk technology, applied in the field of medical sutures, can solve the problems of no bacteriostatic effect and increase surgical site infection, and achieve the effects of reducing infection, excellent long-acting antibacterial, good mechanical properties and degradation performance.

Active Publication Date: 2020-04-28
深圳市迈捷生命科学有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, as a non-absorbable suture, silk suture itself has no antibacterial effect on bacteria and viruses, and the gaps in the weaving structure and the single-fiber gaps inside the silk thread provide hiding places for bacteria, which increase the probability of surgical site infection

Method used

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  • Medical real silk braided suture line and preparation method thereof
  • Medical real silk braided suture line and preparation method thereof
  • Medical real silk braided suture line and preparation method thereof

Examples

Experimental program
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preparation example Construction

[0039] Preparation of p-nitrophenyl adipate: Add 110g of p-nitrophenol, 71.88g of triethylamine and 450mL of acetone into the reaction device in turn, stir and mix at room temperature; Add a mixed solution of 60.405g of adipoyl chloride and 150mL of acetone into the dropping funnel, drop it within 1 hour, and fully react for 4 hours; The water contained in the product can obtain p-nitrophenyl adipate.

[0040] Preparation of lysine dibutylene glycol ester: Weigh 85.12g of L-lysine hydrochloride and 20g of 1,4-butanediol and mix them in the reaction device, add 3g of p-toluenesulfonic acid monohydrate and 25mL of toluene, stirred and reacted at 125°C for 2 hours; after the complete reaction, pour out the toluene, continue to add 500mL of isopropanol, and stir at 70°C until dissolved; after the reaction product is completely dissolved, react to form a mixed solution Store at -19°C for 12 hours at low temperature, dry in vacuum at 55°C to constant weight, and collect lysine dibu...

Embodiment 1

[0047] The preparation method of the medical silk braided suture includes first loading lysine polyester hydrogel on the silk braided suture, and secondly preparing an antibacterial coating on the silk braided suture loaded with lysine polyester hydrogel.

[0048] The process of loading lysine polyester hydrogel on a silk braided suture involves the following steps:

[0049] (1) 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride (EDC) was dissolved in MES buffer solution with pH=5.5 and concentration 0.05mol / L to obtain 1 -(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride (EDC) concentration is 0.1g / mL solution;

[0050] (2) In an ice bath, immerse 3 g of silk braided suture in 40 mL of 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride (EDC) at a concentration of 0.1 g / mL of the solution was stirred and activated for 24 hours as the mixed solution Ⅰ;

[0051] (3) Weigh the lysine polyester ammonia hydrogel and disperse it in water to make a hydrog...

Embodiment 2

[0056] The preparation method of the medical silk braided suture includes first loading lysine polyester hydrogel on the silk braided suture, and secondly preparing an antibacterial coating on the silk braided suture loaded with lysine polyester hydrogel.

[0057] The process of loading lysine polyester hydrogel on a silk braided suture involves the following steps:

[0058] (1) 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride (EDC) was dissolved in MES buffer solution with pH=5.5 and concentration 0.05mol / L to obtain 1 -(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride (EDC) concentration is 0.1g / mL solution;

[0059] (2) In an ice bath, immerse 3 g of silk braided suture in 40 mL of 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride (EDC) at a concentration of 0.1 g / mL of the solution was stirred and activated for 24 hours as the mixed solution Ⅰ;

[0060] (3) Weigh the lysine polyester ammonia hydrogel and disperse it in water to make a hydrog...

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Abstract

The invention discloses a medical real silk braided suture line and a preparation method thereof. Firstly, lysine polyester hydrogel is loaded on a real silk braided suture line, and secondly, an antibacterial coating is prepared on the real silk braided suture line loaded with the lysine polyester hydrogel. The medical silk braided suture line has good mechanical property and degradation property, has antibacterial property, achieves stable and lasting antibacterial property, can effectively promote wound healing, and reduces infection of an operation part.

Description

technical field [0001] The invention relates to the technical field of medical sutures, in particular to medical silk braided sutures and a preparation method thereof. Background technique [0002] As a natural protein fiber containing 18 kinds of amino acids, silk can produce many amino acids needed by the human body under the decomposition of enzymes and microorganisms after being sewn into the human body, which is absorbed by the human body. It is not only harmless to the human body, but also provides useful nourishment. Compared with medical sutures made of chemical fiber materials of the same thread size, silk sutures are also excellent in softness, knotting and bending; at the same time, silk sutures have good hygroscopicity, and can rapidly expand when soaked in blood, full of blood. The eye of the needle can reduce the leakage of blood from the needle hole, and the operation quality is good; the strength of silk suture is also better than that of general natural mat...

Claims

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Application Information

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IPC IPC(8): A61L17/10A61L17/14A61L17/00D06M15/507D06M13/152
CPCA61L17/105A61L17/145A61L17/005D06M15/507D06M13/152D06M16/00A61L2300/404A61L2420/02A61L2420/08A61L2300/412A61L2300/602A61L2300/608D06M2101/10C08L67/00
Inventor 刘科林
Owner 深圳市迈捷生命科学有限公司
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